Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 524060-93-3 enavermotide hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 524060-93-3 enavermotide los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 524060-93-3: Enavermotide |
| Kev piav qhia | Enavermotide yog ib tug ntev - ua motilin receptor agonist. Amino acid hloov kho txhim kho metabolic stability. Nws txhawb nqa plab hnyuv du nqaij contraction thiab accelerates gastric emptying, thiab yog siv nyob rau hauv kev tshawb fawb mechanism ntawm gastroparesis, functional dyspepsia, gastrointestinal motility disorders thiab digestive txoj kev. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Theoretical molecular formula | C₁₁₇H₁₇₈N₃₄O₃₇ |
| Theoretical molecular hnyav (Da) | 2621.87 (raws li qhov tseeb hluavtaws batch) |
Khoom Description
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Tag Nrho Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Nruab nrab MW (Da) | N-Terminal Hloov kho | C-Terminal Hloov kho | Qhov ntev (aa) |
| Enavermotide | Enavermotide; Ntev - ua haujlwm motilin agonist; CAS Nr .: 524060-93-3 | Motilin receptor agonist, Gastroprokinetic nyhuv, Gastroparesis txoj kev tshawb fawb, Kev tshawb fawb ua haujlwm dyspepsia, Ntev - ua haujlwm metabolic stability, kev tswj lub plab zom mov | Phenylalanine-valine-proline-isoleucine-phenylalanine-threonine-tyrosine-glycine-glutamic acid-leucine-glutamine-arginine-methionine-glutamine-glutamic acid-lysine-glutamic acid-arginine-asparagine-lysine{19}}glycine-glutamine | C₁₁₇H₁₇₈N₃₄O₃₇ (theoretical) | 2620.31 (theoretical) | 2621.87 (theoretical) | Dawb amine, amino acid hloov pauv rau enzyme kuj | Dawb carboxyl | 22 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv -Lub Sijhawm Cia Cov Cai | Kua Stability | Khoom hmoov ruaj khov |
| PEB-ENA001 | hmoov dawb | Khaws ntawm -20 degree, kaw, qhuav & tiv thaiv los ntawm lub teeb, aliquoted; tsis txhob rov qab khov-thaw cycles thiab muaj zog oxidizing tus neeg sawv cev | Khoom hmoov ruaj khov rau 2 xyoos ntawm 2-8℃kaw thiab qhuav; npaj cov tshuaj aqueous tshiab ua ntej siv | ruaj khov rau 48 h ntawm 4 degree; ruaj khov rau 2 lub lis piam ntawm -20℃hauv aliquots. ** Dej solubility nruab nrab, dilute acetic acid los yog me me ntawm DMSO xav tau rau solubilization **. Methionine residue nquag oxidation. Ntev -chain peptide aqueous tov yooj yim degraded los ntawm peptidases nrog tsis zoo chav-kub stability | ruaj khov rau 3 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-ENA001 | Ntev - ua yeeb yam motilin receptor agonist uas txhawb nqa lub plab zom mov kom cov leeg mob thiab ua kom lub plab zom mov, siv rau hauv kev tshawb fawb txog kev mob plab | Enavermotide yog ib tug ntev - ua agonist optimized raws li haiv neeg motilin qaum. Qhov chaw tseem ceeb amino acid hloov pauv txhim kho enzymatic stability thiab receptor affinity. Nws tshwj xeeb khi rau motilin receptors ntawm cov nqaij ntshiv plab thiab cov hlab ntsha enteric, activates GPCR txoj hauv kev, tsub kom intracellular calcium concentration, induces rhythmic contraction ntawm gastrointestinal smooth nqaij, thiab accelerates plab hnyuv plab thiab hnyuv me. Nws cov metabolism hauv kev ruaj ntseg yog qhov zoo dua rau cov haiv neeg motilin nrog lub sijhawm ntev ntawm kev ua haujlwm thiab tsis muaj kev cuam tshuam hauv nruab nrab. Nws ua haujlwm raws li cov cuab yeej tshawb fawb txog kev mob plab hnyuv xws li gastroparesis, kev ua haujlwm dyspepsia thiab postoperative ileus, thiab tseem yog ib qho tseem ceeb ntawm cov hlau lead molecule rau kev tsim cov tshuaj tshiab gastroprokinetic. | Gastroparesis kev tshawb fawb, Kev tshawb fawb txog kev ua haujlwm dyspepsia, Kev tshawb fawb ntawm plab hnyuv motility, Kev tshawb fawb Postoperative ileus, Digestive physiology kawm, Gastroprokinetic tshuaj txhim kho | Motilin Receptor (MTLR); Gastrointestinal smooth nqaij contraction txoj kev; Calcium signaling txoj kev cai |
Cim npe nrov: CAS 524060-93-3 enavermotide, Tuam Tshoj cas 524060-93-3 enavermotide manufacturers, lwm tus, Hoobkas
