Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 380480-75-1 pptg20 hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 380480-75-1 pptg20 los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Kev piav qhia | ppTG20 (CAS: 380480-75-}1) yog 20-amino acid theem nrab amphipathic cell-peptide thiab qhov ua kom zoo tshaj plaws ntawm ppTG1 carrier peptide. Nws cov kab ke GLFRALLRLLRSLWRLLLRA muaj 4 arginine residues (zoo them) thiab ntau yam hydrophobic residues suav nrog leucine, phenylalanine, thiab tryptophan, txais yuav ib qho -helical conformation nyob rau hauv daim nyias nyias ib puag ncig nrog ib txwm amphipathicity theem nrab hydrophobic: arginine muab faib rau ntawm ib lub ntsej muag residue thiab zoo membrane anchoring thiab insertion muaj peev xwm. ppTG peptide series yog cov khoom thauj khoom nruab nrab ntawm amphipathic peptides tsim los ntawm fusion peptide JTS1, tshwj xeeb tshaj yog rau nucleic acid xa. ppTG20 cov ntaub ntawv ruaj khov nanocomplexes (polyplexes) nrog cov nqi tsis zoo DNA / siRNA los ntawm kev sib cuam tshuam electrostatic, tiv thaiv nucleic acids los ntawm nuclease degradation thiab mediating cellular uptake los ntawm endocytosis, ua raws li endosomal khiav los ntawm "proton sponge effect" lossis membrane fusion mechanism tso tawm nucleic acids rau hauv cytoplasm. Piv rau qhov zoo sib xws ntawm cov amphipathic peptides xws li CADY, ppTG20 muaj qhov zoo sib npaug ntawm cov noob xa khoom zoo thiab cytotoxicity, ua rau nws yog ib qho tseem ceeb uas tsis yog kab mob gene xa vector cuab yeej hauv kev kho noob, tshuaj tiv thaiv DNA, thiab RNA cuam tshuam kev tshawb fawb. |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| npg 20 | Transglutaminase substrate peptide ppTG20; protein cross-txuas kev ua haujlwm peptide | Transglutaminase substrate, protein covalent cross-txuas, kev hloov kho cov ntaub so ntswg engineering, biomaterial functionalization | Transglutaminase (TGase)- tshwj xeeb 20-mer substrate peptide nrog cov yam ntxwv glutamine residues; enzymatically cross-linked rau lysine residues ntawm cov proteins thiab biomaterials ntawm isopeptide bonds | C₉₂H₁₄₉N₂₅O₂₇ | 2048.13 | ~2049.5 | Acetate | 20 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-PPT020 | Dawb hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot rau cia. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau shipping ntawm ambient kub. | ruaj khov rau 7 hnub ntawm 4 degree. Soluble hauv dej, dilute acetic acid thiab nruab nrab buffers. Tsis txhob premixing nrog transglutaminase; enzymatic cross- txuas tuaj yeem tshwm sim ntawm qhov kub thiab txias. | ruaj khov rau 2 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-PPT020 | ppTG20 transglutaminase substrate peptide mediates covalent ntoo khaub lig-txuas cov proteins & cov ntaub ntawv | ppTG20 yog ib qho tshwj xeeb substrate peptide rau transglutaminase (TGase), muaj cov yam ntxwv glutamine residues nyob rau hauv ib ntus. Nws yog tshwj xeeb lees paub thiab catalyzed los ntawm transglutaminase, tsim isopeptide bonds nrog lysine residues ntawm cov proteins, peptides thiab biomaterial nto rau covalent ntoo khaub lig- txuas. Nws yog siv rau hauv qhov chaw protein-kev hloov kho tshwj xeeb, cov ntaub so ntswg engineering scaffold nto functionalization, hydrogel cross- txuas thiab biomaterial hloov kho. | Protein modification chemistry, cov ntaub so ntswg engineering & biomaterials, enzyme-catalyzed cross- txuas, hydrogel npaj, protein immobilization | Transglutaminase (TGase) active chaw; glutamine-lysine isopeptide daim ntawv cog lus; biomaterial nto hloov kho |
Cim npe nrov: CAS 380480-75-1 pptg20, Tuam Tshoj cas 380480-75-1 pptg20 manufacturers, lwm tus, Hoobkas
