Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov chaw muag khoom ntawm cas:1820563-84-5: nota-ae105 hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas: 1820563-84-5: nota-ae105 los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 1820563 -}84-5: NOTA-AE105 |
| Kev piav qhia | NOTA-AE105 yog radionuclide-conjugated imaging peptide targeting urokinase-type plasminogen activator receptor (uPAR), covalently ua ke los ntawm kev xaiv ntau heev uPAR antagonist peptide AE105 thiab macrocyclic chelator NOTA uPAR tau nthuav tawm ntau yam ntawm cov qog nqaij hlav qog nqaij hlav thiab qog nqaij hlav- txuam nrog macrophages, thiab muaj feem cuam tshuam nrog cov qog nqaij hlav, metastasis thiab cov tsos mob tsis zoo. AE105 tshwj xeeb khi rau uPAR nrog nanomolar affinity, thiab NOTA macrocycle tuaj yeem ruaj khov chelate positron nuclides xws li ⁶⁸Ga thiab ⁶⁴Cu nyob rau hauv cov mob me me, sib xws nrog PET / CT imaging rau tsis yog -invasive invasive invasion Levels and expression. Nws yog cov cuab yeej tseem ceeb peptide rau kev kuaj mob qog nqaij hlav, uPAR kev tshawb fawb txog kev ua haujlwm lom neeg thiab kev tsim kho cov tshuaj nuclear. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Cov mis mos molecular | C₆₃H₈₉N₁₇O₁₉S |
| Molecular Luj (Da) | 1432.55 |
| Hom qauv | Linear peptide-chelator conjugate, NOTA macrocyclic chelating pab pawg |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| NOTA-AE105 | uPAR- phiaj xwm chelate peptide | Kev xaiv ntau uPAR lub hom phiaj, radionuclide chelation, qog PET duab, ntxeem tau & kev ntsuam xyuas metastasis | Conjugate ntawm kev xaiv heev uPAR antagonist peptide AE105 thiab NOTA macrocyclic chelator; AE105 tshwj xeeb khi rau qog nto uPAR; NOTA chelates positron nuclides xws li ⁶⁸Ga thiab ⁶⁴Cu nyob rau hauv cov mob me. | C₆₃H₈₉N₁₇O₁₉S | 1431.62 | 1432.55 | Dawb peptide (chelated) | 13 (peptide ntu) |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-NAE001 | hmoov dawb | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot kom tsis txhob rov qab khov-thaw mus. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; nkoj ntawm cov pob khov nab kuab pom zoo. | ruaj khov rau 7 hnub ntawm 4 degree. Solubility: ~ 80 mg / mL hauv DMSO; dej solubility nruab nrab, pab los ntawm weakly acidic tsis. Tsis txhob sib cuag ntawm NOTA chelating pab pawg nrog dawb hlau ions. | ruaj khov rau 3 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-NAE001 | uPAR- tsom rau cov duab hluav taws xob hluav taws xob peptide rau qhov tsis yog -kev ntsuas kev cuam tshuam ntawm cov qog nqaij hlav thiab muaj peev xwm metastasis | NOTA-AE105 yog radionuclide-conjugated imaging peptide targeting urokinase-type plasminogen activator receptor (uPAR), covalently ua ke los ntawm kev xaiv ntau heev uPAR antagonist peptide AE105 thiab macrocyclic chelator NOTA uPAR tau nthuav tawm ntau yam ntawm cov qog nqaij hlav qog nqaij hlav thiab qog nqaij hlav- txuam nrog macrophages, thiab muaj feem cuam tshuam nrog cov qog nqaij hlav, metastasis, angiogenesis thiab cov tsos mob tsis zoo. AE105 tshwj xeeb khi rau uPAR nrog nanomolar affinity, thiab NOTA macrocycle tuaj yeem ruaj khov chelate positron nuclides xws li ⁶⁸Ga thiab ⁶⁴Cu nyob rau hauv cov mob me me, sib xws nrog PET / CT imaging rau tsis yog - ntxeem tau ntawm cov ntaub so ntswg dynamic ARludic qhia invasion / metastasis kev pheej hmoo thiab prognosis. Nws yog cov cuab yeej tseem ceeb peptide rau kev kuaj mob qog nqaij hlav, uPAR kev tshawb fawb txog kev ua haujlwm lom neeg thiab kev tsim kho cov tshuaj nuclear. | Kev tshawb nrhiav qog tsom rau kev kuaj mob, uPAR kev tshawb fawb txog kev ua haujlwm lom neeg, tshuaj nuclear PET duab, qog hlav thiab metastasis mechanism, kev txhim kho peptide tus neeg saib xyuas | Urokinase- hom plasminogen activator receptor (uPAR); NOTA chelating pawg / positron nuclide cab kuj |
Cim npe nrov: cas:1820563-84-5: nota-ae105, Tuam Tshoj cas:1820563-84-5: nota-ae105 manufacturers, lwm tus neeg, Hoobkas
