Shanghai Sunite Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cilofungin cas 79404-91-4 hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau kev lag luam wholesale bulk zoo cilofungin cas 79404-91-4 los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 79404-91-4; LOJ 121019 |
| Ib ntus | |
| Peb tsab ntawv ib ntus | |
| Peptide purity (HPLC, %) | 95%/98% |
| Cov mis mos molecular | C49H71N7O17 |
| Molecular Luj (Da) | 1030.12 |
Product Basic Information Table
|
Khoom Lub Npe Lus Askiv |
Product Abbreviation / Alias |
Function Tags (comma-sib cais) |
Amino Acid Tag Nrho Lub Npe Sequence |
Molecular Formula |
Qhov hnyav Molecular (Da) |
Qhov Nruab Nrab Molecular Luj (Da) |
Terminal Hloov kho - N-terminus |
Terminal Hloov kho - C-terminus |
Qhov ntev (aa) |
|
Cilofungin |
#Cilofungin; CAS 79404-91-4; LY121019; Echinocandin B derivative; p-Octyloxybenzoyl echinocandin B |
Antifungal peptide, Echinocandin class, -glucan synthase inhibitor, Cyclic lipopeptide, Candida inhibitor, Cell phab ntsa synthesis inhibition, Kev tshawb fawb tshuaj tua kab mob |
Cyclic hexapeptide: 4,5-Dihydroxy-L-ornithine-Threonine-3-hydroxy-4-}methyl-L-proline-3,4-dihydroxy-L-homotycleon-hydroxycleon-3. |
C₄₉H₇₁N₇O₁₇ |
1029.49 |
1030.13 |
N²-p-Octyloxybenzoyl (lipidated) |
Cyclized, tsis pub dawb C-terminus |
6 |
Physicochemical Solubility & Cia Parameters
|
Khoom Code |
Qhov tshwm sim |
Pom zoo Dissolution Protocol (los ntawm hnyav) |
Solubility Reference |
Tsis pom zoo Solvents |
Ntev - Lub Sij Hawm Cia Cov Cai |
Luv -Lub Sijhawm Cia Cov Cai |
Kua Stability |
Khoom hmoov ruaj khov |
Muaj feem xyuam pH Range |
|
PEB-CIL001 |
Dawb kom tawm -dawb lyophilized hmoov |
DMSO, Methanol; pab dissolution nrog me me ntawm anhydrous ethanol; tsawg aqueous solubility, npaj DMSO Tshuag tov rau dilution |
Ntau dua lossis sib npaug li 10 mg / mL (DMSO); me ntsis soluble hauv dej |
Cov dej ntshiab (solubility tsawg heev), alkane organic solvents |
-20 degree, kaw thiab lub teeb- pov thawj, aliquot kom tsis txhob rov khov-thaw |
2 ~ 8 degree, siv hauv 1 lub hlis, npaj tshiab ua ntej siv |
ruaj khov rau 48 h ntawm 4℃(hauv DMSO) |
ruaj khov rau 2 xyoos ntawm -20 degree |
4.0~8.0 |
Functional Description
|
Khoom Code |
Frontend Short Summary (rau cov npe tshawb nrhiav) |
Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg |
Cov cheeb tsam tshawb fawb (comma- cais) |
Hom phiaj / Receptor |
|
PEB-CIL001 |
Cilofungin yog cyclic lipopeptide antifungal tus neeg sawv cev muab los ntawm echinocandin B, tshwj xeeb yog inhibits fungal cell phab ntsa -1,3-glucan synthase nrog muaj zog ua haujlwm tiv thaiv Candida albicans thiab Candida tropicalis. |
Cilofungin (LY121019) yog thawj- tiam ib nrab-synthetic echinocandin cyclic lipopeptide, tau los ntawm enzymatic deacylation ntawm echinocandin B ua raws li tshuaj reacylation nrog p-octyloxybenzoic acid. Nws tshwj xeeb yog inhibits fungal cell phab ntsa -1,3-D-glucan synthase (Fks1/Fks2 complex), thaiv -glucan biosynthesis thiab ua rau cell phab ntsa tsis xws luag thiab osmotic lysis. Tso tawm muaj zog hauv vitro tshuaj tiv thaiv kab mob tiv thaiv cov poov xab nrog rau Candida albicans thiab Candida tropicalis, nrog MIC₉₀ Tsawg dua lossis sib npaug li 0.31 ug / mL. Raws li ib tug classic echinocandin cov cuab yeej compound, nws yog dav siv nyob rau hauv fungal cell phab ntsa synthesis mechanism kev tshawb fawb, antifungal tshuaj ntsuam xyuas, Candida kab mob qauv thiab cov qauv-kev sib raug zoo kev tshawb fawb ntawm lipopeptide tshuaj tua kab mob. |
Antifungal pharmacology, Microbiology, Fungal cell phab ntsa synthesis tshawb fawb, Candida kab mob kev tshawb fawb, Lipopeptide tshuaj tua kab mob, Tshuaj ntsuam xyuas & SAR, Kev Tshawb Fawb & Kev tiv thaiv kab mob |
-1,3-Glucan synthase (1,3- -D-glucan synthase, Fks1/Fks2) |
Cov Ntaub Ntawv Tswj Xyuas Zoo
|
Khoom Code |
Purity Detection Method |
Molecular Weight Verification Method |
Kev Tswj Xyuas Qhov Ntsuas |
Impurity Control Standards |
|
PEB-CIL001 |
HPLC High Performance Liquid Chromatography |
ESI-MS Mass Spectrometry |
Purity, dej ntsiab lus, residual hnyav, hnyav hlau |
Ib qho impurity Tsawg dua lossis sib npaug li 2%, Tag nrho cov impurities Tsawg dua lossis sib npaug li 5% |
SKU Specifications & Inventory Table
|
SKU Unique Code |
Yam khoom Code |
HPLC Purity |
Ntim Specification |
Lub Sijhawm Ua Haujlwm Ntau Lawm |
Customizable |
Optional Custom Modifications |
Cov ntaub ntawv suav nrog |
|
PEB-CIL001-98-1 |
PEB-CIL001 |
Ntau dua lossis sib npaug li 98% |
1mg ib |
5-10 hnub ua haujlwm |
Yog lawm |
Isotope labeling, Lipid saw variants, Fluorescent labeling |
CoA, HPLC spectrum, MS huab hwm coj spectrum |
|
PEB-CIL001-98-5 |
PEB-CIL001 |
Ntau dua lossis sib npaug li 98% |
5mg ib |
5-10 hnub ua haujlwm |
Yog lawm |
Isotope labeling, Lipid saw variants, Fluorescent labeling |
CoA, HPLC spectrum, MS huab hwm coj spectrum |
|
PEB-CIL001-95-1 |
PEB-CIL001 |
Ntau dua lossis sib npaug li 95% |
1mg ib |
5-10 hnub ua haujlwm |
Yog lawm |
Isotope labeling, Lipid saw variants, Fluorescent labeling |
CoA, HPLC spectrum, MS huab hwm coj spectrum |
Cim npe nrov: Cilofungin CAS 79404-91-4, Tuam Tshoj cilofungin cas 79404-91-4 manufacturers, lwm tus neeg, Hoobkas
