Lub neuropeptide Y (NPY) taw qhia txoj hauv kev ua lub luag haujlwm tseem ceeb hauv ntau yam txheej txheem physiological thiab pathological; nws cov receptors yog cov hom phiaj kho mob tseem ceeb, thiab NPY nws tus kheej ua lub peev xwm biomarker rau ntau yam kab mob.
Obesity thiab Metabolic Disease
NPY-Y1R/Y5R kev taw qhia txoj hauv kev yog lub luag haujlwm tseem ceeb uas ua rau kev noj qab haus huv thiab qhov hnyav nce, ua rau nws lub hom phiaj tseem ceeb rau kev txhim kho tshuaj tiv thaiv - rog rog. NPY ua raws li kev noj qab haus huv- txhawb nqa. Ib txoj kev tshawb fawb 2024 luam tawm nyob rau hauv * Xwm * qhia tias peripheral NPY, tsim los ntawm cov hlab ntsha sympathetic, exerts los tiv thaiv - rog los ntawm kev tuav cov ntaub sormogenic adipose yam tsis tau hloov cov khoom noj.
Neuropsychiatric Disorders
Cov tib neeg uas muaj lub hlwb qis dua ntawm NPY yog qhov ua rau muaj kev xav tsis zoo thiab kev nyuaj siab. NPY muaj peev xwm tiv thaiv kev ntxhov siab thiab kev nyuaj siab, thiab nws cov qib muaj feem cuam tshuam nrog kev ntxhov siab thiab tom qab-kev puas siab puas ntsws (PTSD). Ib txoj kev tshawb fawb 2024 hauv * Kev Sib Txuas Lus Xwm Txheej * ntxiv qhov tseem ceeb ntawm NPY neurons nyob rau hauv dorsal raphe nucleus thiab ventrolateral periaqueductal grey ntawm lub paj hlwb hauv kev tawm tsam kev ntxhov siab- ua rau tsis qab los noj mov thiab ntxhov siab. Dysregulation ntawm NPY signaling kuj txuas rau kev quav tshuaj nicotine.
Cov Kab Mob Neurodegenerative
Hauv cov qauv kab mob ntawm Alzheimer's, Parkinson's, thiab Huntington's kab mob, NPY nthuav tawm cov teebmeem neuroprotective, txawm hais tias kev hloov pauv hauv nws qib yog kab mob- tshwj xeeb. Piv txwv li, hippocampal NPY qib tau txo qis hauv Alzheimer's cov neeg mob, thaum striatal NPY qib tau nce siab hauv Parkinson cov neeg mob. NPY ua haujlwm raws li ob qho tib si biomarker thiab lub hom phiaj kho mob rau cov mob neurodegenerative no.
