CP7-FP13-2 CAS Nr .: 3032621-32-9

Khoom Lub Npe Lus Askiv

Product Abbreviation / Alias

Function Tags (comma-sib cais)

Amino Acid Tag Nrho Lub Npe Sequence

Molecular Formula

Qhov hnyav Molecular (Da)

Qhov Nruab Nrab Molecular Luj (Da)

Terminal Hloov kho - N-terminus

Terminal Hloov kho - C-terminus

Qhov ntev (aa)

CP7-FP13-2 Peptide CAS 3032621-32-9

#CP7-FP13-2#, Dual-functional anti-Staphylococcus aureus peptide, Cyclic hybrid quorum sensing inhibitor, Anti-biofilm antimicrobial peptide

Antimicrobial peptide, Anti-Staphylococcus aureus, Quorum sensing inhibition, Biofilm blockade, Anti-virulence factor, MRSA tshuaj tiv thaiv kev tshawb fawb, Cutaneous anti- kis kab mob, Hauv vivo tshuaj tua kab mob

Cyclo(Leu-Leu-Phe-Ala-Dab)-Asn-Ile-Gly-Gly-Gly-Ile-Lys -Asn-Leu-Trp-Lys-Lys-Met-Ile-Lys-Leu-Trp-Tyr (Intramolecular cyclization ntawm Dab residue)

C₁₄₅H₂₂₄N₃₄O₃₁S₂

3002.62

3003.67

Tsis hloov

Dawb carboxyl pawg

23

Khoom Code

Qhov tshwm sim

Pom zoo Dissolution Protocol (los ntawm hnyav)

Solubility Reference

Tsis pom zoo Solvents

Ntev - Lub Sij Hawm Cia Cov Cai

Luv -Lub Sijhawm Cia Cov Cai

Kua Stability

Khoom hmoov ruaj khov

Muaj feem xyuam pH Range

PEB-CP7001

Dawb lyophilized hmoov

Dilute acetic acid, sterile ultrapure dej, nruab nrab PBS tsis; Tsis muaj zog acid suppresses methionine oxidation thiab txhim kho solubility

Ntau dua lossis sib npaug li 9 mg / mL (0.1% acetic acid aqueous tov)

Alkane cov kuab tshuaj, siab -concentration muaj zog alkali, muaj zog oxidizing kev daws teeb meem

-20 degree, kaw thiab aliquoted nyob rau hauv inert gas deb ntawm lub teeb, tsis txhob rov qab khov-thaw thiab oxidation

2-8 degree, siv nyob rau hauv 2 lub lis piam, npaj tshiab, tiv thaiv los ntawm lub teeb thiab cua

ruaj khov rau 16 h ntawm 4℃nyob rau hauv qhov tsaus ntuj kaw, methionine raug rau oxidative degradation

Ruaj khov rau 2 xyoos ntawm -20℃nyob rau hauv qhuav tsaus kaw

3.0-7.5

Khoom Code

Frontend Short Summary (rau cov npe tshawb nrhiav)

Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg

Cov cheeb tsam tshawb fawb (comma- cais)

Hom phiaj / Receptor

PEB-CP7001

Cyclic hybrid dual-function peptide CP7-FP13-2, exerts ob daim nyias nyias-lytic bactericidal kev ua thiab S.aureus quorum sensing suppression, potently inhibits biofilm tsim rau tshuaj-resistant MRSA anti-kev tshawb fawb

CP7-FP13-2 yog ib qho kev tsim khoom tsim tawm chimeric cyclic antimicrobial peptide, nrog tsib-cov tswv cuab cyclic domain mediated los ntawm Dab ntawm N-terminus, thiab cationic lysine / hydrophobic tryptophan enriched linear segment. Dual ua hauj lwm mechanisms: 1. Cationic amphipathic qauv tsom anionic staphylococcal membrane los cuam tshuam lipid bilayer thiab tua cov kab mob; 2. Competitively khi staphylococcal quorum sensing (QS) Agr receptor, suppresses qhia ntawm -hemolysin thiab virulence yam, blocks biofilm maturation. Tshaj li 90% biofilm inhibition ua tiav ntawm qhov tsis tshua muaj siab ntawm 8 ug / mL, qhov tseem ceeb hauv vivo kev tiv thaiv kab mob ua kom pom tseeb hauv cov qauv nas nrog tsawg kawg ntawm hemolytic toxicity. Dav siv nyob rau hauv cov tshiab txhuas compound kev loj hlob tawm tsam resistant S.aureus / MRSA, kab mob quorum sensing txoj kev tsom xam, biofilm tsim mechanism kev tshawb fawb, tshuaj pleev ib ce antibacterial formulation, peptide anti-virulence therapy thiab kis kab mob kev tshawb fawb.

Microbiology, Antibacterial pharmacology, Pharmaceutics, Infectious immunology, Ntuj tsim tshuaj, Molecular microbiology, Cutaneous pharmaceutics

Anionic teichoic acid ntawm Staphylococcus aureus membrane, S.aureus quorum sensing Agr receptor, Cov kab mob virulence regulatory pathway proteins

Khoom Code

Purity Detection Method

Molecular Weight Verification Method

Kev Tswj Xyuas Qhov Ntsuas

Impurity Control Standards

PEB-CP7001

HPLC High Performance Liquid Chromatography

ESI-MS Mass Spectrometry

Purity, dej ntsiab lus, Acetate, Heavy hlau, Oxidized methionine impurities, Truncated peptide impurities

Ib qho impurity Tsawg dua lossis sib npaug li 2%, Tag nrho cov impurities Tsawg dua lossis sib npaug li 5%

SKU Unique Code

Yam khoom Code

HPLC Purity

Ntim Specification

Lub Sijhawm Ua Haujlwm Ntau Lawm

Customizable

Optional Custom Modifications

Cov ntaub ntawv suav nrog

PEB-CP7001-98-1

PEB-CP7001

Ntau dua lossis sib npaug li 98%

1mg ib

3-7 hnub ua haujlwm

Yog lawm

Acetylation, Amidation, Fluorescent labeling, Biotin labeling, Cysteine ​​extension, Methionine hloov pauv

CoA, HPLC chromatogram, MS mass spectrum

PEB-CP7001-98-5

PEB-CP7001

Ntau dua lossis sib npaug li 98%

5mg ib

3-7 hnub ua haujlwm

Yog lawm

Acetylation, Amidation, Fluorescent labeling, Biotin labeling, Cysteine ​​extension, Methionine hloov pauv

CoA, HPLC chromatogram, MS mass spectrum

PEB-CP7001-95-1

PEB-CP7001

Ntau dua lossis sib npaug li 95%

1mg ib

3-7 hnub ua haujlwm

Yog lawm

Acetylation, Amidation, Fluorescent labeling, Biotin labeling, Cysteine ​​extension, Methionine hloov pauv

CoA, HPLC chromatogram, MS mass spectrum