Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov muag khoom ntawm cas 876296-47-8 selepressin hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau kev lag luam wholesale bulk zoo cas 876296-47-8 selepressin los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 876296-47-8: Selepressin |
| Kev piav qhia | Selepressin yog ib tug tshiab tiam neeg xaiv vasopressin V1a receptor agonist. Multi-site amino acid hloov kho ua tau zoo txhim kho V1a receptor subtype selectivity. Nws tshwj xeeb ua rau vascular du leeg V1a receptors, constricts cov hlab ntsha thiab nce lub siab arterial siab, rau vasodilatory shock pressor kho. Nws muaj affinity tsawg heev rau V2 receptors, tsis muaj kev pom tseeb antidiuretic thiab dej-sodium retention phiv, thiab muaj zog cardiovascular selectivity. Siv nyob rau hauv kev tshawb fawb mechanism ntawm septic shock, vasodilatory hypotension, vasopressin receptor muaj nuj nqi thiab lwm yam teb, raws li zoo raws li tshiab pressor peptide tshuaj txoj kev loj hlob. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Theoretical molecular hnyav (Da) | ~ 1080 (peptide dawb) |
| Hom qauv | Disulfide-bridged hloov kho nonapeptide analog, V1a xaiv heev |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Hom Cyclization | Receptor Selectivity |
| Selepressin | Selepressin; FE 202158; Xaiv V1a agonist | Selective vasopressor, V1a receptor agonism, Septic shock, Vasodilatory hypotension, Tsis muaj tshuaj tiv thaiv kab mob, Vasopressin analog | Hloov kho vasopressin cyclic peptide qaum, qhov chaw- optimized rau V1a selectivity, disulfide cyclized | C₄₆H₆₅N₁₃O₁₂S₂ | 1072.22 | 1072.22 | Intramolecular disulfide choj | High V1a selectivity, qis V2 affinity |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv -Lub Sijhawm Cia Cov Cai | Kua Stability | Khoom hmoov ruaj khov |
| PEB-SEP001 | hmoov dawb | Khaws ntawm -20 degree, nruj me ntsis tiv thaiv los ntawm lub teeb, kaw & qhuav, aliquoted. ** txwv tsis pub muaj zog los txo cov neeg ua hauj lwm ** | ruaj khov rau 1 lub hlis ntawm 2-8℃kaw & qhuav; npaj cov tshuaj aqueous tshiab ua ntej siv | ruaj khov rau 72h ntawm 4 degree; ruaj khov rau 1 lub hlis ntawm -20℃hauv aliquots. ** Cov dej zoo solubility, dawb do soluble hauv dej thiab physiological tsis **. Disulfide choj rhiab heev rau cov muaj zog txo cov neeg ua haujlwm thiab nquag cleavage. Cov kev hloov kho ntawm qhov chaw tseem ceeb txhim kho enzymatic tsis kam | ruaj khov rau 3 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-SEP001 | Muaj kev xaiv V1a receptor agonist uas tshwj xeeb ua rau cov hlab ntsha thiab nce ntshav siab uas tsis muaj qhov pom tseeb los tiv thaiv kev mob tshwm sim. | Selepressin yog ib qho tshiab - tiam arginine vasopressin analog optimized los ntawm ntau - hloov chaw. Amino acid site optimization ho txhim kho kev xaiv rau V1a receptors thiab tsis tshua muaj affinity rau V2 receptors, yog li thaum exerting muaj zog vasoconstrictive pressor nyhuv, nws tsis muaj teeb meem V2-kev kho mob tshwm sim xws li dej-sodium retention thiab hyponatremia, nrog ho zoo dua cardiovascular selective 10} ntau dua li cov tsis muaj zog. Nws tshwj xeeb khi rau V1a receptors ntawm vascular du leeg hlwb, activates Gq / PLC-IP3 signaling pathway, elevates intracellular calcium concentration, induces vascular du nqaij contraction, tsub kom peripheral tsis kam thiab txhais tau tias arterial siab, thiab tswj lub cev tseem ceeb perfusion. Nws tuaj yeem kho cov ntshav siab zoo thiab txhim kho cov ntaub so ntswg perfusion hauv septic shock thiab vasodilatory hypotension qauv. | Kev tshawb fawb septic shock, Vasodilatory hypotension, Vasopressin receptor function, Cardiovascular pharmacology, Shock resuscitation, Pressor tshuaj txhim kho | Vasopressin V1a Receptor (V1aR); Gq/PLC-IP3-Ca²⁺ taw qhia txoj hauv kev; Vasoconstriction thiab ntshav siab tswj txoj hauv kev |
Cim npe nrov: CAS 876296-47-8 selepressin, Tuam Tshoj cas 876296-47-8 selepressin manufacturers, lwm tus, Hoobkas
