Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas: 139570-93-7: zoptarelin doxorubicin hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale zoo cas: 139570-93-7: zoptarelin doxorubicin los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 139570-93-7: Zoptarelin doxorubicin |
| Kev piav qhia | Zoptarelin doxorubicin yog peptide -drug conjugate (PDC). Nws siv lub siab -affinity LHRH agonist peptide raws li lub hom phiaj tus neeg nqa khoom kom xa cov tshuaj cytotoxic doxorubicin rau cov qog hlwb uas muaj LHRH receptor siab qhia (prostate cancer, cancer mis, endometrial cancer), thiab tso tawm cov tshuaj nyob rau hauv cov qog ua kom tua cov nyhuv, txo cov kab mob toxicosis ntawm cov tshuaj. Siv rau hauv cov phiaj xwm kev tshawb fawb antitumor, peptide tshuaj conjugation technology, thiab kev tsim cov qog nqaij hlav tsom rau kev tshawb fawb. |
| Peptide Purity (HPLC, %) | 90%/95%/98% |
| Theoretical molecular hnyav (Da) | ~ 1700 (raws li qhov tseeb batch) |
| Hom qauv | Peptide-me me molecule conjugate, cleavable linker |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Hom qauv | Target Receptor |
| Zoptarelin doxorubicin | Zoptarelin doxorubicin; LHRH-targeted doxorubicin conjugate; UA-152 | Targeted antitumor, Peptide -tshuaj conjugate, LHRH receptor targeting, Prostate cancer research, Txo cov tshuaj toxicity, Reproductive system hlav | LHRH agonist decapeptide + cleavable linker + doxorubicin anthracycline pharmacophore | Loj conjugate, tsis meej me me -molecule mis; raws li qhov tseeb batch MS | - | ~ 1700 (theoretical) | Peptide-me me molecule conjugate | LHRH receptor (GnRHR) |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv -Lub Sijhawm Cia Cov Cai | Kua Stability | Khoom hmoov ruaj khov |
| PEB-ZOP001 | Txiv kab ntxwv - liab hmoov | Khaws ntawm -20 degree, nruj me ntsis tiv thaiv los ntawm lub teeb, kaw thiab qhuav, aliquoted. ** Cytotoxic, kov nrog kev tiv thaiv ** | Khoom hmoov ruaj khov rau 1 xyoos ntawm 2-8℃kaw hauv qhov tsaus ntuj; npaj cov tshuaj aqueous tshiab ua ntej siv | ruaj khov rau 48 h ntawm 4℃hauv qhov tsaus ntuj; ruaj khov rau 2 lub lis piam ntawm -20℃hauv aliquots. ** Dej solubility nruab nrab, dawb soluble nyob rau hauv aqueous organic solvents thiab acidic buffers **. Cov qauv Anthracycline yog rhiab heev rau lub teeb thiab nquag oxidative degradation. Linker yooj yim cleaved nyob rau hauv acid / puag thiab enzymatic tej yam kev mob los tso tshuaj | ruaj khov rau 2 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-ZOP001 | LHRH-targeted peptide-cov tshuaj conjugate uas xa cov doxorubicin los tua cov qog thiab txo cov tshuaj tua kab mob toxicity | Zoptarelin doxorubicin yog cov hom phiaj peptide classic -tshuaj conjugate, tsim los ntawm conjugating LHRH agonist peptide nrog doxorubicin los ntawm kev sib txuas sib txuas. Nws lub hom phiaj cov neeg nqa khoom peptide khi nrog qhov tshwj xeeb siab rau LHRH receptors tau nthuav tawm ntawm qhov chaw ntawm cov qog hlwb, kho cov endocytosis ntawm cov conjugate rau hauv cov hlwb, thiab cov linker yog cleaved nyob rau hauv qhov kev txiav txim ntawm intracellular acidic ib puag ncig thiab enzymes, tso tawm active doxorubicin, uas intercalates rau hauv DNA thiab inhibits topoisis ntawm cov kab mob. cell apoptosis. Piv nrog dawb doxorubicin, nws ua rau kom cov tshuaj concentration ntawm cov qog nqaij hlav, txo cov tshuaj raug rau cov ntaub so ntswg xws li lub plawv thiab cov pob txha pob txha, thiab txo cov kev mob tshwm sim. Cov molecule no yog ib qho cuab yeej tseem ceeb rau peptide tshuaj conjugation thev naus laus zis tshawb fawb, kev tsim cov kab mob qog tsom rau kev kho mob, thiab kev kho tshuaj toxicity txo cov txheej txheem optimization. | Kev tshawb fawb txog kev mob qog noj ntshav prostate, kev tshawb fawb mob cancer mis, Peptide tshuaj conjugation technology, Targeted antitumor tshawb fawb, Tshuaj kho mob toxicity txo, Reproductive endocrine hlav | Gonadotropin-Tshuaj Hormone Receptor (GnRHR/LHRHR); Topoisomerase II inhibition; DNA puas thiab qog cell apoptosis txoj kev |
Cim npe nrov: CAS: 139570-93-7: Zoptarelin Doxorubicin, Tuam Tshoj CAS: 139570-93-7: Zoptarelin Doxorubicin manufacturers, lwm tus neeg, Hoobkas
