Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas: 239480-61-6: nbi-6024 hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas: 239480-61-6: nbi-6024 los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 239480-61-6: NBI-6024 NPE |
| Kev piav qhia | NBI-6024 yog ib qhov chaw- hloov kho proinsulin T cell epitope peptide. Nws txhawb kev tiv thaiv kab mob hauv cov tshuaj insulin tshwj xeeb autoreactive T hlwb, inhibits autoimmune attack ntawm pancreatic hlwb, thiab ncua kev loj hlob ntawm hom 1 mob ntshav qab zib. Siv rau hauv autoimmune ntshav qab zib, kev tiv thaiv kab mob tiv thaiv kab mob thiab kev tshawb fawb tshuaj tiv thaiv peptide. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Theoretical molecular hnyav | ~ 2.2 kDa |
| Hloov kho hom | Amino acid site hloov kho kom zoo dua MHC cov khoom sib txuas |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Tag Nrho Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Nruab nrab MW (Da) | Hloov kho Terminal | Qhov ntev (aa) |
| NIB-6024 | NBI-6024; Proinsulin kam rau ua peptide; Cov tshuaj tiv thaiv kab mob ntshav qab zib hom 1 peptide; CAS Nr .: 239480-61-6 | Immune tolerance induction, Autoimmunity inhibition, Hom 1 diabetes study, T cell epitope peptide, tshuaj peptide, Islet tiv thaiv | Proinsulin- tau muab hloov kho epitope peptide nrog qhov chaw hloov pauv tau zoo rau MHC chav kawm II khi | Loj polypeptide, tsis muaj meej me me -molecule mis; raws li qhov tseeb batch MS | - | ~ 2200 (theoretical) | Native dawb termini, tsis muaj tshuaj hloov kho | ~20 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv -Lub Sijhawm Cia Cov Cai | Kua Stability | Khoom hmoov ruaj khov |
| PEB-NBI001 | hmoov dawb | Khaws ntawm -20 degree, kaw, qhuav & tiv thaiv los ntawm lub teeb, aliquoted; zam rov qab khov-thaw cycles | Khoom hmoov ruaj khov rau 1 xyoos ntawm 2-8℃kaw thiab qhuav; npaj cov tshuaj aqueous hauv cov raj uas tsis muaj khi | ruaj khov rau 72 h ntawm 4℃nyob rau hauv tsis muaj menyuam; ruaj khov rau 1 lub hlis ntawm -20℃hauv aliquots. ** Cov dej zoo solubility, dawb do soluble hauv dej thiab physiological tsis **. Peptide nquag adsorb rau cov khoom siv yas; qis- khi centrifuge raj pom zoo. Rov qab khov-thaw ua rau epitope conformational hloov | ruaj khov rau 2 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-NBI001 | Hloov kho proinsulin T cell epitope peptide uas ua rau autoimmune kam rau ua thiab ncua kev mob ntshav qab zib hom 1. | NBI-6024 yog hloov kho peptide optimized raws li proinsulin B saw T cell epitope. Los ntawm cov kev hloov pauv tseem ceeb ntawm cov amino acid qhov chaw, nws hloov pauv txoj kev khi nrog MHC chav kawm II molecules, inducing autoreactive T hlwb mus rau kev ua siab ntev es tsis ua kom lub cev tiv thaiv kab mob. Nws tuaj yeem raug coj los thiab nthuav tawm los ntawm cov tshuaj tiv thaiv kab mob, ua rau CD4+ T cell anergy thiab tswj T cell expansion, inhibit tshwj xeeb autoimmune nres ntawm pancreatic hlwb, txo cov cell puas, thiab ncua qhov pib thiab kev loj hlob ntawm hom 1 mob ntshav qab zib. Cov peptide no ua haujlwm ua cov cuab yeej tseem ceeb rau hom 1 mob ntshav qab zib immunotherapy kev tshawb fawb, T cell tolerance mechanism tsom, peptide tshuaj tiv thaiv SAR optimization, thiab kev cuam tshuam kab mob autoimmune. | Kev tshawb nrhiav ntshav qab zib hom 1, Kev tshawb nrhiav kab mob autoimmune, Kev tiv thaiv kab mob tiv thaiv kab mob, T cell epitope tshawb fawb, Peptide tshuaj tiv thaiv, Islet biology tshawb fawb | MHC class II molecule -peptide complex; Autoreactive T cell kam rau ua txoj hauv kev; Pancreatic cell tiv thaiv kab mob |
Cim npe nrov: cas:239480-61-6:nbi-6024, Tuam Tshoj cas:239480-61-6:nbi-6024 manufacturers, lwm tus neeg, Hoobkas
