Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas: 1092457-65-2: dolcanatide hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas: 1092457-65-2: dolcanatide los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 1092457-65-2: Dolcanatide |
| Kev piav qhia | Dolcanatide yog ib tug tshiab - tiam structurally optimized GC -C receptor agonist peptide. Nws tshwj xeeb khi rau guanylate cyclase C receptors nyob rau sab luminal ntawm cov hnyuv me thiab colonic epithelial hlwb, elevates intracellular thib ob tub txib cGMP qib, thiab ntxiv activates lub cystic fibrosis transmembrane conductance regulator (CFTR), txhawb lub secretion ntawm chloride ions rau hauv cov txiv neej, cov dej hauv cov ntsiab lus, thiab cov tshuaj bicarbonate. softening quav thiab ua kom lub plab hnyuv. Nws ob khub ntawm disulfide bonds endow zoo heev acid stability. Tom qab kev tswj hwm qhov ncauj, nws tuaj yeem ncav cuag txoj hnyuv kom ua rau muaj kev cuam tshuam hauv zos. Siv rau hauv kev tshawb fawb mechanism ntawm kev mob plab idiopathic cem quav, cem quav -predominant irritable bowel syndrome thiab lwm yam kab mob, nrog rau kev txhim kho tshuaj peptide. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Dawb peptide molecular mis | C₇₈H₁₁₁N₂₁O₂₇S₄ |
| Dawb peptide molecular hnyav (Da) | ~1841.1 |
| Hom qauv | Cyclic hexadecapeptide, ob khub ntawm intramolecular disulfide bonds |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Nruab nrab MW (Da) | Tus yam ntxwv | Ntev (aa) |
| Dolcanatide | Dolcanatide; Qauv TSIS MUAJ: SP-304 | GC-C receptor agonism, Cov kua dej hauv plab hnyuv nce qib, cem quav ntev, Acid- ruaj khov, Txoj hnyuv hom phiaj, plab hnyuv peptide | Uroguanylin homologous caj qaum nrog ob khub ntawm disulfide daim ntawv cog lus tswj nruj active conformation | Dawb peptide C₇₈H₁₁₁N₂₁O₂₇S₄ | 1840.71 | 1841.1 | Ob khub ntawm intramolecular disulfide bonds | 16 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-DOL001 | hmoov dawb | Khaws ntawm -20 degree, kaw, qhuav & tiv thaiv los ntawm lub teeb, nruj me ntsis txwv tsis pub txo tus neeg sawv cev, aliquoted; zam rov qab khov-thaw cycles | ruaj khov rau 1 lub hlis ntawm 2-8℃kaw & qhuav; ice pob shipping pom zoo | ruaj khov rau 14 hnub ntawm 4℃nyob rau hauv acidic tej yam kev mob; disulfide daim ntawv cog lus sai sai tawg thiab tsis ua haujlwm nyob rau hauv alkaline thiab txo qhov chaw ib puag ncig ** Cov dej solubility nruab nrab, soluble hauv acidic thiab nruab nrab buffers **. Disulfide daim ntawv cog lus muaj kev nkag siab zoo rau cov muaj zog txo cov neeg ua haujlwm thiab pH siab | ruaj khov rau 3 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov Cheeb Tsam Tshawb Fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-DOL001 | Ntev - ua kua qaub- ruaj khov GC-C receptor agonist peptide uas txhawb nqa dej thiab ntsev tso tawm ntawm txoj hnyuv tsom, ua rau cov quav mos thiab txhim kho cem quav | Dolcanatide tshwj xeeb khi GC-C receptors ntawm lub apical daim nyias nyias ntawm plab hnyuv epithelial hlwb, qhib lub guanylate cyclase domain ntawm tus receptor, catalyzes hloov dua siab tshiab ntawm GTP rau cGMP, thiab elevates intracellular cGMP theem. Ntawm ib sab, cGMP activates CFTR chloride channels, txhawb kev tso tawm ntawm chloride, bicarbonate thiab dej rau hauv plab hnyuv lumen, nce cov dej hauv plab thiab cov quav mos; Ntawm qhov tod tes, nws inhibits sodium -hydrogen exchangers kom txo tau sodium reabsorption, synergistically txhawb txoj hnyuv dej thiab ntsev secretion thiab ua kom lub plab hnyuv. Nws cov txheej txheem optimized disulfide daim ntawv cog lus conformation yog ruaj khov nyob rau hauv acidic gastric kua txiv. Tom qab kev tswj hwm qhov ncauj, nws tuaj yeem ncav cuag txoj hnyuv loj kom ua rau muaj kev cuam tshuam hauv zos, nrog rau kev nqus me me thiab tsis tshua muaj kev phiv. | Chronic idiopathic constipation, cem quav-IBS predominant IBS, plab hnyuv dej- ntsev metabolism, Gastrointestinal physiology tshawb fawb, GC-C receptor muaj nuj nqi, Peptide tshuaj txhim kho | Guanylate Cyclase C Receptor (GC-C); cGMP/CFTR signaling txoj kev; Cov dej hauv plab -kev tso ntsev thiab kev thauj mus los |
Cim npe nrov: CAS: 1092457-65-2: dolcanatide, Tuam Tshoj cas: 1092457-65-2: dolcanatide manufacturers, lwm tus neeg, Hoobkas
