Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 949100-39-4 delcasertib hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 949100-39-4 delcasertib los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 949100-39-4: Delcasertib |
| Kev piav qhia | Delcasertib (tseem hu ua KAI-9803) yog ib qho kev xaiv me me-molecule inhibitor ntawm δ-protein kinase C. Nws tuaj yeem nkag mus rau hauv cov cell membrane rau hauv cytoplasm, sib tw khi rau ATP-binding domain ntawm δ-PKC, inhibit qhov phosphotransferase kev ua ntawm kinases kev raug mob, txo qis kev cuam tshuam thiab txo cov teeb liab. apoptosis ntawm cardiomyocytes induced los ntawm ischemia-reperfusion, txo myocardial infarct loj thiab txhim kho plawv kev ua haujlwm. Nws muaj kev xaiv siab rau δ-subtype kinase, nrog rau qhov tsis muaj zog ntawm lub hom phiaj ntawm lwm yam PKC subtypes thiab kinase tsev neeg. Siv nyob rau hauv kev tshawb fawb mechanism thiab kev tsim tshuaj rau myocardial ischemia, cerebral ischemia, organ ischemia-reperfusion raug mob thiab lwm yam. |
| Purity (HPLC, %) | 95%/98%/99% |
| Cov mis mos molecular | C₂₇H₃₁N₅O₃ |
| Molecular Luj (Da) | 473.57 |
| Hom qauv | Me-molecule isoquinoline kinase inhibitor, non-peptide |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Hloov kho hom | Yam khoom |
| Delcasertib | Delcasertib; KIAB-9803 | δ-PKC xaiv inhibition, Cardioprotection, Ischemia-reperfusion raug mob, Kinase inhibitor, me me- tshuaj molecule, tiv thaiv lub cev | Isoquinoline niam txiv nucleus nrog sab - saw hloov kho kinase-binding domain | C₂₇H₃₁N₅O₃ | 473.24 | 473.57 | Me me -molecule organic compound | Tsis yog -peptide kinase inhibitor |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| SML{0}}DEL001 | Dawb rau tawm -dawb crystalline hmoov | Khaws ntawm -20 degree, kaw, qhuav & tiv thaiv los ntawm lub teeb, nitrogen- tiv thaiv, aliquoted; zam rov qab khov-thaw cycles thiab oxidation | ruaj khov rau 1 lub hlis ntawm 2-8℃kaw & qhuav; ice pob shipping pom zoo | ruaj khov rau 7 hnub ntawm 4℃nyob rau hauv cov dej tsis muaj dej; Cov tshuaj aqueous nquag ua rau oxidative inactivation, npaj tshiab ua ntej siv, ** Cov dej tsis zoo solubility, yuav tsum muaj cov kuab tshuaj organic xws li DMSO thiab DMF rau kev sib cais, yooj yim rau precipitate hauv physiological tsis **. Me me -molecule kinase inhibitor ua rau oxidative degradation | ruaj khov rau 2 xyoos ntawm -20℃nyob rau hauv qhuav & tsis muaj oxygen |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| SML{0}}DEL001 | Muaj kev xaiv me me -molecule δ-PKC inhibitor uas thaiv cov cim kev raug mob ischemic thiab txo cov myocardial ischemia- rov ua dua raug mob | Delcasertib inhibits kinase autophosphorylation thiab substrate phosphorylation kev ua haujlwm los ntawm kev xaiv khi rau ATP-binding hnab tshos ntawm δ-protein kinase C, blocks pro-apoptotic signaling pathway mediated los ntawm δ{-PKC0} txo qis thaum lub sij hawm fusions. kev puas tsuaj, oxygen dawb radical tawg thiab apoptosis, li no alleviating ischemia-reperfusion raug mob ntawm lub cev xws li lub plawv, hlwb thiab lub raum, txo infarct loj thiab txhim kho lub cev ua haujlwm. Nws cov kev xaiv rau δ-subtype yog siab dua li lwm yam PKC subtypes, nrog qis dua - lub hom phiaj toxicity. Nws yog cov cuab yeej cuab tam classic rau kev kawm PKC subtype muaj nuj nqi thiab cov kab mob ischemic. | Kev tshawb fawb myocardial ischemia, Ischemia-kev raug mob rov ua dua, Kinase muaj nuj nqi siv tau, kev tiv thaiv lub cev, kab mob plawv thiab paj hlwb, me- kev txhim kho tshuaj molecule | δ-Protein Kinase C (δ-PKC); Ischemia-reperfusion apoptosis qhia txoj hauv kev; Kinase phosphorylation inhibitory txoj kev |
Cim npe nrov: CAS 949100-39-4 delcasertib, Tuam Tshoj cas 949100-39-4 delcasertib manufacturers, lwm tus, Hoobkas
