![CAS: 110880-55-2: [Sar⁹,Met(O₂)¹]-Substance P](/uploads/48442/cas-110880-55-2-sar-met-o-substance-paf1ff.jpg)
Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov chaw muag khoom ntawm cas:110880-55-2: [sar⁹,met(o₂)¹¹]-substance p hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas:110880-55-2: [sar⁹,met(o₂)¹¹]-substance p los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 110880-55-2: [Sar⁹,Met(O₂)¹]-Substance P |
| Kev piav qhia | Cov khoom no yog metabolically ruaj khov analog ntawm tej yam ntuj tso P, thiab ib tug heev xaiv thiab muaj zog agonist ntawm neurokinin 1 (NK1) receptors. Los ntawm qhov chaw-kev hloov kho tshwj xeeb ntawm protease- cov amino acid residues raug cuam tshuam, nws qhov kev tiv thaiv rau proteolytic degradation yog qhov ua tau zoo dua qub, nrog rau lub neej ntev dua hauv vivo ib nrab-lub neej ntau dua li cov khoom ntuj P. Nws muaj txiaj ntsig zoo ua rau cov kab mob hauv qab ntawm calcium signaling txoj kev kho los ntawm NK1 cov leeg mob sib cog lus, hauv kev ua haujlwm ntawm cov leeg nqaij, inducing cov leeg nqaij. teebmeem. Nws yog ib qho cuab yeej classic peptide hauv kev tshawb fawb neuropharmacology rau kev txheeb xyuas NK1 receptor muaj nuj nqi, kawm mob kis, neuroinflammation thiab du nqaij physiology. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Dawb peptide molecular mis | C₆₄H₉₉N₁₇O₁₆S |
| Dawb peptide molecular hnyav (Da) | 1394.64 |
| Hom qauv | Linear 11-mer peptide, site- hloov kho, C-terminal amidation, dawb peptide / acetate ntsev |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| [Sar⁹,Met(O₂)¹¹]-Substance P | Sar- tshuaj P sulfone analog | Kev xaiv NK1 receptor agonist siab, metabolically ruaj khov, mob kis, neuroinflamation | 11-mer tshuaj P analog nrog Gly9 hloov los ntawm sarcosine (Sar) thiab Met11 oxidized rau methionine sulfone, C-terminal amidation; Kev txhim kho peptidase ua haujlwm tau zoo thiab receptor selectivity | C₆₄H₉₉N₁₇O₁₆S | 1393.72 | 1394.64 | Dawb peptide / acetate | 11 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-SAR001 | hmoov dawb | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot kom tsis txhob rov qab khov-thaw mus. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; nkoj ntawm cov pob khov nab kuab pom zoo. | Nyob ruaj khov rau 14 hnub ntawm 4 degree. Dawb soluble hauv dej, dilute acetic acid thiab physiological buffers. Peptidase kuj tseem txhim kho zoo tom qab hloov kho; tshuaj stability yog superior rau haiv neeg P. | ruaj khov rau 3 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-SAR001 | Metabolically ruaj khov xaiv NK1 receptor agonist, cov cuab yeej rau kev tshawb fawb neuropharmacology | [Sar⁹,Met(O₂)¹¹]-Substance P yog ib qho metabolically ruaj khov analog ntawm haiv neeg P thiab ib qho kev xaiv, muaj zog agonist ntawm neurokinin 1 (NK1) receptors. Los ntawm kev hloov cov protease-glycine susceptible glycine ntawm txoj hauj lwm 9 nrog sarcosine thiab oxidizing methionine ntawm txoj hauj lwm 11 rau sulfone, nws tsis kam mus rau proteolytic degradation yog ho txhim kho, nrog ib tug ntev npaum li cas nyob rau hauv vivo ib nrab -lub neej tshaj li haiv neeg P, thaum pab txhawb NK1 receptorivation {9} thiab txo NK1 cov receptors. Raws li receptor khi, nws ua tau zoo activates downstream calcium signaling pathways, inducing smooth nqaij contraction, mob teeb liab transduction, neuroinflammatory mediator tso tawm thiab lwm yam kev lom. Nws yog ib qho cuab yeej classic peptide hauv neuropharmacology rau kev txheeb xyuas NK1 receptor muaj nuj nqi thiab kawm mob kis, neuroinflammation thiab du nqaij physiology. | Kev tshawb fawb Neuropharmacology, mob kis mechanism, kev tshawb fawb neuroinflammation, kev tshawb fawb ntawm cov leeg nqaij du, NK1 receptor functional identification | Neurokinin 1 receptor (NK1R); Calcium signaling txoj kev |
Cim npe nrov: cas:110880-55-2: [sar⁹,met(o₂)¹¹]-substance p, China cas:110880-55-2: [sar⁹,met(o₂)¹¹]-substance p manufacturers, lwm tus, Hoobkas
