![CAS 2767993-86-0 Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)]](/uploads/48442/cas-2767993-86-0-cyclo-arg-gly-asp-d-phe-lys9bd20.png)
Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov tuam txhab ua lag luam thiab cov chaw muag khoom ntawm cas 2767993-86-0 cyclo[arg-gly-asp-d-phe-lys(azide)] hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale tej yam zoo li cas 2767993-86-0 cyclo[arg-gly-asp-d-phe-lys(azide)] los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] |
| Kev piav qhia | Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] (Cyclo[RGDfK(Azide)]), CAS 2767993-86-}0, yog ib qho azide variation ntawm classical 3 siab-affinity ligand c(RGDfK). Nws cov molecule yog lub taub hau-rau-tail cyclized pentapeptide nrog core sequence -Arg-Gly-Asp-D-Phe-Lys-, nyob rau hauv uas cov 2} pawg 2am{20} tsim ib daim ntawv cog lus amide nrog 3-azidopropanoic acid, qhia txog pawg azide davhlau ya nyob twg (-N₃). RGD (Arg-Gly-Asp) tripeptide motif yog ib qho kev khaws cia integrin kev lees paub nyob rau hauv extracellular matrix proteins, tshwj xeeb binding integrin v 3 receptors uas tau nthuav tawm heev ntawm cov qog vascular endothelial hlwb thiab ntau yam qog nqaij hlav, kev sib kho ntawm tes, thiab kev sib koom tes ntawm tes. Kev taw qhia ntawm D-phenylalanine (D-Phe) ua rau muaj kev txhim kho metabolic stability thiab receptor selectivity ntawm cyclic peptide, muab c(RGDfK) ntau dua affinity rau v 3 dua li lwm yam integrin subtypes. Cov pab pawg azide ntawm lysine sab saw muab ib qhov chaw reactive rau nyem chemistry, ua kom muaj txiaj ntsig zoo thiab xaiv tooj liab zoo heev -catalyzed azide-alkyne cycloaddition (CuAAC) nrog alkyne-muaj cov molecules nyob rau hauv lub xub ntiag ntawm tooj liab, 37} azide-alkyne cycloaddition (SPAAC) nrog DBCO/BCN nyob rau hauv tooj liab-dawb tej yam kev mob, tso cai rau site- tshwj xeeb conjugation ntawm functional molecules xws li tshuaj, fluorescent probes, thiab nanoparticles rau lub cRGD lub hom phiaj scaffold. Cov peptide no tau siv dav hauv kev xa cov tshuaj qog nqaij hlav (xws li peptide-drug conjugates, nanomedicines), qog duab sojntsuam (fluorescence, radionuclide, MRI), integrin receptor-mediated endocytosis txoj kev tshawb fawb, thiab nyem chemistry bioconjugation txoj kev txhim kho. |
| Peptide Purity (HPLC, %) | Ntau dua lossis sib npaug li 98% |
| Cov mis mos molecular | C₃₀H₄₄N₁₂O₈ |
| Molecular Luj (Da) | 700.75 |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] | Azide- hloov kho cyclic RGD peptide; cyclic pentapeptide integrin- tsom rau peptide | Integrin targeting peptide, nyem chemistry conjugation, qog targeting, cell adhesion regulation, tshuaj xa | Cyclized pentapeptide nrog RGD core motif; D-phenylanine txhim kho kev ruaj ntseg enzymatic; lysine sab saw hloov nrog azide pawg; cyclic conformation ho txhim khu integrin binding affinity | C₂₇H₃₉N₁₁O₇ | 629.3 | ~629.7 | Trifluoroacetate (TFA) | 5 (cyclic pentapeptide) |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-CRD001 | Dawb hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot rau cia. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau shipping ntawm ambient kub. | ruaj khov rau 7 hnub ntawm 4 degree. TFA ntsev yog soluble hauv DMF, DMSO thiab dilute acetic acid. Azide pawg yog rhiab heev rau qhov kub thiab txias, muaj zog txo cov neeg ua haujlwm thiab cov tooj liab catalysts; Nws yooj yim rau decomposition thiab inactivation. Tsis txhob ua ke nrog cov tshuaj txo qis. | ruaj khov rau 2 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-CRD001 | Azide cyclic RGD peptide khi integrins nrog siab affinity rau qhov chaw- tshwj xeeb nias conjugation | Cyclic RGD azide peptide yog cyclized integrin -targeting peptide. Lub voj voog kev sib raug zoo kaw lub RGD motif hauv kev sib haum xeeb, ua rau ntau yam -fold ntau dua binding affinity rau integrins v ₃ thiab 5 ₁ piv nrog linear RGD peptides. D-Kev hloov kho phenylalanine ua rau muaj kev ruaj ntseg ntawm cov enzymes thiab ua rau lub sijhawm ua haujlwm vivo. Cov pab pawg azide ntawm lysine side chain enables site-kev sib txuas tshwj xeeb rau cov tshuaj, nanoparticles thiab proteins ntawm tooj liab-catalyzed azide-alkyne cycloaddition (CuAAC), rau kev txhim kho qog nqaij hlav- cov tshuaj tiv thaiv, tsom rau 1}cov tshuaj tiv thaiv kab mob sib xyaws thiab cov tshuaj tiv thaiv kab mob. | Tumor targeted therapy, click chemistry & bioconjugation, integrin biology, targeted drug delivery, biomaterial modification | Integrins v ₃ / 5 ₁; CuAAC cov tshuaj tiv thaiv; cell adhesion txoj kev |
Cim npe nrov: cas 2767993-86-0 cyclo[arg-gly-asp-d-phe-lys(azide)], China cas 2767993-86-0 cyclo[arg{11}}gly-asp-d-phe-lys(azide)] manufacturers, lwm tus neeg, Hoobkas
