Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas: 2233558-98-8: lefleuganan hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas: 2233558-98-8: lefleuganan los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 2233558-98-8: Lefleuganan |
| Kev piav qhia | Lefleuganan yog ib tug tshiab - tiam tshiab xaiv S1P₁ receptor agonist. Nws tshwj xeeb khi rau S1P₁ receptors ntawm lymphocyte nto, induces lymphocyte homing rau peripheral lymph nodes, txo tus naj npawb ntawm circulating pathogenic autoreactive lymphocytes, thiab alleviates autoimmune inflammatory puas nyob rau hauv nruab nrab thiab peripheral ntaub so ntswg. Siv rau hauv kev tshawb fawb mechanism ntawm autoimmune kab mob xws li ntau yam sclerosis thiab inflammatory plob tsis so tswj kab mob, thiab immunomodulator tshuaj txhim kho. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Theoretical molecular formula | C₂₇H₃₀F₃N₃O₄ |
| Theoretical molecular hnyav (Da | 517.55 |
| Hom qauv | Tsis yog -peptidic me me molecule S1P receptor ligand |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Hom qauv | Lub Hom Phiaj Xaiv |
| Lefleuganan | Lefleuganan; S1P₁ receptor agonist; CAS Nr .: 2233558-98-8 | High S1P₁ selectivity, Lymphocyte homing, Autoimmunity suppression, Ntau yam sclerosis kawm, Immunomodulator, Tsis tshua muaj mob plawv | Aromatic cycloalkyl niam txiv nucleus nrog trifluoromethyl hloov thiab carboxylic acid polar kawg | C₂₇H₃₀F₃N₃O₄ (theoretical) | 517.22 | 517.55 | Tsis yog -peptidic me me molecule derivative | Siab S1P₁ receptor selectivity |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv -Lub Sijhawm Cia Cov Cai | Kua Stability | Khoom hmoov ruaj khov |
| SML-LEF001 | hmoov dawb | Khaws ntawm -20 degree, kaw, qhuav & tiv thaiv los ntawm lub teeb, aliquoted; zam qhov kub thiab av noo | Khoom hmoov ruaj khov rau 2 xyoos ntawm 2-8℃kaw & qhuav; Cov kev daws teeb meem yuav tsum tau npaj hauv DMSO | ruaj khov rau 1 lub hlis ntawm 4℃hauv maub & anhydrous tej yam kev mob; ruaj khov rau 3 lub hlis ntawm -20℃hauv aliquots. ** Tsis tshua muaj dej solubility, yuav luag insoluble hauv dej; DMSO lossis anhydrous ethanol yuav tsum tau **. High lipophilicity, nquag adsorb rau cov khoom siv yas. Sensitive rau lub teeb thiab kub | ruaj khov rau ntau tshaj 3 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| SML-LEF001 | Kev xaiv ntau S1P₁ receptor agonist uas induces lymphocyte homing kom alleviate autoimmune o nrog tsawg mob plawv. | Lefleuganan yog ib hom subtypes - optimized S1P receptor agonist nrog siab affinity thiab selectivity rau S1P₁ receptors, thiab tsis tshua muaj affinity rau cardiovascular -txog subtypes xws li S1P₃, nrog txo cov kev mob tshwm sim xws li bradycardia. Nws khi rau S1P₁ receptors ntawm lymphocyte nto, induces receptor endocytosis thiab desensitization, blocks lymphocyte migration raws S1P concentration gradient mus rau periphery, txhawb lymphocyte homing thiab tuav nyob rau hauv lymph nodes, txo tus naj npawb ntawm pathogenic autoreactive T thiab B hlwb nyob rau hauv peripheral inflammatory dab nyob rau hauv lub peripheral cov ntshav. cov ntaub so ntswg. Piv nrog rau thawj- tiam tsis yog{10}} xaiv S1P agonists, nws muaj ntau dua subtype selectivity, zoo dua plawv kev nyab xeeb thiab ruaj khov nyob rau hauv vivo metabolism. Cov molecule no ua haujlwm raws li cov cuab yeej tshawb fawb txog cov kab mob autoimmune xws li ntau yam sclerosis, neuromyelitis optica thiab kab mob plab hnyuv, thiab tseem yog ib qho tseem ceeb hauv kev tsim cov tshuaj tshiab - tiam ntawm qhov ncauj immunomodulator. | Kev tshawb fawb ntau yam sclerosis, Kev tshawb nrhiav kab mob autoimmune, Lymphocyte migration research, S1P pathway study, Immunomodulator development, Inflammatory bowel research | Sphingosine-1-Phosphate Receptor 1 (S1P₁); Lymphocyte homing tswj txoj kev; autoimmune inflammatory inhibitory txoj kev |
Cim npe nrov: cas: 2233558-98-8: lefleuganan, Tuam Tshoj cas: 2233558-98-8: lefleuganan manufacturers, lwm tus neeg, Hoobkas
