Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov muag khoom ntawm cas 1139931-15-9 (rfr)4xb hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 1139931-15-9 (rfr) 4xb los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Kev piav qhia | (RFR) 4XB (CAS: 1139931-15-9) yog cationic membrane-peptide penetrating muaj li ntawm plaub tandem RFR (arginine-phenylalanine-}}} arginine) rov units, nrog ib tug C{{13}xanoic acid, amino acids 6-aminohexanoic acid) spacer txuas rau -alanine (Ala). Nws cov kab ke RFRRFRRFRRFR muaj 8 arginine residues (zoo them) thiab 4 phenylalanine residues (hydrophobic aromatic), nthuav tawm cov qauv cationic amphipathic. Cov pab pawg guanidinium ntawm arginine muab muaj zog electrostatic kev sib cuam tshuam nrog anionic membrane phospholipids thiab lipopolysaccharide (LPS), thaum lub nplhaib aromatic ntawm phenylalanine muab hydrophobic insertion thiab membrane perturbation muaj peev xwm. Lub Ahx-Ala tail (XB) ua hauj lwm raws li ib tug saj zawg zog spacer rau conjugation rau antisense oligonucleotides (xws li, phosphorodiamidate morpholino oligomers, PMOs). Lub luag haujlwm tseem ceeb ntawm (RFR) 4XB yog nqa nws cov khoom thauj (antisense oligomers) hla cov txheej txheem ntawm cov kab mob Gram-negative, ua rau nws yog ib qho tseem ceeb ntawm kev xa cov vector hauv kev kho cov kab mob antisense. Cov kev tshawb fawb tau pom tias (RFR) 4XB-PMO conjugates zoo inhibit gene qhia hauv Escherichia coli ob qho tib si hauv vitro thiab hauv vivo, nrog lub peev xwm rau kev tsim cov tshuaj tua kab mob tshiab. |
Product Basic Information Table
| Lub npe txheem | Cov npe | CAS Nr. | Core Function Tags | Hom qauv | Molecular Formula | Exact Mass (Da) | Daim ntawv ntsev | Sib Nqus Ntev |
| (RFR) 4 XB | Tetra-Branched RFR peptide; tetravalent Arg-Phe-Arg peptide | 1139931-15-9 | Multivalent targeting, integrin binding, cell penetration txhim khu kev qha | Tetra-branched lysine- scaffold multivalent peptide | C₈₄H₁₂₈N₃₂O₁₄ | 1841 | Trifluoroacetate (TFA) | 12 (tetra-branched tripeptide) |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-RFR004 | Dawb hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot rau cia. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau shipping ntawm ambient kub. | ruaj khov rau 7 hnub ntawm 4 degree. TFA ntsev yog dawb do soluble nyob rau hauv dej, dilute acetic acid thiab acidic buffers. Zoo stability ntawm multivalent cationic peptide nyob rau hauv acidic tej yam kev mob; tsub nqi neutralization thiab poob kev ua si nyob rau hauv muaj zog alkaline tej yam kev mob. | Stable for 2 years at -20℃, dry and protected from light. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-RFR004 | Tetra-branched (RFR)4XB khi integrins multivalently rau kev txhim kho lub hom phiaj & kev nkag mus | (RFR)4XB yog tetravalent RFR peptide raws li tetra-branched lysine scaffold. Txhua ceg nthuav qhia Arg-Phe-Arg ib ntus uas nws tus kheej khi integrin receptors thiab anionic phospholipids ntawm lub xov tooj ntawm tes. Cov nyhuv tetravalent synergistic ua rau muaj kev sib koom ua ke ntau dua thiab kev nkag mus ntawm tes ua haujlwm zoo dua li monomeric linear RFR. Nws yog siv nyob rau hauv cov qog nqaij hlav xa mus, kev nkag mus ntawm tes ntawm tes thiab kev tshawb fawb integrin. | Tumor targeted therapy, integrin biology, CPP technology, multivalent ligand kev tshawb fawb, tsom xa tshuaj | Integrins v ₃ / 5 ₁; multivalent kev koom tes binding; electrostatic adsorption ntawm daim nyias nyias |
Cim npe nrov: cas 1139931-15-9 (rfr)4xb, Tuam Tshoj cas 1139931-15-9 (rfr)4xb manufacturers, lwm tus, Hoobkas
