Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas119719-11-8; ilatreotide hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas119719-11-8; ilatreotide los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS : 119719-11-8: Ilatreotide |
| Kev piav qhia | Ilatreotide yog siab -affinity agonist tsom rau somatostatin SSTR2/SSTR5 dual receptors. Cyclic peptide qaum qaum thiab D-amino acids txhim kho metabolic stability, nrog superior subtype selectivity rau haiv neeg somatostatin. Siv rau hauv kev tshawb fawb mechanisms ntawm cov qog neuroendocrine, pituitary adenomas thiab cov tshuaj hormone secretion disorders. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Molecular Formula | C₅₃H₆₈N₁₀O₁₀S₂ (dawb puag) |
| Molecular Luj (Da) | 1069.30 |
| Hloov kho Terminal | C-terminal amidation |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Tag Nrho Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Nruab nrab MW (Da) | N-Terminal Hloov kho | C-Terminal Hloov kho | Qhov ntev (aa) |
| Ilatreotide | Ilatreotide; BIM-23056; CAS 119719-11-8; SSTR2/5 dual agonist | SSTR2 / SSTR5 dual receptor agonist, Neuroendocrine qog kev tshawb fawb, Hormone secretion inhibition, Cyclic peptide stability, Receptor subtype selectivity, Somatostatin analog | D-Phenylalanine-cysteine-tyrosine-D-tryptophan-lysine-valine-cysteine-threoninamide (cyclized ntawm Cys2-Cys7 disulfide choj) | C₅₃H₆₈N₁₀O₁₀S₂ (dawb puag) | 1068.45 | 1069.3 | Dawb amine, D-amino acid configuration | Amidation | 8 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv -Lub Sijhawm Cia Cov Cai | Kua Stability | Khoom hmoov ruaj khov |
| PEB-ILA001 | hmoov dawb | Khaws ntawm -20 degree, nruj me ntsis tiv thaiv los ntawm lub teeb, kaw thiab qhuav, aliquoted. nruj me ntsis txwv tsis pub muaj zog txo cov neeg ua haujlwm | Khoom hmoov ruaj khov rau 2 xyoos ntawm 2-8℃kaw thiab qhuav; me me ntawm DMSO tuaj yeem muab ntxiv rau cov kev daws teeb meem rau solubilization | ruaj khov rau 72 h ntawm 4 degree; ruaj khov rau 1 lub hlis ntawm -20℃hauv aliquots. ** Me ntsis soluble hauv dej, me me ntawm DMSO lossis dilute acetic acid xav tau rau solubilization **. Disulfide choj yog rhiab heev rau txo cov neeg ua hauj lwm thiab nquag cleavage. Aromatic residues yog lub teeb-sensitive thiab yooj yim degraded | ruaj khov rau 3 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-ILA001 | Siab -affinity SSTR2/SSTR5 dual receptor agonist nrog synergistic hormone secretion thiab qog proliferation inhibition | Ilatreotide yog qhov zoo tshaj plaws somatostatin analog. D-amino acid hloov pauv thiab disulfide cyclization tseem ceeb txhim kho metabolic stability thiab receptor affinity, khi nrog siab tshwj xeeb rau ob qho tib si SSTR2 thiab SSTR5 subtypes, nrog rau receptor binding profile ze rau haiv neeg somatostatin. Receptor activation inhibits adenylate cyclase, txo intracellular cAMP theem, muaj zog inhibits secretion ntawm ntau yam tshuaj hormones xws li kev loj hlob hormone, insulin, glucagon thiab gastrin, thiab ib txhij inhibits qog cell proliferation, induces apoptosis thiab constricts qog cov hlab ntsha. Ua kom muaj zog ua haujlwm tawm tsam ntau yam qog nqaij hlav neuroendocrine thiab pituitary adenomas, nws ua haujlwm ua cov cuab yeej tseem ceeb rau kev tshawb fawb txog tshuaj hormone secretion disorder, neuroendocrine qog mechanism kev tshawb fawb thiab subtype - xaiv somatostatin tshuaj txhim kho. | Neuroendocrine qog kev tshawb fawb, Kev tshawb fawb Pituitary adenoma, Kev tshawb fawb txog tshuaj hormone secretion regulation, Somatostatin pathway research, Subtype -selective drug development, qog proliferation inhibition research | Somatostatin Receptor 2 (SSTR2); Somatostatin Receptor 5 (SSTR5); cAMP/PKA teeb liab txoj kev; Hormone secretion thiab qog proliferation txoj cai txoj kev |
Cim npe nrov: CAS 119719-11-8; ilatreotide, Tuam Tshoj cas119719-11-8; ilatreotide manufacturers, lwm tus, Hoobkas
