Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas: 1075732-84-1: plecanatide acetate hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas: 1075732-84-1: plecanatide acetate los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 1075732-84-1: Plecanatide acetate |
| Kev piav qhia | Plecanatide yog ib qho kev ua kom zoo tshaj plaws hauv plab-targeted active peptide. Nws tshwj xeeb khi rau guanylate cyclase C receptors nyob rau sab luminal ntawm cov hnyuv me thiab cov kab mob colonic epithelial, activates lub intracellular cGMP signaling txoj kev, thiab ntxiv activates lub cystic fibrosis transmembrane conductance regulator (CFTR), txhawb lub secretion ntawm chloride ions, lub softening ntawm bicarbonate thiab dej. accelerating plab hnyuv transit. Nws cov qauv muaj ob khub ntawm disulfide bonds, ruaj khov nyob rau hauv acidic gastric kua txiv, thiab tuaj yeem ncav cuag txoj hnyuv kom ua rau muaj kev cuam tshuam. Siv rau hauv kev tshawb fawb txog kev siv tshuaj thiab kev tsim tshuaj ntawm kev mob plab idiopathic constipation, cem quav-predominant irritable plob tsis so tswj syndrome thiab lwm yam kab mob. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Dawb peptide molecular mis | C₆₅H₉₈N₁₆O₂₆S₄ |
| Dawb peptide molecular hnyav (Da) | 1615.81, siab dua rau daim ntawv acetate |
| Hom qauv | Cyclic hexadecapeptide, ob khub ntawm disulfide bonds, acetate ntsev |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Tus yam ntxwv | Daim ntawv ntsev |
| Plecanatide acetate hmoov | Plecanatide acetate; Plecanatide | GC-C receptor agonism, Cov kua dej hauv plab hnyuv nce qib, cem quav, mob plab hnyuv, Acid- ruaj khov, plab hnyuv peptide | Uroguanylin homologous hexadecapeptide qaum qaum nrog ob khub ntawm disulfide daim ntawv cog lus tuav nruj active conformation | Dawb peptide C₆₅H₉₈N₁₆O₂₆S₄ | 1614.59 | 1615.81 | Ob khub ntawm intramolecular disulfide bonds | Acetate |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-PLE001 | hmoov dawb | Khaws ntawm -20 degree, kaw, qhuav & tiv thaiv los ntawm lub teeb, nruj me ntsis txwv tsis pub txo tus neeg sawv cev, aliquoted; zam rov qab khov-thaw cycles | ruaj khov rau 1 lub hlis ntawm 2-8℃kaw & qhuav; ice pob shipping pom zoo | ruaj khov rau 14 hnub ntawm 4℃nyob rau hauv acidic tej yam kev mob; disulfide daim ntawv cog lus sai sai tawg thiab inactivate nyob rau hauv alkaline thiab txo ib puag ncig ** zoo solubility dej, dawb soluble nyob rau hauv acidic thiab nruab nrab buffers **. Disulfide bonds rhiab heev rau cov muaj zog txo cov neeg ua haujlwm thiab pH siab | ruaj khov rau 3 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-PLE001 | plab hnyuv - phiaj GC-C receptor agonist nrog cov kua qaub ruaj khov, txhawb nqa cov kua hauv plab, softens cov quav thiab txhim kho cem quav | Plecanatide ua raws li cov qauv thiab kev ua haujlwm ntawm endogenous uroguanylin, tshwj xeeb khi rau GC-C receptors ntawm lub apical membrane ntawm plab hnyuv epithelial hlwb, ua kom lub guanylate cyclase domain ntawm receptor, catalyzes hloov dua siab tshiab ntawm GTP rau cGMP, thiab elevates intracellular theem ob. Ntawm ib sab, cGMP activates CFTR chloride channels, txhawb kev tso tawm ntawm cov tshuaj chloride, bicarbonate thiab dej mus rau hauv txoj hnyuv lumen, nce cov dej hauv plab thiab cov quav mos; ntawm qhov tod tes, nws inhibits sodium -hydrogen exchangers kom txo sodium absorption, synergistically txhawb txoj hnyuv dej thiab ntsev secretion. Nws ob khub ntawm disulfide bonds endow lub molecule nrog siab structural stability, nws tsis yog yooj yim degraded nyob rau hauv acidic gastric kua txiv, thiab tuaj yeem ncav cuag cov hnyuv tom qab kev tswj hwm qhov ncauj kom ua rau muaj kev cuam tshuam hauv zos, nrog rau kev nqus me me thiab tsis tshua muaj kev phiv. | Chronic idiopathic constipation, cem quav-IBS predominant IBS, plab hnyuv dej- ntsev metabolism, Gastrointestinal physiology tshawb fawb, GC-C receptor muaj nuj nqi, Peptide tshuaj txhim kho | Guanylate Cyclase C Receptor (GC-C); cGMP/CFTR signaling txoj kev; Cov dej hauv plab -kev tso ntsev thiab kev thauj mus los |
Cim npe nrov: CAS: 1075732-84-1: plecanatide acetate, Tuam Tshoj cas: 1075732-84-1: plecanatide acetate manufacturers, lwm tus neeg, Hoobkas
