Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov muag khoom ntawm cas 627079-23-6 (cys47)-hiv-1 tat protein (47-57) hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 627079-23-6 (cys47)-hiv-1 tat protein (47-57) los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Kev piav qhia | (Cys47)-HIV-1 tat Protein (47-57) (CAS: 627079-23-6) yog ib qho 11-amino-acid cell-penetrating peptide nrog se Cys-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg (CGRKKRRQRRR), a TATder tau los ntawm{2 (Tyr) nrog cysteine (Cys) ntawm N-qhov kawg ntawm cov kab mob HIV classic-1 Tat protein transduction domain (residues 47-57, YGRKKRRQRRR). N-terminal cysteine muab ib pawg thiol dawb (-SH), uas tuaj yeem siv rau kev sib txuas nrog thiol-reactive reagents xws li maleimides, iodoacetamides, thiab pyridyl disulfides, txuas TAT peptide rau lwm cov proteins, nanoparticles, nucleus, lipoproteins. Muab piv rau classic TAT(47-57) (YGRKKRRQRRR), N-terminal Tyr → Cys hloov pauv tshem tawm cov fluorescence ntawm tyrosine tab sis qhia txog cov tshuaj thiol ntau dua, ua kom yooj yim ntawm qhov chaw- tshwj xeeb conjugation. Cov peptide no yog nplua nuj nyob rau hauv arginine (6 Arg) thiab lysine (2 Lys), tag nrho 8 cov amino acid residues, nqa cov nqi zoo nyob rau hauv physiological pH. Lub xovtooj ntawm -kev nkag mus ntawm (Cys47)-TAT(47-57) suav nrog: (1) electrostatic binding rau heparan sulfate proteoglycans (HSPG) ntawm lub cell membrane nto - cov guanidinium pawg ntawm arginine residues tsim cov khoom siv hluav taws xob sib txuas nrog PG HS sulfate; (2) clathrin-dependent thiab caveolin-dependent endocytosis; (3) macropinocytosis; (4) endosomal khiav tawm - lub zog zoo thiab cov nyhuv proton sponge pab rupture endosomal membranes; (5) direct transmembrane translocation nyob rau hauv tej yam kev mob. Cov yam ntxwv tseem ceeb thiab kev siv ntawm no peptide: (1) membrane translocation function - muaj peev xwm ntawm cell membrane nkag mus rau hauv kev ua si, mediating intracellular xa khoom ntawm ntau yam cargoes; (2) N-terminal cysteine conjugation - Cys residue muab qhov chaw thiol-reactive rau qhov chaw yooj yim-specific conjugation; (3) Kev hloov kho cov tshuaj sib nqus - tuaj yeem siv los ua cov khoom sib nqus ntawm cov tshuaj sib nqus, ua kom yooj yim rau lawv nkag mus rau hauv cov phiaj hlwb; (4) gene xa - tsim complexes nrog DNA / siRNA / mRNA los txhawb cov noob hloov; (5) kev xa cov protein thiab peptide - kev sib haum xeeb hauv kev xa khoom ntawm cov protein thiab peptides ua haujlwm; (6) nanoparticle functionalization - hloov qhov chaw ntawm liposomes, polymer micelles, thiab nanoparticles los txhim kho cellular uptake. N-terminal cysteine yuav tsum tau saib xyuas kom tsis txhob oxidation thiab dimer tsim thaum lub sij hawm cia thiab siv; cia nyob rau hauv inert gas tiv thaiv thiab siv cov freshly npaj daws yog pom zoo. |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| (Cys47)-HIV-1 tat Protein (47-57) | Cysteine - hloov TAT peptide (47-57); Cys-TAT cell-penetrating peptide | Cell-kev nkag mus rau peptide, thiol site-kev sib txuas tshwj xeeb, kev xa cov protein / tshuaj, hloov pauv cov cab kuj | Core penetrating segment of HIV-1 TAT protein (residues 47–57) nrog cysteine hloov pauv ntawm txoj hauj lwm 47; khaws cov cell nkag mus tau zoo thiab kev ua haujlwm hauv thaj chaw nuclear, dawb thiol ua rau thaj chaw tshwj xeeb sib txuas ntawm cov tshuaj, cov protein thiab nanocarriers ntawm disulfide bonds | C₆₉H₁₂₁N₂₇O₁₅S | 1559.91 | ~1561.2 | Acetate | 11 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-TAT-C47 | Dawb hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb, nyob rau hauv inert gas. Aliquot rau cia. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; tiv thaiv cov pa oxygen thaum thauj khoom. | ruaj khov rau 7 hnub ntawm 4 degree. Soluble hauv dej, dilute acetic acid thiab acidic buffers. Dawb thiol ntawm cysteine rhiab heev rau oxygen thiab hlau ions; Nws yooj yim rau oxidation thiab disulfide tsim. Tsis txhob sib xyaw nrog oxidants thiab hnyav hlau. | ruaj khov rau 2 xyoos ntawm -20 degree, qhuav, tiv thaiv los ntawm lub teeb thiab nyob rau hauv inert roj. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-TAT-C47 | Cysteine - hloov kho TAT CPP ua ke thiol conjugation thiab kev xa tawm hauv lub cev tau zoo | Cys47-hloov TAT peptide khaws cov cell nkag mus tau zoo thiab kev ua haujlwm nuclear hauv zos ntawm cov neeg TAT, kev sib kho kom sai ntawm cov protein, nucleic acids thiab nanoparticles rau hauv hlwb thiab nuclei. Lub cysteine ntawm txoj hauj lwm 47 muab qhov chaw pub dawb thiol reactive site rau qhov chaw tshwj xeeb conjugation ntawm cov tshuaj, proteins thiab nanocarriers ntawm disulfide bonds los yog maleimide ntxiv, ua hauj lwm hloov kho cov cuab yeej rau lub hom phiaj xa khoom. | Protein drug conjugation, targeted drug development, cell- nkag mus rau tus me nyuam, kev hloov kho nanocarrier, qhov chaw- kev hloov kho tshuaj tshwj xeeb | Phospholipid bilayer; cysteine thiol disulfide conjugation; TAT-kev thauj mus los nruab nrab |
Cim npe nrov: cas 627079-23-6 (cys47)-hiv-1 tat protein (47-57), China cas 627079-23-6 (cys47)-hiv-1 tat protein (47-57) manufacturers, lwm tus, Hoobkas
