Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov chaw muag khoom ntawm cys(npys)-tat (47-57), fam-labeled hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cys(npys)-tat (47-57), fam-labeled los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Kev piav qhia | Cys(Npys)-TAT (47-57), FAM-labeled yog bifunctional TAT cell- nkag mus rau peptide nrog cov kab ke C(Npys)YGRKKRRQRRRK(FAM)-NH₂{7}featuring ob qho tib si N cysteine thiab C-terminal FAM (5-carboxyfluorescein) daim ntawv lo. Cov peptide muaj peb lub luag haujlwm ua haujlwm: (1) N-terminal Npys-activated cysteine residue, qhov twg Npys (3-nitro-2-pyridinesulfenyl) yog thiol-cov pab pawg tshwj xeeb uas muaj cov tshuaj tiv thaiv tshwj xeeb (-SH) ntawm lwm cov molecule los ua ib qho asymmetric disulfide daim ntawv cog lus, ua kom qhov chaw- tshwj xeeb covalent conjugation ntawm TAT peptide rau lub hom phiaj cargo molecules (piv txwv li, cysteine -muaj proteins, peptides, antibody fragments me me, los yog thiolated); (2) nruab nrab TAT(47-57) core sequence (YGRKKRRQRRR), muab tau los ntawm residues 47-57 ntawm tus kab mob HIV-1 trans- activator ntawm transcription protein, classic cationic cell{40} nkag mus rau hauv cov ntaub so ntswg peptide thiab nkag mus rau hauv cov cell cell lub nucleus; (3) C-terminal FAM-labeled lysine residue, qhov twg FAM (5-carboxyfluorescein) yog xim ntsuab fluorescent dye nrog excitation wavelength ~ 492 nm thiab emission wavelength ~ 518 nm, ua kom lub sij hawm taug qab thiab kom muaj nuj nqis tsom xam ntawm peptide cellular uptake flow cytometry, thiab fluorescence spectroscopy. C-terminal amidation txhim kho cov metabolic stability ntawm peptide. Qhov kev tsim qauv no tso cai rau peptide kom yooj yim txuas rau ntau yam thiol-muaj cov khoom thauj khoom thauj los ntawm pawg Npys, thaum lub FAM fluorescent daim ntawv qhia ua rau lub sijhawm taug qab ntawm kev sib txuas ntawm cellular uptake thiab intracellular txoj hmoo, ua rau nws yog ib qho cuab yeej tseem ceeb rau kev kawm cell-peptide-mediated drug delivery and protein transduction. Nws yog dav siv nyob rau hauv intracellular tshuaj xa, protein transduction, cell imaging, thiab CPP mechanism kev tshawb fawb. |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| Cys(Npys)-TAT (47-57), FAM-labeled | FAM-labeled Npys- qhib TAT peptide; trifunctional conjugation-tracer penetrating peptide | Kev nkag mus ntawm tes, thiol site- tshwj xeeb conjugation, fluorescent tracing, trifunctional modified peptide | TAT peptide N-tau hloov kho nrog Npys- qhib cysteine thiab FAM fluorophore; muab cov cell nkag mus, qhov chaw- tshwj xeeb thiol conjugation thiab ntsuab fluorescent tracing | C₉₆H₁₃₈N₂₂O₂₀S₂ | 2079.01 | ~2080.6 | Trifluoroacetate (TFA) | 12 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-CNT001 | Yellow rau golden daj hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb, nyob rau hauv inert gas. Aliquot rau cia. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; tiv thaiv los ntawm oxygen thiab lub teeb thaum thauj khoom. | ruaj khov rau 7 hnub ntawm 4 degree. Soluble nyob rau hauv dilute acetic acid thiab acidic buffers. Npys nquag disulfide yog rhiab rau txo cov neeg ua haujlwm; FAM fluorescence yog rhiab rau lub teeb. Tsis txhob sib xyaw nrog thiol compounds thiab lub teeb muaj zog. | ruaj khov rau 2 xyoos ntawm -20 degree, qhuav, tiv thaiv los ntawm lub teeb thiab nyob rau hauv inert roj. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-CNT001 | Npys-activated + FAM-labeled TAT peptide nrog kev nkag / sib txuas / taug qab ua haujlwm | Cys(Npys)-TAT-FAM yog ib qho kev hloov pauv tsis zoo peptide. TAT ntu kho kom haum xeeb kom nkag mus rau ntawm tes tau zoo, Npys- qhib cysteine ua kom muaj chaw nyob - tshwj xeeb disulfide pauv nrog dawb thiol- muaj cov proteins / tshuaj tiv thaiv kab mob, thiab FAM muab cov tshuaj ntsuab fluorescent tracing. Nws ua rau ib qho - kauj ruam sib txuas thiab taug qab rau ADC kev txhim kho thiab kev hloov kho nanocarrier. | Antibody-tshuaj conjugate txoj kev loj hlob, nanocarrier functional modification, cell imaging & tracing, site-kev hloov kho tshuaj tshwj xeeb, kev xa tshuaj | Phospholipid bilayer; Npys thiol oriented conjugation; FAM Fluorescent Tracing |
Cim npe nrov: cys(npys)-tat (47-57), fam-labeled, China cys(npys)-tat (47-57), fam-labeled manufacturers, lwm tus neeg, Hoobkas
