Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov tuam txhab ua lag luam thiab cov chaw muag khoom ntawm dota-octreotide hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo dota-octreotide los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | DOTA-Octreotide |
| Kev piav qhia | DOTA-Octreotide (CAS: 209277-09-8) yog radioligand precursor uas DOTA macrocyclic chelator yog conjugated rau N-terminus ntawm octreotide, ib qho hluavtaws somatostatin analog. Octreotide yog ib qho 8-amino acid peptide nrog qhov sib lawv liag {d-Phe}-Cys-Phe-{d-Trp}-Lys-Thr-Cys-{Threoninolic confides for7, qhov twg Cys-{Threoninols a2Cyformic confysation thiab C-terminus yog txo qis threoninol. Octreotide khi nrog siab affinity rau somatostatin receptors (SSTR, tshwj xeeb tshaj yog SSTR2), uas yog overexpressed nyob rau saum npoo ntawm ntau yam neuroendocrine hlav (carcinoids, islet cell hlav, pheochromocytomas, thiab lwm yam). DOTA conjugation enables labeling with ⁶⁸Ga (PET imaging), ⁹⁰Y/¹⁷⁷Lu (peptide receptor radionuclide therapy, PRRT), thiab lwm yam radionuclides rau kev kuaj pom thiab kev kho mob ntawm cov qog neuroendocrine. Piv rau cov haiv neeg somatostatin, octreotide muaj ntev dua nyob rau hauv vivo ib nrab-lub neej thiab siab dua receptor selectivity. |
| Peptide Purity (HPLC, %) | Ntau dua lossis sib npaug li 95% |
| Cov mis mos molecular | C₆₅H₉₂N₁₄O₁₇S₂ |
| Molecular Luj (Da) | 1405.64 Nws |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| DOTA-Octreotide | DOTA-octreotide; SSTR-tig peptide; DOTATOC | Neuroendocrine qog imaging / kho, somatostatin receptor targeting, nuclear tshuaj theranostic peptide | N-terminal DOTA hloov kho octreotide (8-mer with disulfide conformational constraint); high-affinity aiming ntawm SSTR2; DOTA chelates ⁶⁸Ga / ¹⁷⁷Lu / ⁹⁰Y | C₆₅H₈₉N₁₃O₁₉S₂ | 1435.59 | ~1436.7 | Acetate | 8 (8-mer + DOTA, disulfide-cyclized) |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-DOC001 | Dawb hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot rau cia. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau shipping ntawm ambient kub. | ruaj khov rau 7 hnub ntawm 4 degree. Soluble nyob rau hauv dilute acetic acid, ib txwm saline thiab PBS. Disulfide daim ntawv cog lus yog rhiab heev rau muaj zog txo cov neeg ua haujlwm thiab kub siab; nquag mus cleavage thiab inactivation. Tsis txhob siab -concentration thiol reagents. | ruaj khov rau 2 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-DOC001 | DOTA-octreotide (DOTATOC) lub hom phiaj SSTR2 rau neuroendocrine qog theranostics | DOTA-Octreotide (DOTATOC) yog ib qho classic somatostatin receptor-targeted theranostic peptide. Cov octreotide moiety khi nrog siab affinity rau somatostatin receptor SSTR2 overexpressed ntawm neuroendocrine hlav, kho receptors -mediated endocytosis thiab tsub zuj zuj. N-terminal DOTA macrocycle stably chelates ⁶⁸Ga (PET imaging), ¹⁷⁷Lu / ⁹⁰Y (radiotherapy). Nws yog ib qho ntawm cov kub - tus qauv reagents rau kev kuaj mob, staging, kev soj ntsuam kev ua tau zoo thiab lub hom phiaj siv hluav taws xob kho mob ntawm cov qog neuroendocrine. | Neuroendocrine qog theranostics, somatostatin receptor kev tshawb fawb, kev tshuaj ntsuam xyuas cov tshuaj nuclear, tsom kwm xov tooj cua, peptide receptor targeting | Somatostatin receptor 2 (SSTR2); DOTA hlau chelation site; receptor-mediated endocytosis |
Cim npe nrov: dota{0}}octreotide, Tuam Tshoj dota-octreotide manufacturers, lwm tus neeg, Hoobkas
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