Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 12705-41-8 colistimethate sodium hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 12705-41-8 colistimethate sodium los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe CAS | 12705-41-8: Colistimethate sodium |
| Kev piav qhia | Colistimethate sodium yog cov tshuaj hloov kho tshuaj ntawm colistin (polymyxin E). Methanesulfonation neutralizes dawb amino pawg, txo qis nephrotoxicity ncaj qha thiab neurotoxicity thaum txhim kho dej solubility. Nws maj mam hydrolyzes nyob rau hauv vivo tso tawm active colistin, uas ua rau Gram -negative kab mob sab nrauv daim nyias nyias LPS thiab phospholipids, cuam tshuam cov membrane kev ncaj ncees thiab ua rau cov kab mob lysis. Nws nthuav tawm cov tshuaj tua kab mob muaj zog tiv thaiv ntau yam tshuaj -tiv taus Gram- cov kab mob tsis zoo xws li Pseudomonas aeruginosa thiab Acinetobacter baumannii. Siv rau hauv tshuaj-tiv taus Gram-kev tshawb fawb txog kev kis tus kab mob tsis zoo, kev tshuaj xyuas tshuaj tua kab mob pharmacodynamic thiab kev txhim kho tshuaj tua kab mob. |
| Purity (HPLC, %) | 90%/95%/98% |
| Qhov nruab nrab molecular hnyav (Da) | ~ 1750 (ntau -cov khoom sib xyaw) |
| Hom qauv | Cyclic lipopeptide prodrug, kev hloov kho methanesulfonated, sodium ntsev daim ntawv |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Hom Cyclization | Daim ntawv ntsev |
| Colistimethate sodium | Colistimethate; Colistin methanesulfonate; Polymyxin E methanesulfonate | Anti-MDR Gram-cov kab mob tsis zoo, Tsawg- tshuaj lom neeg cov tshuaj tiv thaiv, kev cuam tshuam ntawm daim nyias nyias, Pseudomonas/Acinetobacter kev ua, Cyclic lipopeptide tshuaj tua kab mob, Tus kab mob hnyav | Cyclic heptapeptide qaum + ceg tawv fatty acid, sab -chain amine methanesulfonated | Loj cyclic lipopeptide multi-cov khoom, raws li cov khoom siv MS | - | ~ 1750 (nruab nrab) | Lub taub hau - mus rau -tail amide bond macrocyclization | Sodium methanesulfonate |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv -Lub Sijhawm Cia Cov Cai | Kua Stability | Khoom hmoov ruaj khov |
| PEB-CMS001 | Dawb rau tawm -dawb amorphous hmoov | Khaws ntawm -20 degree, kaw, qhuav & tiv thaiv los ntawm lub teeb, aliquoted; zam qhov kub thiab av noo | ruaj khov rau 1 lub hlis ntawm 2-8℃kaw & qhuav; tolerable rau lub sij hawm luv luv chav tsev kub shipping | ruaj khov rau 24h ntawm 4 degree; nquag hydrolysis ntawm chav tsev kub; aqueous daws yuav tsum tau npaj freshly ua ntej siv.Zoo heev solubility dej, dawb do soluble nyob rau hauv dej thiab ib txwm saline Methanesulfonyl pawg maj mam hydrolyze nyob rau hauv aqueous tov kom tso active colistin; acid/base accelerates hydrolysis | ruaj khov rau 3 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-CMS001 | Tsawg-toxicity cyclic lipopeptide prodrug uas ua rau hauv vivo los tua MDR Gram- cov kab mob tsis zoo, nrog rau nephrotoxicity qis dua colistin sulfate | Colistimethate sodium yog ib qho classic polymyxin prodrug. Los ntawm methanesulfonating dawb amino pawg ntawm colistin sab chains, nws thaiv qhov ncaj qha nephrotoxicity thiab neurotoxicity los ntawm cov nqi zoo thaum txhim kho cov dej solubility. Tom qab nkag mus rau hauv lub cev, nws maj mam hydrolyzes nyob rau hauv cov ntshav thiab cov ntaub so ntswg, maj mam tso biologically active dawb colistin. Active colistin khi rau lipopolysaccharide (LPS) ntawm Gram-cov kab mob tsis zoo ntawm cov kab mob sab nrauv los ntawm kev sib cuam tshuam electrostatic, tshem tawm cov cations divalent ntawm daim nyias nyias, cuam tshuam cov txheej txheej membrane, ntxiv nkag mus rau hauv daim nyias nyias ua rau cytoplasmic membrane depolarization thiab cytoplasmic to, kawg ua rau cov kab mob cytoplasmic to. Cov molecule no nthuav tawm cov kab mob muaj zog tiv thaiv kev kho mob multidrug-tiv taus Gram- cov kab mob tsis zoo xws li Pseudomonas aeruginosa, Acinetobacter baumannii thiab carbapenem-resistant Enterobacteriaceae, thiab yog ib qho ntawm cov tshuaj tseem ceeb rau-cov kab mob kis tau tus kab mob Gramne {8}MDR's. Kev tshawb nrhiav kab mob kab mob, Cov qauv kab mob hnyav, Gram{11}}cov kab mob tsis zoo hauv biology, Tshuaj tua kab mob prodrug txhim kho, Pseudomonas/Acinetobacter research, Antibacterial | MDR kab mob kev tshawb fawb, Cov qauv kab mob hnyav, Gram-cov kab mob tsis zoo hauv biology, Kev txhim kho tshuaj tua kab mob, Pseudomonas/Acinetobacter research, Antibacterial mechanism research | Cov kab mob sab nrauv lipopolysaccharide (LPS) / phospholipids; Sab nrauv membrane permeability cuam tshuam txoj kev; Cov kab mob plasma membrane depolarization lysis txoj kev |
Cim npe nrov: CAS 12705-41-8 colistimethate sodium, Tuam Tshoj cas 12705-41-8 colistimethate sodium manufacturers, lwm tus neeg, Hoobkas
