Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas: 1647120-04-4: velmupressin acetate hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas: 1647120-04-4: velmupressin acetate los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 1647120-04-4: Velmupressin acetate CAS TSIS TAU |
| Kev piav qhia | Velmupressin yog ib qho tshiab - tiam neeg xaiv vasopressin V2 receptor agonist. Multi- site amino acid hloov kho tau txhim kho receptor subtype selectivity. Nws tshwj xeeb ua rau lub raum khaws cov duct V2 receptors, txhawb nqa aquaporin membrane translocation kom siv cov nyhuv antidiuretic. Nws muaj kev sib raug zoo tsis tshua muaj rau V1a receptors, nrog rau vasoconstriction tsis muaj zog thiab cov kev mob tshwm sim ntau dua li cov uas tsis yog - xaiv vasopressin. Siv rau hauv kev tshawb fawb mechanism ntawm cov kab mob xws li ntshav qab zib insipidus, nocturia thiab dej- ntsev metabolism, nrog rau kev txhim kho tshuaj vasopressin tshiab. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Hom qauv | Disulfide-bridged hloov kho nonapeptide analog, acetate ntsev |
| Theoretical molecular hnyav (Da) | ~ 1100 (peptide dawb), me ntsis siab dua rau acetate |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Hom Cyclization | Daim ntawv ntsev |
| Velmupressin acetate hmoov | Velmupressin acetate; Muaj kev xaiv V2 agonist peptide; Novel antidiuretic peptide | High V2 receptor selectivity, Antidiuretic nyhuv, Ntshav qab zib insipidus kawm, Dej- ntsev metabolism, kev tshawb fawb Nocturia, Vasopressin analog | Hloov kho vasopressin cyclic peptide qaum, qhov chaw- optimized rau receptor selectivity, disulfide cyclized | Loj hloov peptide, tsis muaj meej me me -molecule mis; raws li qhov tseeb batch MS | - | ~ 1100 (peptide dawb) | Intramolecular disulfide choj | Acetate |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv -Lub Sijhawm Cia Cov Cai | Khoom hmoov ruaj khov | |
| PEB-VMP001 | hmoov dawb | Khaws ntawm -20 degree, nruj me ntsis tiv thaiv los ntawm lub teeb, kaw thiab qhuav, aliquoted. ** txwv tsis pub muaj zog los txo cov neeg ua hauj lwm ** | ruaj khov rau 2 xyoos ntawm 2-8℃kaw & qhuav; npaj cov tshuaj aqueous tshiab ua ntej siv | ruaj khov rau 72 h ntawm 4 degree; ruaj khov rau 1 lub hlis ntawm -20℃hauv aliquots. ** Cov dej zoo solubility, dawb do soluble hauv dej thiab physiological tsis **. Disulfide choj rhiab heev rau cov muaj zog txo cov neeg ua haujlwm thiab nquag cleavage. Cov kev hloov kho ntawm qhov chaw tseem ceeb txhim kho enzymatic tsis kam | ruaj khov rau 3 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-VMP001 | Muaj kev xaiv V2 receptor agonist vasopressin analog uas tshwj xeeb tswj lub raum dej reabsorption nrog muaj zog antidiuretic kev ua haujlwm thiab tsis tshua muaj kev phiv. | Velmupressin yog ib qho tshiab - tiam arginine vasopressin analog optimized los ntawm ntau - hloov chaw. Amino acid site optimization ua tau zoo txhim kho kev xaiv rau V2 receptors thiab tsis tshua muaj affinity rau cov hlab plawv-txog receptors xws li V1a, yog li thaum exerting muaj zog antidiuretic nyhuv, peripheral cov kev phiv xws li ntshav siab nce thiab vasoconstriction yog ho tsis muaj zog dua li uas tsis yog -selective vaso. Nws tshwj xeeb khi rau V2 receptors ntawm lub raum khaws cov hlab ntsha tseem ceeb hauv lub raum, ua kom lub cev cAMP / PKA teeb liab txoj hauv kev, txhawb nqa aquaporin 2 (AQP2) hloov mus rau cov cell membrane, txhim kho cov dej dawb rov qab los rau hauv lub raum, ua kom cov zis thiab txo cov zis tso zis. Piv nrog rau classic desmopressin, nws muaj ntau dua receptor selectivity, zoo dua metabolic stability thiab tswj tau ntau lub sij hawm ntawm kev ua. Cov molecule no ua haujlwm raws li cov cuab yeej tshawb fawb txog cov kab mob xws li hauv nruab nrab ntshav qab zib insipidus, nocturia thiab dej - ntsev metabolism, thiab tseem yog ib qho tseem ceeb ntawm cov hlau lead molecule rau kev txhim kho cov tshuaj vasopressin tshiab. | Kev tshawb nrhiav ntshav qab zib insipidus, Dej-kev tshawb nrhiav ntsev metabolism, lub raum physiology, Nocturia qauv kev tshawb fawb, Vasopressin receptor muaj nuj nqi, Tshuaj kho mob plawv | Arginine Vasopressin V2 Receptor; cAMP/PKA teeb liab txoj kev; Lub raum aquaporin tswj txoj kev |
Cim npe nrov: CAS: 1647120-04-4: velmupressin acetate, Tuam Tshoj cas: 1647120-04-4: velmupressin acetate manufacturers, lwm tus neeg, Hoobkas
