Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas: 820211-82-3: tiprelestat hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas: 820211-82-3: tiprelestat los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 820211-82-3: Tiprelestat |
| Kev piav qhia | Tiprelestat yog ib qho kev xaiv ntau heev neutrophil elastase (NE) inhibitor. Nws sib tw khi rau lub enzyme active hnab tshos thiab thaiv elastase degradation ntawm extracellular matrix thiab cov nqaijrog proteins, alleviating o -mediated ntaub so ntswg puas. Siv rau hauv kev tshawb fawb txog kev siv tshuaj thiab kev tsim tshuaj ntawm cov kab mob inflammatory xws li mob ntsws raug mob, COPD thiab cystic fibrosis. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Molecular Formula | C₂₅H₃₂N₄O₇S |
| Molecular Luj (Da) | 532.61 |
| Hom qauv | Peptidomimetic me me -molecule inhibitor nrog sulfonamide qauv |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Puv Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Hom qauv | Lub Hom Phiaj Xaiv |
| Tiprelestat | Tiprelestat; Elastase inhibitor; ONO-5046; CAS Nr .: 820211-82-3 | High NE selectivity, Los tiv thaiv -cov ntaub so ntswg puas, Kev mob ntsws mob ntsws, kev tshawb fawb COPD, Protease inhibitor, Anti- cov ntaub so ntswg tiv thaiv | Tripeptide mimetic qaum nrog kev hloov kho sulfonyl thiab aromatic hydrophobic sab chains | C₂₅H₃₂N₄O₇S | 532.2 | 532.61 | Peptidomimetic me -molecule inhibitor | High neutrophil elastase selectivity |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv -Lub Sijhawm Cia Cov Cai | Kua Stability | Khoom hmoov ruaj khov |
| SML{0}}TIP001 | hmoov dawb | Khaws ntawm -20 degree, kaw, qhuav & tiv thaiv los ntawm lub teeb, aliquoted; zam qhov kub thiab av noo | Khoom hmoov ruaj khov rau 3 xyoos ntawm 2-8℃kaw thiab qhuav; cov kev daws teeb meem npaj hauv DMSO | ruaj khov rau 1 lub hlis ntawm 4℃hauv qhov tsaus ntuj; ruaj khov rau 3 lub hlis ntawm -20℃hauv aliquots. ** Dej solubility tsis zoo, DMSO lossis acetonitrile xav tau rau solubilization **. Zoo heev ruaj khov; cov tshuaj tuaj yeem khaws cia luv -lub sij hawm ntawm chav tsev kub. Sensitive rau acid-base tej yam kev mob | ruaj khov rau ntau tshaj 3 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| SML{0}}TIP001 | Kev xaiv ntau neutrophil elastase inhibitor uas thaiv cov enzymatic degradation thiab alleviates inflammatory cov ntaub so ntswg puas. | Tiprelestat yog cov txheej txheem ua kom zoo dua peptidomimetic elastase inhibitor. Nws khi nrog siab affinity thiab siab xaiv rau lub active centre hnab tshos ntawm neutrophil elastase, thiab inhibits enzymatic degradation ntawm extracellular matrix proteins xws li elastin, collagen thiab fibronectin los ntawm kev sib tw thaiv substrate khi, yog li txo neutrophil-mediated ntaub so ntswg puas thiab edema. Cov molecule no muaj kev xaiv ntau dua rau neutrophil elastase ntau dua li lwm cov serine proteases, nrog qis qis - phiaj xwm tshwm sim. Hauv cov qauv xws li mob ntsws mob, mob ntsws obstructive pulmonary, cystic fibrosis thiab ischemia- raug mob reperfusion, nws tuaj yeem txo cov ntaub so ntswg puas tsuaj thiab txhim kho lub cev ua haujlwm. Nws ua hauj lwm raws li ib tug classic cuab yeej compound rau serine protease muaj nuj nqi kev tshawb fawb, inflammatory cov ntaub so ntswg puas mechanism tsom xam thiab tshiab protease inhibitor tshuaj txoj kev loj hlob. | Kev tshawb fawb mob ntsws mob ntsws, kev tshawb fawb COPD, Kev tshawb fawb cystic fibrosis, kev tshawb fawb serine protease, Kev tshawb fawb mob qog nqaij hlav, kev txhim kho Protease inhibitor | Neutrophil Elastase (NE); Kev sib tw inhibition ntawm serine protease active site; Extracellular matrix degradation blockade txoj kev |
Cim npe nrov: cas:820211-82-3:tiprelestat, Tuam Tshoj cas:820211-82-3:tiprelestat manufacturers, lwm tus neeg, Hoobkas
