Semaglutide CAS 910463-68-2

Khoom Lub Npe Lus Askiv

Product Abbreviation / Alias

Function Tags (comma-sib cais)

Amino Acid Tag Nrho Lub Npe Sequence

Molecular Formula

Qhov hnyav Molecular (Da)

Qhov Nruab Nrab Molecular Luj (Da)

Terminal Hloov kho - N-terminus

Terminal Hloov kho - C-terminus

Qhov ntev (aa)

Semaglutide

#Semaglutide; CAS 910463-}68-2; Ua haujlwm ntev GLP-1 peptide; GLP-1 receptor agonist

GLP-1 receptor agonist, Ntev- ua haujlwm hypoglycemic & yuag-tso, Lipidated hloov kho, Albumin khi, hom 2 mob ntshav qab zib, rog rog metabolism, qab los noj mov, Insulinotropic, Gastric emptying regulation

His-Aib-Glu-Gly-Thr-Ph-Thr-Ser-Asp-Val-Se r-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys( -Glu-octadecanedioic acid)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly{0}{3}

C₁₈₇H₂₉₁N₄₅O₅₉

4113.17

4114.58

Dawb amine, unmodified

Dawb carboxyl, unmodified

31

Khoom Code

Qhov tshwm sim

Pom zoo Dissolution Protocol (los ntawm hnyav)

Solubility Reference

Tsis pom zoo Solvents

Ntev - Lub Sij Hawm Cia Cov Cai

Luv -Lub Sijhawm Cia Cov Cai

Kua Stability

Khoom hmoov ruaj khov

Muaj feem xyuam pH Range

PEB-SEMA001

Dawb lyophilized hmoov

Dilute acetic acid, sterile dej rau kev txhaj tshuaj, nruab nrab PBS tsis; Lipid saw ua rau hydrophobicity, 0.1% glacial acetic acid txhim kho solubility

Ntau dua lossis sib npaug li 6 mg / mL (0.1% aqueous acetic acid)

Tsis muaj dej ntshiab, alkanes, roj av ether organic solvents

-20 degree, kaw thiab lub teeb- pov thawj, aliquot kom tsis txhob rov khov-thaw

2 ~ 8 degree, siv nyob rau hauv 1 lub hlis, npaj tshiab thiab tsis muaj menyuam - lim ntawm 0.22μm membrane

ruaj khov rau 48 h ntawm 4 degree

ruaj khov rau 3 xyoos ntawm -20 degree

4.0~7.5

Khoom Code

Frontend Short Summary (rau cov npe tshawb nrhiav)

Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg

Cov cheeb tsam tshawb fawb (comma- cais)

Hom phiaj / Receptor

PEB-SEMA001

Semaglutide yog ib tug ntev - ua lipidated GLP-1 analog nrog siab GLP-1 receptor affinity, muaj zog hypoglycemic thiab qab los noj mov-suppressing yuag poob los rau hom 2 mob ntshav qab zib & rog rog metabolism

Semaglutide yog 31-amino-acid ntev- ua peptide engineered los ntawm haiv neeg GLP-1, ob qho kev hloov kho tseem ceeb txhim kho metabolic stability: Ala8 hloov los ntawm Aib los tiv thaiv DPP4 degradation; Lys20 sab saw conjugated nrog -glutamate-octadecanedioic acid lipid tail, ua kom rov qab tau cov ntshav albumin khi thiab txuas ntxiv hauv -vivo ib nrab- lub neej dhau 7 hnub. Nws activates GLP-1 receptors nyob rau hauv pancreatic islets, central paj hlwb thiab peripheral cov ntaub so ntswg: 1. Glycemic tswj: Stimulates qabzib-dependent insulin secretion thiab suppresses glucagon tso tawm kom du postprandial qabzib; 2. Metabolic poob phaus: Central inhibition ntawm kev tshaib kev nqhis, qeeb plab hnyuv plab thiab txo calorie kom tsawg, txo qis visceral rog rog; 3. Cardiorenal tiv thaiv: Txhim kho endothelial muaj nuj nqi, txo albuminuria thiab tswj lipid profile. Kev siv dav hauv hom 2 mob ntshav qab zib mellitus, rog rog, NAFLD / NASH, kab mob cardiometabolic, GLP-1 GPCR pharmacology thiab kev tsim cov tshuaj peptide ntev.

Metabolic endocrinology, Diabetic pharmacology, Obesity weight-poob qauv, NAFLD/NASH research, Cardiometabolism, GPCR signaling pathway, Long-ua yeeb yam peptide, Kev tswj tus cwj pwm noj

GLP-1 Receptor GLP1R (Class BG protein-coupled receptor)

Khoom Code

Purity Detection Method

Molecular Weight Verification Method

Kev Tswj Xyuas Qhov Ntsuas

Impurity Control Standards

PEB-SEMA001

HPLC High Performance Liquid Chromatography

ESI-MS Mass Spectrometry

Purity, dej ntsiab lus, Acetate, Hnyav hlau, Residual hnyav, Lipid sab saw conjugation kev ncaj ncees

Ib qho impurity Tsawg dua lossis sib npaug li 2%, Tag nrho cov impurities Tsawg dua lossis sib npaug li 5%

SKU Unique Code

Yam khoom Code

HPLC Purity

Ntim Specification

Lub Sijhawm Ua Haujlwm Ntau Lawm

Customizable

Optional Custom Modifications

Cov ntaub ntawv suav nrog

PEP-SEMA001-98-1

PEB-SEMA001

Ntau dua lossis sib npaug li 98%

1mg ib

5-10 hnub ua haujlwm

Yog lawm

Biotin labeling, Fluorescent labeling, Isotope labeling, Lipid chain length modification

CoA, HPLC spectrum, MS huab hwm coj spectrum, Lipid hloov kho kev txheeb xyuas daim ntawv qhia

PEB-SEMA001-98-5

PEB-SEMA001

Ntau dua lossis sib npaug li 98%

5mg ib

5-10 hnub ua haujlwm

Yog lawm

Biotin labeling, Fluorescent labeling, Isotope labeling, Lipid chain length modification

CoA, HPLC spectrum, MS huab hwm coj spectrum, Lipid hloov kho kev txheeb xyuas daim ntawv qhia

PEP-SEMA001-95-1

PEB-SEMA001

Ntau dua lossis sib npaug li 95%

1mg ib

5-10 hnub ua haujlwm

Yog lawm

Biotin labeling, Fluorescent labeling, Isotope labeling, Lipid chain length modification

CoA, HPLC spectrum, MS huab hwm coj spectrum, Lipid hloov kho kev txheeb xyuas daim ntawv qhia