Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov chaw muag khoom ntawm cas 2225868-19-7 123b9 hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 2225868-19-7 123b9 los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS 2225868-19-7 123B9 |
| Kev piav qhia | 123B9 yog ib qho muaj zog thiab xaiv EphA2 (Ephrin hom-A receptor 2) agonist peptide, CAS 2225868-19-7. Nws cov kab ke yog {2-(3-chloro-4-fluorophenoxy)acetic acid}-Ser-Ala-Tyr-Pro-Asp-Ser-Val-Pro-{Nle}-{Hsr}-Ser-Ser-Val-Pro-{Nle}-{Hsr}-Ser-, NHration: N-terminus yog hloov kho hydrophobically nrog 2-(3-chloro-4-fluorophenoxy)acetic acid (CFPA, ib qho aryloxyacetic acid uas muaj chloro-fluoro hloov benzene nplhaib), txhim kho kev sib raug zoo nrog cov receptor pocket; non-natural amino acids xws li norleucine (Nle, uas tsis yog-oxidizable methionine analog) thiab homoserine (Hsr) tau nkag mus rau hauv cov saw peptide, txhim kho metabolic stability thiab receptor selectivity; C-terminal amidation ntxiv txhim kho kev ua haujlwm lom neeg thiab ua rau muaj zog tiv thaiv kab mob . 123B9 xaiv khi cov ligand-binding domain ntawm EphA2 tyrosine kinase receptor nrog Kd ntawm 4.0 μM, ua kom cov dej ntws qis ntawm EphA2 receptor. Qhov tseem ceeb, 123B9 tsis txaus siab cuam tshuam cov ligand-binding domains ntawm cov feem cuam tshuam nrog EphA3 thiab EphA4 receptors, ua rau pom zoo subtype selectivity. EphA2 receptor yog overexpressed nyob rau hauv ntau yam malignancies (xws li lub mis, prostate, ntsws, thiab zes qe menyuam qog noj ntshav), ze ze nrog qog invasion, metastasis, thiab angiogenesis. Raws li tus neeg mob qog-homing, 123B9 tuaj yeem siv rau hauv kev xa cov tshuaj qog nqaij hlav, qog cov duab sojntsuam, kev tshawb nrhiav EphA2 signaling pathway research, thiab anti-tumor therapeutic strategy exploration. |
| Peptide Purity (HPLC, %) | Ntau dua lossis sib npaug li 98% |
| Cov mis mos molecular | C₅₈H₈₂ClFN₁₂O₂₀ |
| Molecular Luj (Da) | 1321.79 |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| 123B9 | c-Met targeting peptide 123B9; HGF receptor antagonist peptide | Receptor antagonist peptide, tiv thaiv -metastasis, cell invasion inhibition, qog targeting, anti-fibrosis | c-Met/HGFR-cov peptide tshwj xeeb uas sib tw ua ke rau lub extracellular domain ntawm c-Met, blocks HGF-induced receptor activation thiab downstream signaling, thiab inhibits qog cell migration, ntxeem tau thiab angiogenesis | C₅₅H₇₉N₁₅O₁₀ | 1121.61 | ~1122.4 | Acetate | 9 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-12B009 | Dawb hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot rau cia. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau shipping ntawm ambient kub. | ruaj khov rau 7 hnub ntawm 4 degree. Acetate ntsev yog dawb do soluble hauv dej, dilute acetic acid thiab PBS. Zoo stability nyob rau hauv nruab nrab tej yam kev mob; conformational hloov thiab khi kev ua si poob nyob rau hauv muaj zog alkaline tej yam kev mob. | ruaj khov rau 2 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-12B009 | 123B9 c-Met targeting peptide blocks HGF receptor to inhibit qog invasion & metastasis | 123B9 yog ac-Met- tshwj xeeb antagonist peptide uas sib tw ua ke rau cov ligand extracellular-binding domain ntawm c-Met (hepatocyte kev loj hlob yam receptor). Nws thaiv HGF-induced receptor dimerization thiab phosphorylation, thiab inhibits downstream pro-invasive signaling pathways xws li PI3K/Akt thiab MAPK, zoo suppressing qog cell migration, ntxeem tau thiab angiogenesis. Nws yog ib qho cuab yeej tseem ceeb rau c-Kev tshawb fawb txog kev sib ntsib thiab kev txhim kho tshuaj tiv thaiv kab mob metastatic. | Tumor invasion & metastasis tshawb fawb, c-Met signaling pathway, anti-cancer drug development, receptor antagonist study, anti- tshawb fawb fibrosis | Hepatocyte growth factor receptor (c-Met/HGFR); kev sib tw HGF antagonism; PI3K/Akt signaling pathway |
Cim npe nrov: cas 2225868-19-7 123b9, China cas 2225868-19-7 123b9 manufacturers, lwm tus neeg, hoobkas
