Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas: 1402-82-0: amphomycin hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas: 1402-82-0: amphomycin los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 1402-82-0: Amphomycin |
| Kev piav qhia | Amphomycin yog tshuaj tua kab mob cyclic lipopeptide. Nws tshwj xeeb khi cov kab mob ntawm phab ntsa ntawm cov kab mob ua ntej Lipid II, thaiv cov txheej txheem peptidoglycan polymerization, inhibits Gram-cov kab mob zoo ntawm cov kab mob phab ntsa, thiab nthuav tawm cov kab mob muaj zog tiv thaiv kab mob xws li Staphylococcus aureus thiab Streptococcus. Siv rau hauv cov tshuaj -Resistant Gram-Kev tshawb nrhiav kab mob zoo, kev txhim kho tshuaj tua kab mob tshiab thiab kev tshawb fawb ntawm phab ntsa ntawm tes. |
| Peptide Purity (HPLC, %) | 90%/95%/98% |
| Theoretical molecular formula | C₅₉H₉₃N₁₃O₂₀ |
| Theoretical molecular hnyav (Da) | ~ 1272.45 (raws li qhov tseeb fermentation batch) |
| Hom qauv | Tsis yog -ribosomal acidic cyclic lipopeptide nrog unsaturated fatty acid sab saw hloov |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Hom Cyclization | Hom qauv |
| Amphomycin | Amphomycin; Cyclic lipopeptide tshuaj tua kab mob; CAS Nr .: 1402-82-0 | Anti-Gram- cov kab mob zoo, Cell phab ntsa synthesis inhibition, Lipid II targeting, Cyclic lipopeptide class, Natural tshuaj tua kab mob, Gram- kev tshawb fawb kab mob zoo | Macrocyclic peptide caj qaum cyclized ntawm lub taub hau- mus rau -tail amide daim ntawv cog lus, N-terminal conjugated nrog unsaturated ntev- saw fatty acid | C₅₉H₉₃N₁₃O₂₀ (theoretical) | 1271.66 | 1272.45 | Lub taub hau - mus rau -tail amide bond macrocyclization | Tsis yog -ribosomal acidic cyclic lipopeptide |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv -Lub Sijhawm Cia Cov Cai | Kua Stability | Khoom hmoov ruaj khov |
| PEB-AMP001 | Dawb rau daj ntseg daj amorphous hmoov | Khaws ntawm -20 degree, nruj me ntsis tiv thaiv los ntawm lub teeb, kaw thiab qhuav, aliquoted; zam kub thiab acid / puag | Khoom hmoov ruaj khov rau 2 xyoos ntawm 2-8℃kaw thiab qhuav; Cov kev daws teeb meem npaj hauv chloroform / methanol | ruaj khov rau 72 h ntawm 4℃nyob rau hauv cov dej tsis muaj dej & tsaus ntuj. Yooj yim rau nag lossis daus thiab inactivation hauv aqueous theem; ** aqueous tov tsis ruaj tsis khov **. ** Tsis tshua muaj dej solubility, chloroform, methanol lossis DMSO yuav tsum tau **. Unsaturated sab saw muaj oxidative degradation. Peptide daim ntawv cog lus yooj yim hydrolyzed nyob rau hauv acid / puag tej yam kev mob | ruaj khov rau 2 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-AMP001 | Ntuj acidic cyclic lipopeptide tshuaj tua kab mob uas lub hom phiaj Lipid II los thaiv cov phab ntsa cell synthesis thiab muaj zog inhibit Gram - cov kab mob zoo | Amphomycin yog ib yam tsis yog -ribosomal cyclic lipopeptide tshuaj tua kab mob uas tsim los ntawm Streptomyces fermentation. Cov molecule tsim ib qho qauv amphiphilic uas muaj lub nplhaib hydrophilic macrocyclic peptide thiab ib qho hydrophobic fatty acid sab saw. Nws tshwj xeeb khi cov phab ntsa ntawm tes ua ntej Lipid II nyob rau sab nraud ntawm cov kab mob cytoplasmic membrane, tsim ib qho chaw ruaj khov thiab sterically blocks substrate khi ntawm transglycosylase, inhibits peptidoglycan saw elongation thiab cell phab ntsa synthesis, thiab thaum kawg ua rau cov kab mob osmotic lysis thiab tuag. Cov molecule no nthuav tawm cov tshuaj tua kab mob muaj zog tiv thaiv ntau yam Gram- cov kab mob zoo xws li Staphylococcus aureus, Staphylococcus epidermidis thiab Streptococcus pyogenes, thiab tsis muaj tus ntoo khaub lig- tawm tsam nrog -lactam tshuaj tua kab mob. Nws ua haujlwm raws li cov cuab yeej cuab tam classic rau Gram- kev tshawb fawb txog kev kis tus kab mob zoo, kev txheeb xyuas cov phab ntsa ntawm tes, thiab cov tshuaj tua kab mob lipopeptide tshiab SAR optimization. | Gram- tshawb fawb cov kab mob zoo, Tshuaj- tiv thaiv kab mob kev tshawb fawb, Kab mob ntawm cov phab ntsa ntawm cov kab mob biology, Lipid II lub hom phiaj kev tshawb fawb, Kev tsim tshuaj tua kab mob ntuj, kev tshawb fawb tshuaj microbial | Bacterial cell phab ntsa precursor Lipid II; Peptidoglycan transglycosylase inhibition; Cell phab ntsa biosynthesis blockade txoj kev |
Cim npe nrov: CAS: 1402-82-0: amphomycin, Tuam Tshoj cas: 1402-82-0: amphomycin manufacturers, lwm tus, Hoobkas
