Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas: 152074-97-0: dirucotide hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas: 152074-97-0: dirucotide los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 152074-97-0: Dirucotide |
| Kev piav qhia | Dirucotide (MBP 8298) yog haiv neeg 17-mer peptide fragment ntawm tib neeg myelin yooj yim protein, sib xws rau MBP amino acid sequence 83-99. Nws induces tiv thaiv kab mob nyob rau hauv myelin-specific autoreactive T hlwb, txo autoimmune nres ntawm central paj hlwb myelin, thiab ncua kev loj hlob ntawm ntau yam sclerosis. Siv rau hauv cov kab mob autoimmune demyelinating, tiv thaiv kev tiv thaiv kab mob thiab kev tshawb fawb tshuaj tiv thaiv peptide. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Hom qauv | Ib haiv neeg myelin protein- muab tau cov kab 17-mer peptide, tsis muaj tshuaj hloov kho |
| Molecular Luj (Da) | ~1960 |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Tag Nrho Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Nruab nrab MW (Da) | N-Terminal Hloov kho | C-Terminal Hloov kho | Ntev (aa) |
| Dirucotide | Dirucotide; PAB 8298; Myelin yooj yim protein peptide; CAS Nr .: 152074-97-0 | Kev tiv thaiv kab mob tiv thaiv kab mob, Kev tshawb fawb ntau yam sclerosis, kev tiv thaiv Myelin, kab mob autoimmune, T cell epitope peptide, tshuaj tiv thaiv Peptide | Aspartic acid -glutamic acid-asparagine-proline-valine-valine-histidine-phenylalanine-phenylalanine{{8} }lysine-asparagine-isoleucine-valine-threonine-proline-arginine-threonine | Loj polypeptide, tsis muaj meej me me -molecule mis; raws li qhov tseeb batch MS | - | Xyoo 1960 (theoretical) | Dawb amine, tsis muaj kev hloov kho | Dawb carboxyl, tsis muaj kev hloov kho | 17 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv luv -Lub Sijhawm Cia Cia | Kua Stability | Khoom hmoov ruaj khov |
| PEB-DRC001 | hmoov dawb | Khaws ntawm -20 degree, kaw, qhuav & tiv thaiv los ntawm lub teeb, aliquoted; zam rov qab khov-thaw cycles | Khoom hmoov ruaj khov rau 1 xyoo ntawm 2-8℃kaw & qhuav; npaj cov tshuaj aqueous tshiab ua ntej siv | ruaj khov rau 48 h ntawm 4 degree; ruaj khov rau 2 lub lis piam ntawm -20℃hauv aliquots. ** Cov dej zoo solubility, dawb do soluble hauv dej thiab physiological tsis **. Unmodified haiv neeg ntev peptide yooj yim degraded los ntawm peptidases nrog kev ua kom sai sai ntawm chav tsev kub. Histidine thiab tyrosine nquag rau photooxidation | ruaj khov rau 2 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov Cheeb Tsam Tshawb Fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-DRC001 | Native myelin cov protein ntau 17-mer peptide uas ua rau autoimmune kam rau ua thiab qeeb demyelination kev loj hlob hauv ntau yam sclerosis | Dirucotide yog ib haiv neeg T cell epitope peptide muab los ntawm tib neeg myelin yooj yim protein (MBP), sib haum mus rau lub immunodominant epitope ntawm txoj hauj lwm 83-99 ntawm MBP molecule. Tom qab tau txais los ntawm antigen- nthuav tawm cov hlwb, nws tau nthuav tawm rau autoreactive CD4+ T hlwb ntawm MHC chav kawm II molecules, inducing T cell anergy, apoptosis los yog hloov mus rau kev tswj T cells, tsim kom muaj kev tiv thaiv kab mob rau myelin antigens, yog li txo T cell-mediated my central cerebral kev puas tsuaj rau cov hlab ntsha thiab cov hlab ntsha. kev loj hlob ntawm ntau yam sclerosis. Cov peptide no yog ib txwm muaj cov kab mob endogenous protein nrog me me immunogenicity thiab tsis muaj kev phiv tshuaj lom. Nws ua haujlwm ua cov cuab yeej tseem ceeb rau kev tshawb fawb ntau yam sclerosis immunotherapy, autoimmune tolerance mechanism tsom xam, myelin antigen epitope txheeb xyuas, thiab tshuaj tiv thaiv peptide SAR optimization. | Kev tshawb fawb ntau yam sclerosis, Kev tshawb nrhiav kab mob autoimmune, Kev tiv thaiv kab mob tiv thaiv kab mob, Demyelinating kab mob kev tshawb fawb, T cell epitope tshawb fawb, tshuaj tiv thaiv Peptide | MHC class II molecule -peptide complex; Myelin- tshwj xeeb autoreactive T cells; Central immune tolerance regulatory txoj kev |
Cim npe nrov: CAS: 152074-97-0: dirucotide, Tuam Tshoj cas: 152074-97-0: dirucotide manufacturers, lwm tus neeg, Hoobkas
