Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 396091-79-5 pasireotide pamoate hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 396091-79-5 pasireotide pamoate los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 160212-}35-1:Nelipepimut-S |
| Kev piav qhia | Kuj tseem hu ua E75 peptide, nws yog siab -affinity HLA-A*0201 CTL epitope peptide muab tau los ntawm tib neeg epidermal growth factor receptor 2 (HER2/neu). Nws ua rau cov tshuaj tiv thaiv kab mob tshwj xeeb los tua HER2-zoo qog hlwb, thiab siv rau hauv cov tshuaj tiv thaiv qog nqaij hlav thiab kev tshawb fawb txog kev tiv thaiv kab mob ntawm lub mis, mob qog noj ntshav thiab lwm yam kab mob malignancies. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Cov mis mos molecular | C₅₀H₇₈N₁₀O₁₁ |
| Molecular Luj (Da) | 995.21 |
Khoom Description
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Tag Nrho Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Nruab nrab MW (Da) | N-Terminal Hloov kho | C-Terminal Hloov kho | Qhov ntev (aa) |
| Pasireotide pamoate | Pasireotide pamoate; SOM 230 pamoate; Cim npe; CAS Nr .: 396091-79-5 | Broad -spectrum SSTR agonist, High SSTR5 kev ua ub no, Cushing's kab mob tshawb fawb, Acromegaly kawm, Hormone secretion suppression, Ntev - ua yeeb yam sustained tso | Cyclohexapeptide core: Hydroxyproline-phenylglycine-D-tryptophan-lysine-O-benzyltyrosine-phenylalanine (caj qaum peptide bond cyclization, hydroxyproline side saw amino) conjugated nrog | C₈₁H₈₂N₁₀O₁₅ (1: 1 pamoate) | 1434.6 | 1435.58 | Rov qab cyclized, tsis muaj amine dawb | Cov pob txha cyclized, tsis muaj carboxyl dawb | 6 (cyclohexapeptide core nrog ntau yam tsis zoo ntawm cov amino acids thiab sab- kev hloov kho sawb) |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv -Lub Sijhawm Cia Cov Cai | Kua Stability | Khoom hmoov ruaj khov |
| PEB-PAS001 | hmoov dawb | Khaws ntawm -20 degree, nruj me ntsis tiv thaiv los ntawm lub teeb, kaw thiab qhuav, aliquoted; zam qhov kub thiab noo noo | Khoom hmoov ruaj khov rau 2 xyoos ntawm 2-8℃kaw thiab qhuav; cov kev daws teeb meem tau pom zoo kom npaj rau hauv DMSO | ruaj khov rau 72 h ntawm 4℃hauv qhov tsaus ntuj; ruaj khov rau 1 lub hlis ntawm -20℃hauv aliquots. ** Cov dej tsis zoo solubility, DMSO xav tau rau solubilization **. Pamoate ntsev muaj cov dej solubility qis dua li acetate. Hygroscopic, nruj nreem kaw rau kev tiv thaiv ya raws | ruaj khov rau 3 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-PAS001 | Broad -spectrum multi-subtype somatostatin receptor agonist nrog siab SSTR5 kev ua, muaj zog inhibits ACTH thiab kev loj hlob hormone secretion | Pasireotide yog ib tug rau - koom nrog cyclic peptide analog optimized raws li haiv neeg somatostatin qaum. Los ntawm kev qhia ntau yam tsis zoo ntawm cov amino acids thiab sab- kev hloov kho cov saw, nws ua tiav siab - kev sib raug zoo rau plaub hom somatostatin subtypes SSTR1, SSTR2, SSTR3 thiab SSTR5, tshwj xeeb tshaj yog tshaj 40-fold ntau dua SSTR5 kev ua octreotide. Nws muaj zog inhibits kev tso tawm ntawm ntau cov tshuaj hormones xws li adrenocorticotropic hormone (ACTH), kev loj hlob hormone, insulin thiab glucagon, thiab ib txhij inhibits qog cell proliferation thiab angiogenesis. Nws muaj qhov ua haujlwm dav dav thiab muaj zog dua, thiab tseem muaj txiaj ntsig zoo ntawm octreotide-cov qog nqaij hlav neuroendocrine. Nws ua haujlwm raws li cov cuab yeej tseem ceeb molecule rau kev tshawb fawb mechanism ntawm Cushing's kab mob, acromegaly, neuroendocrine qog thiab tshiab - tiam somatostatin tshuaj txhim kho. Daim ntawv pamoate ntsev feem ntau yog siv rau hauv kev tshawb fawb txog kev tso tawm ntev ntev. | Cushing's kab mob kev tshawb fawb, Acromegaly txoj kev tshawb fawb, Neuroendocrine qog kev tshawb fawb, Somatostatin txoj kev kawm, Hormone secretion regulation research, Long- ua yeeb yam sustained tso kev loj hlob | Somatostatin Receptors SSTR1/2/3/5; cAMP/PKA teeb liab txoj kev; Hormone secretion thiab qog proliferation txoj cai txoj kev |
Cim npe nrov: CAS 396091-79-5 pasireotide pamoate, Tuam Tshoj cas 396091-79-5 pasireotide pamoate manufacturers, lwm tus neeg, Hoobkas
