Tau Peptide (277-291) CAS 330456-40-1

Khoom Lub Npe Lus Askiv

Product Abbreviation / Alias

Function Tags (comma-sib cais)

Amino Acid Tag Nrho Lub Npe Sequence

Molecular Formula

Qhov hnyav Molecular (Da)

Qhov Nruab Nrab Molecular Luj (Da)

Terminal Hloov kho - N-terminus

Terminal Hloov kho - C-terminus

Qhov ntev (aa)

Tau Peptide (277-291)

#Tau(277-291) #Microtubule-binding tau fragment; #Neurofibrillary tangle peptide; #Tau phosphorylation research

Tau protein phosphorylation, microtubule sib dhos tswj, neurofibrillary tangles, Alzheimer's kab mob, neurodegeneration, kinase substrate

Serine-Serine-Serine-Proline-Serine-Serine-Serine-Serine-Proline-Serine-Serine-Serine-Proline-Serine-Serine

C₆₉H₁₀₄N₂₆O₃₃

1816.741

1817.71

Tsis hloov

Dawb carboxyl pawg

15

Khoom Code

Qhov tshwm sim

Pom zoo Dissolution Protocol (los ntawm hnyav)

Solubility Reference

Tsis pom zoo Solvents

Ntev - Lub Sij Hawm Cia Cov Cai

Luv luv -Lub Sijhawm Cia Cia

Kua Stability

Khoom hmoov ruaj khov

Muaj feem xyuam pH Range

PEP-Tau01

Dawb lyophilized hmoov

Dilute acetic acid, dej ultrapure; Tsawg solubility nyob rau hauv nruab nrab cov dej ntshiab, ntxiv glacial acetic acid los txhim kho solubility

Ntau dua lossis sib npaug li 10mg / mL hauv 0.1% aqueous acetic acid

Tsis muaj dej ntshiab, alkane organic solvents

-20 degree, kaw kom deb ntawm lub teeb, aliquoted, tsis txhob rov khov-thaww

2-8 degree, siv hauv 1 lub hlis; npaj tshiab ua ntej kev sim

Ruaj khov rau 24 teev ntawm 4 degree

3 xyoos ntawm -20 degree, 2 xyoos ntawm 4 degree

3.0-7.0

Khoom Code

Frontend Short Summary (rau cov npe tshawb nrhiav)

Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg

Cov Cheeb Tsam Tshawb Fawb (comma- cais)

Hom phiaj / Receptor

PEP-Tau01

Tau(277-291) yog ib qho microtubule-binding fragment ntawm tib neeg tau protein nrog ntau qhov chaw serine phosphorylation, siv hauv tau kinase thiab neurofibrillary pathology tshawb fawb

Tau Peptide (277-291) belongs rau cov tub ntxhais rov ua dua ntawm microtubule-sociated tau protein, nplua nuj nyob rau hauv Ser-Pro phosphorylation motifs, ua raws li ntuj substrate rau cov tseem ceeb tau kinases suav nrog GSK-3 thiab CDK5. Nyob rau hauv physiological tej yam kev mob, nws stabilizes neuronal microtubule los ua ke; abnormally hyperphosphorylation abolishes nws microtubule-binding peev thiab ua rau aggregation rau hauv neurofibrillary tangles (NFTs). Nws yog dav siv nyob rau hauv vitro assays: tau kinase kev tshuaj ntsuam xyuas, phosphorylation hloov kho mechanism, pathological kawm ntawm Alzheimer's kab mob & frontotemporal dementia, anti-tau aggregation tshuaj ntsuam xyuas, haum rau neuropathology thiab protein kinase pharmacology tshawb fawb

Cov kab mob neurodegenerative, Alzheimer's kab mob, tau phosphorylation, kinase tshuaj ntsuam, microtubule dynamics, neurofibrillary tangles

GSK-3, CDK5, tubulin, tau oligomers

Khoom Code

Purity Detection Method

Molecular Weight Verification Method

Quality Control Indicators

Impurity Control Standards

PEP-Tau01

Rov qab-theem HPLC

ESI-MS Mass Spectrometry

Purity, dej ntsiab lus, acetate ntsev, hnyav hlau

Ib qho impurity Tsawg dua lossis sib npaug li 2%, tag nrho impurities Tsawg dua lossis sib npaug li 5%

SKU Unique Code

Yam khoom Code

HPLC Purity

Ntim Specification

Lub Sijhawm Ua Haujlwm Ntau Lawm

Customizable

Optional Custom Modifications

Cov ntaub ntawv suav nrog

PEP-Tau01-98-1

PEP-Tau01

Ntau dua lossis sib npaug li 98%

1mg ib

3-7 hnub ua haujlwm

Yog lawm

Acetylation, amidation, fluorescent labeling, biotin labeling

CoA, HPLC chromatogram, MS mass spectrum

PEP-Tau01-98-5

PEP-Tau01

Ntau dua lossis sib npaug li 98%

5mg ib

3-7 hnub ua haujlwm

Yog lawm

Acetylation, amidation, fluorescent labeling, biotin labeling

CoA, HPLC chromatogram, MS mass spectrum

PEP-Tau01-95-1

PEP-Tau01

Ntau dua lossis sib npaug li 95%

1mg ib

3-7 hnub ua haujlwm

Yog lawm

Acetylation, amidation, fluorescent labeling, biotin labeling

CoA, HPLC chromatogram, MS mass spectrum