Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 142569-99-1 rl-1620 hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 142569-99-1 rl-1620 los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 142569-99-1: IRL-1620 Nr |
| Kev piav qhia | IRL-1620 yog cov tshuaj peptide cov cuab yeej kho kom zoo raws li C-terminal fragment ntawm endothelin-1. Nws khi thiab ua kom cov endothelin B (ETB) receptors nrog kev xaiv siab, nrog rau kev sib raug zoo tsis tshua muaj rau ETA receptors thiab tsis muaj kev cuam tshuam loj heev. Tom qab ua kom ETB receptors ntawm vascular endothelial hlwb, nws induces tso tawm ntawm nitric oxide thiab prostacyclin, ua rau vasodilatory teebmeem; lub caij no, nws koom nrog cov txheej txheem physiological xws li neuroprotection, kev tswj lub raum cov ntshav khiav, thiab kev tswj hwm ntawm tes. Vim nws qhov kev xaiv meej meej, nws yog lub cuab yeej tseem ceeb peptide rau kev paub qhov txawv ntawm endothelin receptor subtype functions thiab kawm txog lub cev thiab lub luag haujlwm ntawm ETB receptors. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Theoretical molecular hnyav (Da) | ~ 2700 (raws li qhov tseeb hluavtaws batch) |
| Hom qauv | Hloov kho linear peptide, N-terminal succinylation, ntau qhov chaw amino acid hloov |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Hloov kho hom | Yam khoom |
| IRL-1620 Nws | IRL-1620; ETB xaiv agonist | ETB receptor heev xaiv agonism, Endothelin subtype tshawb fawb, Vasodilation, Neuroprotection, Lub raum ntshav khiav, cuab yeej peptide | Endothelin-1 C-terminal fragment backbone nrog qhov chaw hloov chaw thiab N-terminal hloov kho rau optimized subtype selectivity | Loj hloov peptide, raug rau cov batch MS | - | ~ 2700 (theoretical) | N-terminal succinylation + amino acid site hloov | ETB xaiv agonist cuab tam peptide |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-IRL001 | hmoov dawb | Khaws ntawm -20 degree, kaw, qhuav & tiv thaiv los ntawm lub teeb, aliquoted; zam rov qab khov-thaw cycles | ruaj khov rau 2 lub lis piam ntawm 2-8℃kaw & qhuav; ice pob shipping pom zoo | ruaj khov rau 7 hnub ntawm 4 degree; maj mam degraded los ntawm peptidases nyob rau hauv chav tsev kub ** Solubility ntawm dej, soluble nyob rau hauv nruab nrab los yog weakly alkaline tsis, txo solubility nyob rau hauv acidic tej yam kev mob **. Kev ruaj ntseg zoo dua li cov neeg endothelin tawg tom qab hloov kho | ruaj khov rau 2 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-IRL001 | Kev xaiv ETB receptor agonist heev uas tsis muaj ETA receptor kev ua, rau endothelin receptor subtype muaj nuj nqi sib txawv kev tshawb fawb | IRL-1620 tshwj xeeb khi G protein-coupled ETB receptors, activates downstream signaling pathways, thiab mediates ntau yam kab mob lom: ua rau vascular endothelial hlwb, induces nitric oxide synthase activation thiab nitric oxide tso tawm, tsim endothelium-dependent thiab vascular permeability; ua rau lub paj hlwb, txhawb nqa neurogenesis thiab txo qis ischemic paj hlwb raug mob, exerting neuroprotective teebmeem; tswj lub raum cov ntshav khiav thiab dej-sodium excretion, koom nrog rau kev ua haujlwm ntawm lub raum. Nws muaj kev sib raug zoo tsis muaj zog rau ETA receptors thiab tsis muaj qhov pom tseeb vasoconstrictive nyhuv, tuaj yeem paub qhov txawv ntawm lub cev thiab kev ua haujlwm ntawm ET receptor subtypes, thiab yog tus qauv kub cov cuab yeej peptide rau kev tshawb fawb endothelin. | Endothelin system kev tshawb fawb, Vascular function regulation, Neuroprotection research, Renal physiology, Hypertension mechanism, Receptor subtype validation | Endothelin B Receptor (ETBR); Nitric oxide / cGMP teeb liab txoj kev; Vasodilation thiab neuroprotective txoj kev |
Cim npe nrov: CAS 142569-99-1 rl-1620, Tuam Tshoj cas 142569-99-1 rl-1620 manufacturers, lwm tus, Hoobkas
