Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas: 2855063-75-9: talfirastide acetate hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas: 2855063-75-9: talfirastide acetate los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 2855063-75-9: Talfiastide acetate |
| Kev piav qhia | Talfirastide yog ib qho kev xaiv peptide inhibitor ntawm tib neeg neutrophil elastase (HNE). Nws sib tw khi rau lub catalytic active centre ntawm NE, thaiv nws degradation ntawm extracellular matrix thiab hauv qab daus daim nyias nyias nyob rau hauv lub ntsws thiab vascular cov ntaub so ntswg, thiab alleviates inflammatory cascade puas thiab cov ntaub so ntswg remodeling puas los ntawm ntau tshaj neutrophil ua kom. Nws cov qauv kev hloov kho cyclic zoo heev txhim kho metabolic stability thiab enzyme binding affinity. Nyob rau hauv cov qauv ntawm mob ntsws raug mob, mob obstructive pulmonary kab mob thiab idiopathic pulmonary fibrosis, nws muaj peev xwm txo tau pulmonary inflammatory infiltration thiab ncua kev loj hlob ntawm cov ntaub so ntswg fibrosis. Nws yog cov cuab yeej tseem ceeb peptide rau kev tshawb fawb txog kev raug mob inflammatory thiab protease inhibitor tshuaj txhim kho. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Dawb puag molecular mis | C₄₈H₆₈N₁₂O₁₂ |
| Dawb puag molecular hnyav (Da) | 1005.13, siab dua rau daim ntawv acetate |
| Hom qauv | Cyclic functional peptide nrog nruj cyclization hloov kho, acetate ntsev |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| Talfirastide acetate | Talfirastide acetate; cyclic HNE inhibitor | Neutrophil elastase inhibitor, tiv thaiv - mob & tiv thaiv -fibrotic, kev tiv thaiv lub ntsws, protease inhibition | Rigid cyclic peptide qaum, optimized rau active hnab tshos khi ntawm unnatural amino acid hloov, xaiv heev inhibits human neutrophil elastase (HNE); acetate ho txhim kho dej solubility | Dawb peptide: C₄₈H₆₈N₁₂O₁₂ | 1004.51 | 1005.13 | Acetate | Cyclic nonapeptide qaum |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-TAL001 | hmoov dawb | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot kom tsis txhob rov qab khov-thaw mus. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau luv - lub sij hawm shipping ntawm ambient kub. | ruaj khov rau 7 hnub ntawm 4 degree. Dawb soluble hauv DMSO; dej solubility nruab nrab, pab los ntawm dilute acetic acid los yog acidic tsis. Cyclic peptide qauv muab tshuaj lom neeg ruaj khov zoo heev. | ruaj khov rau 3 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-TAL001 | Highly selective cyclic HNE inhibitor alleviates inflammatory kev raug mob thiab ncua cov nqaij mos fibrosis | Talfirastide yog ib qho kev xaiv peptide inhibitor ntawm tib neeg neutrophil elastase (HNE). Nws sib tw khi rau lub catalytic active centre ntawm NE, thaiv nws degradation ntawm extracellular matrix thiab hauv qab daus daim nyias nyias nyob rau hauv lub ntsws thiab vascular cov ntaub so ntswg, thiab alleviates inflammatory cascade puas thiab cov ntaub so ntswg remodeling puas los ntawm ntau tshaj neutrophil ua kom. Nws cov qauv kev hloov kho cyclic zoo heev txhim kho metabolic stability thiab enzyme binding affinity. Nyob rau hauv cov qauv ntawm mob ntsws raug mob, mob obstructive pulmonary kab mob thiab idiopathic pulmonary fibrosis, nws muaj peev xwm txo tau pulmonary inflammatory infiltration thiab ncua kev loj hlob ntawm cov ntaub so ntswg fibrosis. Nws yog cov cuab yeej tseem ceeb peptide rau kev tshawb fawb txog kev raug mob inflammatory thiab protease inhibitor tshuaj txhim kho. | Mob ntsws raug mob / ARDS tshawb fawb, idiopathic pulmonary fibrosis kawm, kev tshawb fawb COPD, inflammatory raug mob mechanism kawm, protease inhibitor tshuaj tsim kho | Human neutrophil elastase (HNE); Extracellular matrix degradation thiab inflammatory cascade txoj kev |
Cim npe nrov: CAS: 2855063-75-9: talfirastide acetate, Tuam Tshoj cas: 2855063-75-9: talfirastide acetate manufacturers, lwm tus neeg, Hoobkas
