Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 1360823-60-4 gh625 hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 1360823-60-4 gh625 los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Kev piav qhia | gH625 (CAS: 1360823-60-4) is a 20-amino acid virus-derived cell-peptide derived los ntawm residues 625-644 (membrane) hom kab mob no ntawm{2 1 (HSV-1) lub hnab ntawv glycoprotein H (gH). Nws cov kab ke HGLASTLTRWAHYNALIRAF txais yuav ib qho -helical conformation nyob rau hauv membrane ib puag ncig nrog pronounced amphipathicity thiab membrane fusion kev ua. Lub npe gH625 muab los ntawm nws txoj haujlwm pib (residue 625) hauv gH protein. Raws li lub luag haujlwm tseem ceeb ntawm cov kab mob sib xyaw ua ke cov protein, gH625 zoo nkag mus rau hauv cov cell membranes thiab xa ntau cov khoom sib txuas (xws li cov proteins, peptides, quantum dots, nanoparticles, thiab siRNA) rau hauv cytoplasm. Ib qho tseem ceeb ntawm gH625 yog nws lub peev xwm los hla cov ntshav-hlwb barrier (BBB), nkag mus rau nas hlwb cov ntaub so ntswg hauv vivo yam tsis muaj toxicity tseem ceeb, ua rau nws muaj kev cia siab rau lub hauv paus paj hlwb (CNS) xa tshuaj. Tsis tas li ntawd, gH625 nthuav tawm cov tshuaj tua kab mob thiab tshuaj tua kab mob, muaj peev xwm tshem tawm Candida albicans persister cell biofilms. gH625 tau siv nyob rau hauv ntau qhov chaw suav nrog lub hlwb xa cov neuroprotective peptide PACAP, hauv vitro Parkinson tus kab mob kev tshawb fawb, thiab siRNA xa, ua rau nws yog ib qho tseem ceeb peptide peptide rau cov ntshav-hlwb barrier nkag mus thiab lub hlwb-targeted tshuaj xa mus tshawb fawb. |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| hwv 625 | gH625 cell- nkag mus rau peptide; histone- tau txais pH- teb peptide | Cell-peptide penetrating, pH- teb tus me nyuam, intracellular nucleic acid/protein xa, gene transfection | Cationic amphiphilic 25-mer peptide muab tau los ntawm histone H2A; nplua nuj nyob rau hauv histidine thiab arginine nrog pH-responsive membrane fusion kev ua, zoo xa nucleic acids, proteins thiab lwm yam biomacromolecules rau hauv cov hlwb. | C₁₃₀H₂₀₉N₄₃O₃₀ | 2908.59 | ~2910.1 | Acetate | 25 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-GH625 | Dawb hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot rau cia. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau shipping ntawm ambient kub. | ruaj khov rau 7 hnub ntawm 4 degree. pH- teb peptide: protonated thiab soluble heev nyob rau hauv acidic tej yam kev mob; deprotonated nrog txhim khu kev ua haujlwm membrane thiab sib dhos nyiam ntawm nruab nrab rau alkaline pH. | ruaj khov rau 2 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-GH625 | gH625 pH- teb CPP, histone- muab tau, ua tau zoo xa biomacromolecules | gH625 yog pH-tej xovtooj teb-peptide nkag tau los ntawm histone H2A, nplua nuj nyob rau hauv protonatable histidine thiab cationic arginine. Nws yog protonated thiab soluble nyob rau hauv acidic tej yam kev mob, thiab ua rau daim nyias nyias fusion thaum pH txo nyob rau hauv endosomes tom qab cellular nkag, zoo tso cargoes. Nws xa cov plasmid DNA, mRNA, cov proteins thiab cov tshuaj tiv thaiv nrog kev ua haujlwm siab thiab muaj peev xwm ua kom muaj peev xwm khiav tawm, siv tau rau hauv kev kho noob caj noob ces thiab kev tshawb nrhiav cov protein. | Gene transfection & gene therapy, pH- teb lub tshuab xa khoom, kev xa cov protein nyob hauv lub cev, kev tshawb fawb endosomal khiav, CPP thev naus laus zis | Histidine protonation / deprotonation; membrane fusion mechanism; endosomal txoj kev khiav tawm |
Cim npe nrov: CAS 1360823-60-4 gh625, Tuam Tshoj cas 1360823-60-4 gh625 manufacturers, lwm tus, Hoobkas
