Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov chaw muag khoom ntawm cas:1039726-31-2: dota-jr11 (satoreotide tetraxetan) hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas: 1039726-31-2: dota-jr11 (satoreotide tetraxetan) los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 1039726-31-2: DOTA-JR11 (Satoreotide tetraxetan) |
| Kev piav qhia | DOTA-JR11 yog ib qho kev xaiv zoo heev somatostatin receptor 2 (SSTR2) antagonist-raws li radionuclide conjugate peptide, covalently ua ke los ntawm antagonist peptide JR11 thiab macrocyclic chelator DOTA. JR11 moiety tshwj xeeb khi rau SSTR2 receptors ntawm cov qog cell, thaum lub DOTA moiety tuaj yeem ruaj khov chelate ntau yam xov tooj cua hlau nuclides xws li 68Ga thiab 177Lu rau PET imaging thiab tsom radionuclide kho mob neuroendocrine hlav. Piv nrog rau agonist-hom somatostatin peptides, nws cov cuab yeej antagonist tso cai rau kev khi rau ntau qhov chaw receptor yam tsis muaj kev cuam tshuam receptor internalization, txhim kho cov duab kos duab-rau- suab nrov piv thiab kho tau zoo. Nws yog cov cuab yeej tseem ceeb rau kev tshawb fawb txog kev kho mob qog noj ntshav nuclear. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Molecular Formula | C₇₄H₉₈ClN₁₉O₂₁S₂ |
| Molecular Luj (Da) | 1689.27 |
| Hom qauv | Cyclic peptide-chelator conjugate, ib khub ntawm intramolecular disulfide bonds, DOTA macrocyclic chelating pawg |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| DOTA-JR11 | Satoreotide tetraxetan; SSTR2 antagonist peptide | Kev xaiv ntau yam SSTR2 antagonist, radionuclide chelation, neuroendocrine qog imaging, tsom radionuclide kho | Cyclic peptide JR11 conjugated rau DOTA macrocyclic chelator ntawm tus linker; JR11 tsim ib lub voj voog ruaj khov ntawm ib daim ntawv cog lus intramolecular disulfide; DOTA chelates ntau radionuclides xws li ⁶⁸Ga thiab ¹⁷⁷Lu | C₇₄H₉₈ClN₁₉O₂₁S₂ | 1688.66 | 1689.27 | Dawb peptide / acetate | 8 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-DJR001 | hmoov dawb | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot rau cia. nruj me ntsis kom tsis txhob muaj zog txo cov neeg sawv cev los tiv thaiv disulfide daim ntawv cog lus cleavage. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; nkoj ntawm cov pob khov nab kuab pom zoo. | ruaj khov rau 7 hnub ntawm 4 degree. Dawb soluble hauv DMSO thiab DMF; me ntsis solubility nyob rau hauv physiological buffers, me ntsis txhim kho nyob rau hauv acidic tej yam kev mob. Disulfide daim ntawv cog lus tau nrawm nrawm thiab tsis ua haujlwm los ntawm cov neeg ua haujlwm txo qis. | ruaj khov rau 3 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-DJR001 | Kev xaiv ntau yam SSTR2 antagonist chelate peptide rau qog radionuclide imaging thiab kho | DOTA-JR11 yog ib qho kev xaiv zoo heev somatostatin receptor 2 (SSTR2) antagonist-raws li radionuclide conjugate peptide, covalently txuas los ntawm SSTR2 antagonist peptide JR11 thiab macrocyclic chelator DOTA. JR11 moiety tshwj xeeb khi rau SSTR2 receptors tau nthuav tawm heev ntawm cov qog cell nto nrog nanomolar affinity, thiab tsis induce receptor internalization, tso cai rau khi rau ntau qhov chaw receptor. Lub DOTA macrocycle tuaj yeem ruaj khov chelate ntau yam xov tooj cua hlau nuclides xws li ⁶⁸Ga, ¹⁷⁷Lu thiab ⁹⁰Y nyob rau hauv cov mob me me, txhawb nqa ob qho tib si PET duab thiab cov phiaj xwm kev kho mob radionuclide. Piv nrog rau agonist-hom somatostatin peptides, nws cov cuab yeej antagonist txhim kho cov teeb liab- rau- suab nrov piv ntawm qog cov duab thiab kho tau zoo. Nws yog cov cuab yeej tseem ceeb rau kev tshawb fawb theranostics ntawm SSTR- cov qog zoo. | Neuroendocrine qog kev tshawb fawb, kev tshawb fawb txog tshuaj nuclear kev tshawb fawb, tsom rau kev tshawb fawb radionuclide, kev tshawb fawb somatostatin receptor function, peptide-kev txhim kho tshuaj conjugate | Somatostatin receptor 2 (SSTR2); DOTA chelating pawg / radionuclide cab kuj |
Cim npe nrov: cas:1039726-31-2: dota-jr11 (satoreotide tetraxetan), Tuam Tshoj cas:1039726-31-2: dota-jr11 (satoreotide tetraxetan) manufacturers, lwm tus neeg, Hoobkas
