Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov muag khoom ntawm n188 hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau kev lag luam wholesale bulk zoo n188 los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | N188 |
| Kev piav qhia | N188 yog radioligand precursor raws li bicyclic peptide qaum, tsom Nectin -4 - cell adhesion molecule overexpressed nyob rau hauv ntau yam malignancies (urothelial carcinoma, cancer mis, mob ntsws cancer, thiab lwm yam). Lub bicyclic conformation ntawm N188 yog stabilized los ntawm ob disulfide bonds tsim los ntawm plaub cysteine residues. Qhov kev txwv tsis sib haum no ua rau muaj kev sib raug zoo thiab tshwj xeeb rau Nectin-4 khi thaum txhim kho hauv vivo proteolytic stability. Piv rau linear peptides, bicyclic peptides muab cov ntaub so ntswg nkag tau zoo dua, txo qis kev tiv thaiv kab mob, thiab ntev dua hauv vivo ib nrab-lub neej. N188 tuaj yeem sib txuas rau radionuclides (⁶⁸Ga, ⁶⁴Cu, ¹⁷⁷Lu, thiab lwm yam) los ntawm chelating moieties (DOTA, NOTA) rau PET / SPECT imaging thiab tsom radionuclide kho ntawm Nectin{15}}4{{17} zoo. Cov kev tshawb fawb ua ntej pom tau hais tias ⁶⁸Ga- thiab ⁶⁴Cu-labeled N188 derivatives nthuav tawm cov qog nqaij hlav zoo heev thiab lub hom phiaj-rau-tsis pom qhov sib piv hauv cov qauv mob qog noj ntshav. |
| Peptide Purity (HPLC, %) | Ntau dua lossis sib npaug li 95% |
| Cov mis mos molecular | C₁₁₃H₁₅₃N₂₇O₃₃S₄ |
| Molecular Luj (Da) | 2545.85 Da (dawb acid) |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| N188 | N188 anti- qog peptide; p53 txoj kev ua kom peptide | Anti- qog peptide, p53 txoj kev ua kom, qog cell apoptosis induction, proliferation inhibition | Linear cationic functional peptide uas tshwj xeeb khi MDM2, thaiv MDM2-mediated p53 ubiquitination thiab degradation, restores p53 qog suppressor muaj nuj nqi, induces cell voj voog ntes thiab apoptosis | C₃₆H₅₉N₁₁O₇ | 753.45 | ~754.0 | Acetate | 9 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-N18801 | Dawb hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot rau cia. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau shipping ntawm ambient kub. | ruaj khov rau 7 hnub ntawm 4 degree. Acetate ntsev yog dawb do soluble nyob rau hauv dilute acetic acid, acidic buffers thiab dej. Zoo stability ntawm cationic peptide nyob rau hauv acidic rau nruab nrab tej yam kev mob; tsub nqi neutralization thiab poob kev ua si nyob rau hauv muaj zog alkaline tej yam kev mob. | ruaj khov rau 2 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov Cheeb Tsam Tshawb Fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-N18801 | N188 anti- qog peptide blocks MDM2-p53 kev sib cuam tshuam los qhib p53 qog suppressor txoj hauv kev | N188 yog ib qho tshuaj tiv thaiv- qog ua haujlwm peptide tsom rau MDM2-p53 kev cuam tshuam. Nws sib tw khi rau p53-binding hnab tshos ntawm MDM2, thaiv MDM2-mediated p53 ubiquitination thiab degradation, restores intracellular p53 protein theem, thiab activates p53-mediated qog suppressor txoj kev xws li cell voj voog ntes thiab apoptosis. Nws xaiv induces qog cell apoptosis nrog tsawg toxicity rau lub cev ib txwm, ua ib qho tseem ceeb cov cuab yeej peptide rau p53 txoj kev tshawb fawb thiab tshuaj tiv thaiv qog. | Kev tshawb fawb qog noj tshuaj, p53 txoj kev kawm, tiv thaiv - qog peptide kev loj hlob, protein-protein interaction inhibitor, kev tshawb fawb apoptosis | MDM2-p53 qhov chaw sib cuam tshuam; cell voj voog checkpoint; apoptotic signaling txoj kev |
Cim npe nrov: n188, Tuam Tshoj n188 manufacturers, lwm tus neeg, Hoobkas
