Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 1997361-85-9 semaglutide acetate hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 1997361-85-9 semaglutide acetate los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | Tom ntej: Semaglutide Acetate CAS 1997361-85-9 |
| Ib ntus | His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(C18 diacid--Glu-(AEEA)₂)-Glu-Phe-Ile-Ala-Trp-Le-Ar |
| Peb tsab ntawv ib ntus | H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(C18 diacid- -Glu-(AEEA)₂)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Cov mis mos molecular | C₁₈₉H₂₉₅N₄₅O₆₁ |
| Molecular Luj (Da) | 4173.69 |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Amino Acid Tag Nrho Lub Npe Sequence | Molecular Formula | Qhov hnyav Molecular (Da) | Qhov Nruab Nrab Molecular Luj (Da) | Terminal Hloov kho - N-terminus | Terminal Hloov kho - C-terminus | Qhov ntev (aa) |
| Semaglutide acetate hmoov | Semaglutide acetate; CAS 1997361-85-9 (dawb puag); Kev ua haujlwm ntev GLP-1 analog | GLP-1 receptor agonist, Ntev - ua haujlwm tiv thaiv - ntshav qab zib peptide, Kev tiv thaiv kev rog, kev noj qab haus huv, kev tshawb fawb txog metabolic, GPCR cov cuab yeej peptide | Histidine-2-aminoisobutyric acid-Glutamic acid-Glycine-Threonine-Phenylalanine-Threonine-Serine-Aspartic acid-Valine-Serine-Serine-Tyrosine-Leucine-Glutamic acid-Glycine-Glutamine-Alanine-Alanine{2{2} diacid- -Glutamic acid-(AEEA)₂]-Glutamic acid-Phenylalanine-Isoleucine-Alanine-Tryptophan-Leucine-Valine-Arginine-Glycine-Arginine-Glycine | C₁₈₉H₂₉₅N₄₅O₆₁ (monoacetate) | 4170.18 | 4173.69 | Dawb amine, unmodified | Dawb carboxyl, unmodified | 31 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv -Lub Sijhawm Cia Cov Cai | Kua Stability | Khoom hmoov ruaj khov |
| PEB-SEMA001 | Dawb hmoov | Khaws ntawm -20 degree, tiv thaiv lub teeb, kaw thiab qhuav, aliquoted; zam rov qab khov-thaw cycles thiab ya raws | Khoom hmoov ruaj khov rau 2 xyoos kaw thiab qhuav ntawm 2-8 degree; npaj aqueous daws freshly ua ntej siv, aliquots ruaj khov rau 1 lub hlis ntawm -20 degree; 0.1% BSA raug pom zoo kom ncua kev ruaj ntseg | ruaj khov rau 72 h ntawm 4 degree; zam rov qab khov -thaw cycles | ruaj khov rau 3 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Hom phiaj / Receptor |
| PEB-SEMA001 | Ntev- ua yeeb yam xaiv GLP-1 receptor agonist; Glucose-dependent glycemic tswj, qab los noj mov, kev noj zaub mov qeeb qeeb, poob phaus thiab cov txiaj ntsig cardiometabolic | Semaglutide acetate yog qhov ntev - ua yeeb yam hloov pauv ntawm tib neeg glucagon-zoo li peptide-1 (GLP-1). Nws qhia tau hais tias muaj kev xaiv siab rau GLP-1 receptors uas tsis muaj kev cuam tshuam tseem ceeb rau GIP lossis glucagon receptors. Kev hloov pauv Aib ntawm txoj haujlwm 2 muab qhov zoo tshaj plaws tiv thaiv rau dipeptidyl peptidase-4 (DPP-4) proteolysis. A C18 fatty diacid sab saw yog covalently conjugated rau ε-amino pab pawg ntawm Lys20, ua rau reversible serum albumin binding thiab ntev heev nyob rau hauv vivo ib nrab-lub neej, muab cov qauv hauv paus rau kev tsim qauv ntev. Nws txhawb kev tsim cov tshuaj insulin thiab txo qis glucagon tso tawm hauv cov piam thaj-dependant kom ruaj khov glycemic hloov pauv. Nws kuj tseem ncua lub plab zom mov thiab txo qhov qab los noj mov hauv nruab nrab kom txo tau cov zaub mov kom tsawg thiab ua kom poob phaus. Tsis tas li ntawd, nws nthuav tawm cov dej num suav nrog kev txhim kho lipid profile, txo qis vascular o thiab ameliorated hepatic lipid metabolism kom qeeb MASLD kev loj hlob. Nws yog dav siv rau kev tshawb fawb pharmacological thiab tshiab peptide tshuaj txhim kho lub hom phiaj hom 2 mob ntshav qab zib, rog rog, metabolic txuam nrog kab mob siab thiab kev tiv thaiv kab mob plawv. | Diabetes pharmacology tshawb fawb, Kev rog rog thiab kev tshawb nrhiav kab mob metabolic, Tshuaj tiv thaiv - mob ntshav qab zib peptide tshuaj txhim kho, MASLD kev tshawb fawb, Kev tshawb fawb tshuaj mob plawv, GPCR qhia txoj kev tshawb fawb | Glucagon-zoo li peptide-1 receptor (GLP-1R); cAMP/PKA teeb liab txoj kev |
Cim npe nrov: CAS 1997361-85-9 semaglutide acetate, Tuam Tshoj cas 1997361-85-9 semaglutide acetate manufacturers, lwm tus neeg, Hoobkas
