Cagrilintide CAS 1415456-99-3

Khoom Lub Npe Lus Askiv

Product Abbreviation / Alias

Function Tags (comma-sib cais)

Amino Acid Tag Nrho Lub Npe Sequence

Molecular Formula

Qhov hnyav Molecular (Da)

Qhov Nruab Nrab Molecular Luj (Da)

Terminal Hloov kho - N-terminus

Terminal Hloov kho - C-terminus

Qhov ntev (aa)

Cagrilintide

#Cagrilintide; CAS 1415456-99-3; pwm 833; Ntev-ua yeeb yam acylated amylin analog; Peptide poob phaus

Amylin receptor agonist, Ntev- ua yeeb yam tiv thaiv- rog peptide, qab los noj mov, kev tswj glycemic, Kev tshawb fawb kev rog rog, CTR / AMY receptor, Albumin- khi lipid hloov kho, Metabolic endocrine peptide

Eicosanedioic acid- -Glu-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala- Thr-Gln-Arg-Leu-Leu-Gln-Thr-Tyr-Arg-A sn-Asn-Ph-Val-His-Leu-Ser-Cys-Thr-Cy s-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr

C₁₉₄H₃₁₂N₅₄O₅₉S₂

4406.25

4409.01

N-terminal eicosanedioic acid lipid acylation (ntev fatty acid chain)

Dawb carboxyl, unmodified

37

Khoom Code

Qhov tshwm sim

Pom zoo Dissolution Protocol (los ntawm hnyav)

Solubility Reference

Tsis pom zoo Solvents

Ntev - Lub Sij Hawm Cia Cov Cai

Luv -Lub Sijhawm Cia Cov Cai

Kua Stability

Khoom hmoov ruaj khov

Muaj feem xyuam pH Range

PEB-CAG001

Dawb lyophilized hmoov

Dilute acetic acid, sterile dej rau kev txhaj tshuaj, nruab nrab PBS tsis; Lipid saw coj hydrophobicity, dilute acetic acid txhim kho solubility

Ntau dua lossis sib npaug li 8 mg / mL (0.1% aqueous acetic acid)

Tsis muaj dej ntshiab, alkanes, roj av ether organic solvents

-20 degree, kaw thiab lub teeb- pov thawj, aliquot kom tsis txhob rov khov-thaw

2 ~ 8 degree, siv nyob rau hauv 1 lub hlis, npaj tshiab thiab tsis muaj menyuam - lim ua ntej siv

ruaj khov rau 36 h ntawm 4 degree

ruaj khov rau 3 xyoos ntawm -20 degree

4.0~7.5

Khoom Code

Frontend Short Summary (rau cov npe tshawb nrhiav)

Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg

Cov cheeb tsam tshawb fawb (comma- cais)

Hom phiaj / Receptor

PEB-CAG001

Cagrilintide yog ib tug ntev - ua lipidated amylin analog, muaj zog agonist ntawm amylin AMY receptors thiab calcitonin CTR receptor, suppresses zaub mov noj, induces yuag poob thiab stabilizes postprandial ntshav qabzib, cov cuab yeej tseem ceeb peptide rau kev rog rog & metabolic syndrome kev tshawb fawb

Cagrilintide (AM833) yog ib qho hluavtaws stabilized amylin analog hloov nrog ntev - saw eicosanedioic acid. Muab ob npaug rau intramolecular disulfide bonds tuav cyclic conformation; N-terminal fatty acid chain enables siab -affinity serum albumin binding, drastic expansion in -vivo half-life. Nws tsis yog - xaiv muaj peev xwm qhib tau txhua yam amylin receptor subtypes AMY1 / AMY2 / AMY3 thiab calcitonin receptor CTR. Nws inhibits kev tshaib kev nqhis ntawm lub hauv nruab nrab lub paj hlwb, ncua lub plab khoob, txo cov calorie kom tsawg, inhibits glucagon secretion thiab smooths postprandial qabzib excursion. Hauv cov qauv preclinical, nws ua rau poob ceeb thawj, txo cov tshuaj insulin thiab tswj cov lipid metabolism. Kev siv dav hauv kev rog, hom 2 mob ntshav qab zib mellitus, metabolic syndrome, neural regulation of feeding behaviour, GPCR peptide pharmacology thiab ntev - ua peptide tus me nyuam mechanism kev tshawb fawb

Metabolic endocrinology, Kev rog rog -kev tshawb fawb poob, hom 2 mob ntshav qab zib hom, Kev tswj tus cwj pwm noj, Calcitonin receptor pharmacology, Ntev- ua yeeb yam peptide formulation, Insulin resistance mechanism, Metabolic syndrome tshuaj tshuaj

Amylin receptors AMY1R, AMY2R, AMY3R; Calcitonin receptor CTR (GPCR tsev neeg)

Khoom Code

Purity Detection Method

Molecular Weight Verification Method

Kev Tswj Xyuas Qhov Ntsuas

Impurity Control Standards

PEB-CAG001

HPLC High Performance Liquid Chromatography

ESI-MS Mass Spectrometry

Purity, dej ntsiab lus, Acetate, Hnyav hlau, Residual organic solvent, Disulfide daim ntawv cog lus kev ncaj ncees

Ib qho impurity Tsawg dua lossis sib npaug li 2%, Tag nrho cov impurities Tsawg dua lossis sib npaug li 5%

SKU Unique Code

Yam khoom Code

HPLC Purity

Ntim Specification

Lub Sijhawm Ua Haujlwm Ntau Lawm

Customizable

Optional Custom Modifications

Cov ntaub ntawv suav nrog

PEP-CAG001-98-1

PEB-CAG001

Ntau dua lossis sib npaug li 98%

1mg ib

5-10 hnub ua haujlwm

Yog lawm

Fluorescent labeling, Biotin labeling, Isotope labeling, Lipid chain length modification

CoA, HPLC spectrum, MS huab hwm coj spectrum, Disulfide daim ntawv qhia txog kev txheeb xyuas

PEP-CAG001-98-5

PEB-CAG001

Ntau dua lossis sib npaug li 98%

5mg ib

5-10 hnub ua haujlwm

Yog lawm

Fluorescent labeling, Biotin labeling, Isotope labeling, Lipid chain length modification

CoA, HPLC spectrum, MS huab hwm coj spectrum, Disulfide daim ntawv qhia txog kev txheeb xyuas

PEP-CAG001-95-1

PEB-CAG001

Ntau dua lossis sib npaug li 95%

1mg ib

5-10 hnub ua haujlwm

Yog lawm

Fluorescent labeling, Biotin labeling, Isotope labeling, Lipid chain length modification

CoA, HPLC spectrum, MS huab hwm coj spectrum, Disulfide daim ntawv qhia txog kev txheeb xyuas