Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas: 227472-48-2: aminocandin hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas: 227472-48-2: aminocandin los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 227472-48-2: Aminocandin |
| Kev piav qhia | Aminocandin yog ib tug tshiab - tiam echinocandin antifungal cyclic lipopeptide. Nws tsis yog -kev sib tw inhibits fungal cell phab ntsa -1,3-glucan synthase, cuam tshuam fungal cell phab ntsa qauv, thiab ua kom muaj zog fungicidal kev tiv thaiv kab mob fungi xws li Candida thiab Aspergillus. Siv nyob rau hauv invasive fungal kab mob mechanism kev tshawb fawb, antifungal tshuaj txhim kho thiab fungal cell phab ntsa biology tshawb fawb. |
| Peptide Purity (HPLC, %) | 90%/95%/98% |
| Hom qauv | Echinocandin cyclic hexalipopeptide, amino hloov rau optimized dej solubility |
| Theoretical molecular hnyav (Da) | ~ 1150 (raws li qhov tseeb fermentation batch) |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Hom Cyclization | Hom qauv |
| Aminocandin | Aminocandin; Echinocandin antifungal peptide; CAS Nr .: 227472-48-2 | Antifungal kev ua haujlwm, -glucan synthesis inhibition, Echinocandin class, Invasive fungal kab mob, Candida / Aspergillus, Cyclic lipopeptide tshuaj tua kab mob | Cyclic hexapeptide core scaffold nrog polyhydroxy thiab amino hloov kho, sab saw conjugated nrog aromatic fatty acid | Loj cyclic lipopeptide, tsis muaj leej twg me me -molecule mis; raws li qhov tseeb batch MS | - | ~ 1150 (theoretical) | Peptide bond macrocyclization | Echinocandin cyclic lipopeptide |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv -Lub Sijhawm Cia Cov Cai | Kua Stability | Khoom hmoov ruaj khov |
| PEB-AMC001 | Dawb rau tawm -dawb amorphous hmoov | Khaws ntawm -20 degree, kaw, qhuav & tiv thaiv los ntawm lub teeb, aliquoted; zam kub, av noo thiab muaj zog acid / puag | Khoom hmoov ruaj khov rau 2 xyoos ntawm 2-8℃kaw thiab qhuav; cov kev daws teeb meem npaj hauv DMSO | ruaj khov rau 72 h ntawm 4℃nyob rau hauv cov dej tsis zoo. Yooj yim rau aggregation thiab degradation nyob rau hauv aqueous theem; ** tsis zoo aqueous daws stability **. ** Txwv dej solubility, DMSO lossis aqueous organic solvent xav tau rau solubilization **. Ester thiab amide bonds yooj yim hydrolyzed nyob rau hauv acid / puag. Aromatic sab chains nquag rau photooxidation | ruaj khov rau 2 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-AMC001 | Tshiab - tiam echinocandin antifungal cyclic lipopeptide uas inhibits -glucan synthase thiab muaj zog tua cov kab mob fungi | Aminocandin yog cov txheej txheem kho kom zoo echinocandin antifungal tus neeg sawv cev. Amino kev hloov kho tau qhia los ntawm lub hauv paus ntawm haiv neeg cyclic hexalipopeptide qaum pob txha los txhim kho cov dej solubility thiab cov tshuaj pharmacokinetic. Nws tshwj xeeb khi rau -1,3-glucan synthase complex ntawm fungal cell membrane, uas tsis yog-competitively inhibits lub catalytic kev ua si ntawm lub enzyme, blocks lub synthesis ntawm -1,3-glucan, lub core tivthaiv ntawm fungal cell phab ntsa, ua rau lub cell phab ntsa structural defects thiab osmotic cell tuag. Cov molecule no nthuav tawm muaj zog fungicidal kev ua haujlwm tawm tsam kev kho mob cov kab mob xws li Candida thiab Aspergillus, thiab tswj kev ua haujlwm zoo tiv thaiv azole-resistant fungal hom. Nws ua hauj lwm raws li cov cuab yeej tseem ceeb molecule rau invasive fungal kab mob mechanism kev tshawb fawb, antifungal tshuaj SAR optimization, thiab fungal cell phab ntsa synthesis txoj kev tsom xam. | Invasive fungal kab mob tshawb fawb, Tshuaj tiv thaiv kab mob kev loj hlob, Fungal cell phab ntsa biology, Candida / Aspergillus kawm, Echinocandin txoj kev kawm, Tshuaj- tiv thaiv fungi tshawb fawb | fungal -1,3-glucan synthase; Cell phab ntsa polysaccharide synthesis blockade txoj kev; Fungal osmotic lysis txoj kev |
Cim npe nrov: CAS: 227472-48-2: Aminocandin, Tuam Tshoj cas: 227472-48-2: Aminocandin manufacturers, lwm tus, Hoobkas
