Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 63775-95-1 cyclosporin b hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 63775-95-1 cyclosporin b los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 63775-95-1: Cyclosporin B |
| Kev piav qhia | Cyclosporin B yog cov kab mob fungal - muab tau los ntawm hydrophobic cyclic undecapeptide, calcineurin inhibitor class immunosuppressant. Nws tsim ib txoj hauv kev los ntawm kev khi rau cyclophilin, thaiv T cell activation txoj hauv kev, thiab siv rau hauv kev hloov pauv hauv nruab nrog cev, kab mob autoimmune thiab kev tshawb fawb ntawm immunopharmacology mechanism. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Cov mis mos molecular | C₆₁H₁₀₉N₁₁O₁₂ |
| Molecular Luj (Da) | 1188.58 |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Puv Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | N-Terminal Hloov kho | C-Terminal Hloov kho | Qhov ntev (aa) |
| Cyclosporin B | Cyclosporin B; CyB; CAS 63775-95-1; Calcineurin inhibitor | Calcineurin inhibition, Immunosuppression, T cell activation blockade, Transplant rejection research, Autoimmune disease research, Fungal - muab tau los ntawm cyclopeptide | Cyclic qaum: (4R)-4-[(E)-2-butenyl]-4,N-dimethyl-L-threonine-L{-alanine-sarcosine-N-methyl-L-leucine-L-valine{{21} }N-methyl-L-leucine-L-alanine-D-alanine-N-met hyl-L-leucine-N-methyl-L-leucine-N-methyl-L-valine (lub taub hau-rau-tail amide cyclization, 7 N-methylated amino acids) | C₆₁H₁₀₉N₁₁O₁₂ | 1187.82 | 1188.58 | Lub taub hau -rau-tail cyclized, tsis muaj amine dawb | Lub taub hau - mus rau -tail cyclized, tsis muaj carboxyl dawb | 11 (nrog rau cov amino acids tsis zoo) |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv -Lub Sijhawm Cia Cov Cai | Kua Stability | Khoom hmoov ruaj khov |
| PEB-CYB001 | hmoov dawb | Khaws ntawm -20 degree, nruj me ntsis tiv thaiv los ntawm lub teeb, kaw thiab qhuav, khaws cia hauv nitrogen hauv aliquots; tsis txhob rov qab khov-thaw cycles, oxidation thiab kub kub | Khoom hmoov ruaj khov rau 2 xyoos kaw thiab qhuav ntawm 2-8 degree; DMSO cov kev daws teeb meem ruaj khov rau 1 lub hlis ntawm -20℃hauv qhov tsaus ntuj | ruaj khov rau 72 h ntawm 4 degree; ** Tsis tshua muaj dej solubility, ze li insoluble hauv dej **. Soluble hauv cov kuab tshuaj organic xws li DMSO, methanol thiab ethanol. Unsaturated ob daim ntawv cog lus nws yooj yim rau oxidative degradation, tsis txhob ntev huab cua raug thiab lub teeb muaj zog | Ruaj khov rau 3 xyoos ntawm -20℃nyob rau hauv qhuav, tsaus thiab nitrogen cua |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-CYB001 | Fungal- muab tau los ntawm cyclic undecapeptide immunosuppressant uas khi cyclophilin thiab inhibits calcineurin txoj hauv kev, thaiv T cell ua kom, siv rau hauv kev hloov pauv kev tiv thaiv kab mob thiab kev tshawb nrhiav kab mob autoimmune | Cyclosporin B yog hydrophobic cyclic undecapeptide cais los ntawm fungal metabolites, teej tug mus rau calcineurin inhibitor tsev neeg nrog ib tug mechanism homologous rau cyclosporin A. Nws khi nrog siab affinity rau intracellular cyclophilin, tsim ib cov tshuaj -cyclophilin complex uas tshwj xeeb tshaj yog binds ntawm sequins. calcineurin, thaiv kev dephosphorylation thiab nuclear translocation ntawm nuclear activated T hlwb (NF-AT). Qhov no inhibits transcription thiab secretion ntawm pro-inflammatory cytokines xws li IL-2 thiab IFN- , thiab ntes T cell ua kom thiab proliferation. Nrog rau kev ua haujlwm tsis muaj zog tiv thaiv kab mob ntau dua li cyclosporin A, nws yog ib qho cuab yeej tseem ceeb rau kev hloov lub cev tiv thaiv kab mob, kab mob autoimmune pathogenesis, calcineurin signaling txoj kev tshawb fawb thiab kev tshuaj ntsuam xyuas tshuaj tiv thaiv kab mob. | Kev tshawb fawb txog kev hloov tshuaj tiv thaiv kab mob, Kev tshawb fawb txog kev hloov pauv hauv nruab nrog cev, Kev tshawb fawb txog kab mob autoimmune, Calcineurin txoj kev tshawb fawb, T cell activation mechanism kev tshawb fawb, Immunosuppressive tshuaj txhim kho | Cyclophilin; Calcineurin/NF-AT signaling pathway; T cell activation thiab cytokine secretion txoj kev |
Cim npe nrov: CAS 63775-95-1 cyclosporin b, Tuam Tshoj cas 63775-95-1 cyclosporin b manufacturers, lwm tus, Hoobkas
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