Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 863608-35-9 pep-1-cysteamine hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 863608-35-9 pep-1-cysteamine los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Kev piav qhia | Pep-1-Cysteamine (CAS: 863608-35-9) yog 21-amino acid chimeric cell- nkag peptide nrog cov kab ke Ac-KETWWETWWTEWSQPKKKRKV amphipathicity. Pep-1 muaj peb lub luag haujlwm: (1) N-terminal hydrophobic domain (KETWWETWWTEW), nplua nuj hauv tryptophan (Trp, W, 5 tag nrho) thiab glutamic acid residues; lub indole rings ntawm tryptophan muaj zog hydrophobicity thiab daim nyias nyias -anchoring muaj peev xwm, ntxig rau hauv cell membrane lipid bilayer; (2) nruab nrab hydrophilic spacer cheeb tsam (SQP), muab kev hloov pauv yooj yim; (3) C-terminal hydrophilic nuclear localization signal domain (KKKRKV), muab los ntawm NLS ib ntus ntawm SV40 Loj T antigen, nplua nuj nyob hauv cov amino acids yooj yim, muab cov nqi zoo thiab kev sib haum xeeb nuclear localization. N-terminal acetylation thiab C-terminal cysteamine hloov kho ntxiv txhim kho peptide's amphipathicity thiab stability. Ib qho tseem ceeb ntawm Pep-1 yog nws lub peev xwm los tsim cov khoom ruaj khov nrog cov khoom thauj khoom xws li macromolecular xws li cov proteins los ntawm kev sib cuam tshuam tsis zoo (hydrophobic thiab electrostatic kev sib cuam tshuam), kev sib haum xeeb ntawm cov protein hauv lub cev tsis muaj tshuaj lom neeg, ua rau nws tsim tshwj xeeb rau kev xa cov protein ntau thiab cov enzymes rhiab rau kev hloov tshuaj lom neeg. Pep-1 tuaj yeem nkag mus rau hauv cov cell membranes ntawm ntau hom tsiaj, xa cov protein ntau, cov tshuaj tiv thaiv kab mob, peptides, thiab nucleic acids rau hauv cov hlwb yam tsis muaj kev cuam tshuam loj rau ntawm tes. Pep-1 yog dav siv rau: (1) protein transduction thiab intracellular protein muaj nuj nqi kev tshawb fawb; (2) intracellular xa cov enzymes thiab cov tshuaj tiv thaiv kab mob; (3) xa cov gene-editing proteins (xws li CRISPR/Cas9); (4) cell-penetrating peptide uptake mechanism thiab membrane kev sib cuam tshuam kev tshawb fawb; (5) kev txhim kho ntawm peptide-raws li cov protein xa khoom. Pep-1 yog ib qho cuab yeej tseem ceeb rau kev kawm tsis yog-covalent protein hloov pauv thiab txhim kho kev kho cov protein hauv lub cev. |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| Pep-1-Cysteamine | Pep-1 cysteamine hloov peptide; thiol-activated cell-penetrating peptide | Kev nkag mus ntawm tes, thiol site- tshwj xeeb conjugation, protein/drug oriented ligation, tus xa khoom xa tuaj | Pep-1 cell- nkag mus rau peptide C-terminally hloov nrog cysteamine; khaws cov kev nkag mus tau zoo, thiab lub davhlau ya nyob twg dawb thiol ua rau qhov chaw tshwj xeeb sib txuas ntawm cov protein, tshuaj thiab nanoparticles ntawm disulfide bonds | C₁₁₅H₁₈₅N₃₅O₂₅S | 2587.39 | ~2589.0 | Acetate | 21 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-PEP001 | Dawb hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb, nyob rau hauv inert gas. Aliquot rau cia. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; tiv thaiv cov pa oxygen thaum thauj khoom. | ruaj khov rau 7 hnub ntawm 4 degree. Soluble nyob rau hauv dilute acetic acid thiab acidic buffers. Terminal dawb thiol yog rhiab heev rau oxygen thiab hlau ions; Nws yooj yim rau oxidation thiab disulfide tsim. Tsis txhob sib xyaw nrog oxidants. | ruaj khov rau 2 xyoos ntawm -20 degree, qhuav, tiv thaiv los ntawm lub teeb thiab nyob rau hauv inert roj. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-PEP001 | Pep-1-cysteamine ua ke kom muaj txiaj ntsig ntawm tes nkag tau & qhov chaw tshwj xeeb thiol conjugation | Pep-1-Cysteamine yog ib qho thiol- hloov pauv cell-peptide. Lub Pep-1 ntu tau zoo nkag mus rau cov cell membranes ntawm hydrophobic insertion thiab electrostatic kev sib cuam tshuam. Lub davhlau ya nyob twg dawb thiol ntawm cysteamine enables site-specific conjugation ntawm antibodies, protein toxins thiab nanoparticles ntawm disulfide bonds rau oriented kev hloov kho ntawm lub tsheb xa khoom. | Protein drug conjugation, targeted drug development, cell- nkag mus rau tus me nyuam, kev hloov kho nanocarrier, qhov chaw- kev hloov kho tshuaj tshwj xeeb | Phospholipid bilayer; thiol disulfide conjugation; Pep-1-mediated transmembrane xa |
Cim npe nrov: CAS 863608-35-9 pep-1-cysteamine, Tuam Tshoj cas 863608-35-9 pep-1-cysteamine manufacturers, lwm tus neeg, Hoobkas
