Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas: 118812-69-4: ularitide hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas: 118812-69-4: ularitide los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 118812-69-4: Ularitide |
| Kev piav qhia | Ularitide (tseem hu ua urodilatin) yog endogenous natriuretic peptide secreted los ntawm lub raum, lub raum isoform ntawm atrial natriuretic peptide (ANP) nrog ib qho ntxiv 4-amino acid N-terminal extension. Nws tshwj xeeb khi natriuretic peptide receptor A (NPR-A), elevates intracellular cGMP, thiab exerts physiological cuam tshuam nrog rau natriuresis / diuresis, vasodilation, ntshav siab txo thiab plawv load nyem. Siv rau hauv kev tshawb fawb mechanism ntawm mob plawv tsis ua hauj lwm, lub raum insufficiency, dej- ntsev metabolism teeb meem thiab mob plawv peptide tshuaj txoj kev loj hlob. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Molecular Formula | C₁₄₇H₂₃₄N₄₂O₄₄S₂ |
| Molecular Luj (Da) | 3428.86 |
| Terminal kev hloov kho | Native dawb termini, intramolecular disulfide cyclization |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Puv Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | N-Terminal Hloov kho | C-Terminal Hloov kho | Ntev (aa) |
| Ularitide | Ularitide; Urodilatin; Lub raum ANP isoform | Natriuresis & diuresis, Vasodilatory hypotension, mob plawv tsis ua hauj lwm kawm, Kev tswj lub raum ua haujlwm, NPR-A agonism, Dej- ntsev metabolism | Thr-Ala-Pro-Arg-Ser-Leu-Arg-Arg-Ser{-Ser-Cys-Ph-Gly-Gly-Arg-Met-As p-Arg-Ile-Gly-Ala-Gln-Ser-Gly{{23 }}Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr (Cys10-Cys25 disulfide txuas) | C₁₄₇H₂₃₄N₄₂O₄₄S₂ | 3427.66 | 3428.86 | Dawb amine, tsis muaj kev hloov kho | Dawb carboxyl, tsis muaj kev hloov kho | 32 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv -Lub Sijhawm Cia Cov Cai | Kua Stability | Khoom hmoov ruaj khov |
| PEB-ULA001 | hmoov dawb | Khaws ntawm -20 degree, kaw, qhuav & tiv thaiv los ntawm lub teeb, aliquoted. ** txwv tsis pub muaj zog los txo cov neeg ua hauj lwm ** | ruaj khov rau 1 lub hlis ntawm 2-8℃kaw & qhuav; npaj freshly ua ntej siv | ruaj khov rau 48h ntawm 4 degree; ruaj khov rau 2 lub lis piam ntawm -20℃hauv aliquots. ** Cov dej zoo solubility, dawb do soluble hauv dej thiab physiological tsis **. Disulfide choj yog rhiab heev rau cov muaj zog txo cov neeg ua haujlwm thiab ua rau cleavage. Native ntev peptide yooj yim degraded los ntawm endopeptidases | ruaj khov rau 2 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-ULA001 | Lub raum endogenous natriuretic peptide uas agonizes NPR-A rau natriuresis/diuresis thiab vasodilation kom txo tau lub plawv dhia | Ularitide yog 32-mer natriuretic hormone synthesized los ntawm lub raum distal tubular cells, lub raum- tshwj xeeb isoform ntawm ANP. Qhov ntxiv 4 N-terminal amino acids ua rau nws tiv taus qhov nruab nrab endopeptidase (NEP) ntau dua li kev ncig ANP, nrog rau lub sijhawm ntev ntawm vivo. Nws khi NPR-A receptors ntawm vascular du nqaij thiab lub raum khaws cov ducts, activates guanylate cyclase kom elevate cGMP, thiab kho ntau yam teebmeem: txhawb lub raum sodium / dej excretion, nce zis tso zis, txo cov ntshav ntim; dilates arterial thiab venous hlab ntsha, txo peripheral tsis kam thiab ntshav siab; inhibits lub renin -aldosterone system, txo lub plawv preload thiab afterload; kuj muaj me me los tiv thaiv -fibrotic thiab anti-inflammatory teebmeem. Nws txhim kho lub plawv thiab lub raum ua haujlwm tau zoo thiab txo edema hauv mob plawv tsis ua hauj lwm thiab lub raum raug mob qauv. Nws yog ib qho cuab yeej tseem ceeb rau natriuretic peptide system muaj nuj nqi kev tshawb fawb, lub plawv tsis ua hauj lwm mechanism tsom xam thiab kev kho mob plawv peptide tshuaj. | Kev tshawb fawb mob plawv tsis ua hauj lwm, Kev tshawb fawb lub raum ua haujlwm, Dej -Kev tshawb nrhiav ntsev metabolism, Cov qauv ntshav siab, kev txhim kho cov tshuaj mob plawv, Natriuretic peptide txoj hauv kev | Natriuretic Peptide Receptor A (NPR-A); cGMP kev taw qhia txoj hauv kev; Natriuresis / diuresis thiab vasodilation tswj txoj hauv kev |
Cim npe nrov: CAS: 118812-69-4:ularitide, Tuam Tshoj cas: 118812-69-4:ularitide manufacturers, lwm tus neeg, Hoobkas
