Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov chaw muag khoom ntawm nota-pep-1l hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau kev lag luam wholesale bulk zoo nota-pep-1l los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | NOTA-Pep-1L |
| Kev piav qhia | NOTA-Pep-1L yog radioligand precursor nyob rau hauv uas NOTA (1,4,7-triazacyclononane-1,4,7-triacetic acid) macrocyclic chelator yog conjugated rau lub hom phiaj Pep-18} ntawm a lysine. Pep{19}}1L yog ib qho disulfide-bridged cyclic peptide ligand (Cys2–Cys10) nrog rau cov txheej txheem tseem ceeb Ala-Cys-Gly-Glu-Met-Gly-Trp-Val-Arg-Cys, txuas los ntawm GGG-Ser{-Trp-Val-Arg-Cys, txuas los ntawm GGG-Ser{{{32}L flexer 4}Ahx NOTA- hloov kho lysine, nrog C-terminal amidation. NOTA yog cuaj tus neeg koom nrog triazamacrocyclic chelator uas nthuav tawm kev sib koom tes zoo nrog radionuclides xws li ⁶⁸Ga, ⁶⁴Cu, thiab ¹⁸F-AlF, tshwj xeeb tshaj yog tsim rau ⁶⁸Ga daim ntawv lo (ceev chav tsev kub kub). NOTA-Pep-1L tuaj yeem siv rau PET cov duab kev tshawb fawb ntawm lub hom phiaj molecules, qhov twg nws cov disulfide-cyclized conformation confers siab lub hom phiaj affinity thiab tshwj xeeb, ua rau nws yog ib qho tseem ceeb cov cuab yeej reagent nyob rau hauv precision nuclear tshuaj thiab tsom theranostics. |
| Peptide Purity (HPLC, %) | Ntau dua lossis sib npaug li 95% |
| Cov mis mos molecular | C₈₄H₁₃₉N₂₇O₂₅S₃ |
| Molecular Luj (Da) | 2023.38 Nws |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| NOTA-Pep-1L | NOTA- phiaj peptide 1L; PET daim duab peptide | Cov qog nqaij hlav- phiaj xwm duab, PET diagnostic reagent, NOTA-chelating peptide, ⁶⁸Ga imaging precursor | NOTA (1,4,7-triazacyclononane-1,4,7-triacetic acid) macrocyclic chelator conjugated nrog lub hom phiaj peptide Pep-1L; NOTA sai sai chelates ⁶⁸Ga ntawm nruab nrab pH; Pep-1L kho cov qog nqaij hlav ntxiv | C₃₈H₆₂N₈O₁₀ | 794.46 | ~795.0 | Acetate | 7 (7-mer + NOTA) |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-NOT001 | Dawb hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot rau cia. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau shipping ntawm ambient kub. | ruaj khov rau 7 hnub ntawm 4 degree. Dawb soluble hauv dej, dilute acetic acid thiab nruab nrab buffers. Kev ua haujlwm zoo tshaj plaws ntawm NOTA ntawm tsis muaj zog acidic rau nruab nrab pH; chelation efficiency txo qis nyob rau hauv muaj zog alkaline tej yam kev mob. | ruaj khov rau 2 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov Cheeb Tsam Tshawb Fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-NOT001 | NOTA-Pep-1L chelates ⁶⁸Ga ua tau zoo ntawm pH nruab nrab rau qog nqaij hlav PET duab | NOTA-Pep-1L yog qog nqaij hlav-PET imaging precursor raws li NOTA macrocycle. Raws li 9-tus tswvcuab triacetic acid chelator, NOTA nthuav tawm chelation kinetics sai dua thiab ruaj khov dua rau ⁶⁸Ga dua li DOTA nyob rau hauv nruab nrab lub cev muaj zog, ua rau chav ntsuas kub ceev ceev. Pep-1L peptide mediates lub hom phiaj txhawb kev loj hlob ntawm cov qog nqaij hlav. Tom qab ntawv sau npe, nws yog siv rau PET kuaj pom thiab ntsuas kev ua tau zoo ntawm ntau yam qog nqaij hlav. | Nuclear tshuaj ntsuam xyuas, qog PET duab, tsom kev txhim kho tshuaj, radiochemistry, chelation technology tshawb fawb | qog hom phiaj antigen; NOTA hlau chelation site; ⁶⁸Ga- npe PET |
Cim npe nrov: nota-pep-1l, Tuam Tshoj nota-pep-1l manufacturers, lwm tus neeg, Hoobkas
