Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 848084-83-3 tigapotide hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 848084-83-3 tigapotide los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 848084-83-3: Tigapotide |
| Kev piav qhia | Tigapotide (kev loj hlob code PCK3145) yog mob qog noj ntshav prostate -targeted hluavtaws nonapeptide. Nws tshwj xeeb induces apoptosis ntawm prostate cancer hlwb, inhibits qog proliferation thiab metastasis, thiab yog siv nyob rau hauv castration- resistant prostate cancer, khoom qog apoptosis mechanism thiab antitumor peptide tshuaj txhim kho. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Theoretical molecular formula | C₅₄H₇₃N₁₃O₁₄ |
| Theoretical molecular hnyav (Da) | 1128.24 (raws li qhov tseeb hluavtaws batch) |
| Terminal kev hloov kho | Native dawb termini |
Khoom Description
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Tag Nrho Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | N-Terminal Hloov kho | C-Terminal Hloov kho | Qhov ntev (aa) |
| Tigapotide | Tigapotide; PCK3145; CAS 848084-83-3; Prostate cancer apoptotic peptide | Prostate cancer targeting, Pro-apoptotic nyhuv ntawm cov qog hlwb, proliferation thiab metastasis inhibition, Castration- tiv thaiv prostate cancer txoj kev tshawb fawb, Khoom qog nqaij hlav, Antitumor peptide | Asparagine-glutamine-tryptophan-phenylalanine-glutamine-leucine-methionine-asparagine-arginine | C₅₄H₇₃N₁₃O₁₄ (theoretical) | 1127.54 | 1128.24 | Dawb amine, tsis muaj kev hloov kho | Dawb carboxyl, tsis muaj kev hloov kho | 9 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv luv -Lub Sijhawm Cia Cia | Kua Stability | Khoom hmoov ruaj khov |
| PEB-TGP001 | hmoov dawb | Khaws ntawm -20 degree, kaw, qhuav & tiv thaiv los ntawm lub teeb, khaws cia hauv nitrogen hauv aliquots; tsis txhob rov qab khov-thaw cycles thiab muaj zog oxidizing tus neeg sawv cev | Khoom hmoov ruaj khov rau 2 xyoos ntawm 2-8℃kaw thiab qhuav; npaj cov tshuaj aqueous tshiab ua ntej siv | ruaj khov rau 48 h ntawm 4 degree; ruaj khov rau 2 lub lis piam ntawm -20℃hauv aliquots. Kev txwv dej solubility, me me ntawm DMSO lossis dilute acetic acid xav tau rau solubilization **. Methionine thiab tryptophan residues ua rau oxidative inactivation, cais tawm ntawm huab cua thiab lub teeb muaj zog | Ruaj khov rau 3 xyoos ntawm -20℃nyob rau hauv qhuav, tsaus nti & nitrogen cua |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov Cheeb Tsam Tshawb Fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-TGP001 | Prostate cancer-tsom nonapeptide uas tshwj xeeb induces qog cell apoptosis thiab inhibits proliferation thiab metastasis | Tigapotide yog cov tshuaj hluavtaws nonapeptide antitumor tshuaj ntsuam xyuas los ntawm prostate-cov proteins ntsig txog. Nws tshwj xeeb paub txog cov receptors saum npoo ntawm cov qog nqaij hlav qog nqaij hlav hauv prostate, nkag mus rau hauv cov hlwb kom qhib txoj hauv kev mitochondrial apoptosis, upregulates pro-apoptotic protein Bax expression, downregulates anti-apoptotic protein Bcl-2 level, thiab induces caspase cascade los ua qog cell apoptosis. Nws kuj inhibits qog cell invasion thiab metastasis muaj peev xwm thiab downregulates matrix metalloproteinase qhia. Cov molecule no nthuav tawm cov haujlwm tseem ceeb tawm tsam castration-resistant prostate cancer hlwb uas tsis muaj toxicity rau cov hlwb ib txwm, thiab tau nkag mus rau preclinical thiab ntxov soj ntsuam cov theem rau prostate cancer. Nws ua haujlwm raws li cov cuab yeej tseem ceeb rau cov qog nqaij hlav apoptosis kev tshawb fawb, kev txhim kho tshuaj tiv thaiv kab mob peptide, thiab kev tshawb fawb txog kev kho mob qog noj ntshav prostate. | Kev tshawb fawb txog kev mob qog nqaij hlav prostate, Castration- kev tshawb fawb txog kev mob qog nqaij hlav prostate, kev tshawb fawb qog apoptosis mechanism, kev tshawb fawb txog kev kho mob qog nqaij hlav, kev txhim kho Antitumor peptide, qog nqaij hlav metastasis inhibition kev tshawb fawb | Mitochondrial apoptosis txoj kev; Caspase cascade cov tshuaj tiv thaiv; Cov qog cell invasion thiab metastasis tswj txoj hauv kev |
Cim npe nrov: CAS 848084-83-3 tigapotide, Tuam Tshoj cas 848084-83-3 tigapotide manufacturers, lwm tus, Hoobkas
