Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov muag khoom ntawm nn1177 (nnc9204-1177) hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo nn1177 (nnc9204-1177) los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | NWS 1177 (NNC9204-1177) |
| Kev piav qhia | NN1177 yog qhov ntev - ua haujlwm GLP-1/glucagon receptor co-agonist, hloov nrog Aib hloov, C-terminal amidation thiab side-chain C18 fatty acid rau kev txhim kho metabolic stability. Nws yog siv rau hauv kev tshawb fawb txog kev rog, NASH thiab kab mob metabolic. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Cov mis mos molecular | C₂₀₆H₃₂₃N₅₁O₆₆ (dawb peptide) |
| Molecular Luj (Da) | 4570.07 (dawb peptide) |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Tag Nrho Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | N-Terminal Hloov kho | C-Terminal Hloov kho | Qhov ntev (aa) |
| SIB 1177 | NPO 1177; NNC9204-1177; GLP-1 / GCGR dual agonist | GLP-1/glucagon dual receptor co-agonist, Long-acting metabolic peptide, Kev tshawb fawb kev rog, kev tshawb fawb NASH, Lipolysis nce qib, Glucose homeostasis tswj | Histidine- -aminoisobutyric acid-Glutamine-Glycine-Threonine-Phenylalanine-Threonine-Serine-Aspartic acid-Leucine-Serine-Lysine-Tyrosine-Leucine-Glutamic acid-Serine-Lysine-Arginine-Alanine-Arginine{18} acid-Phenylalanine-Valine-Glutamine-Tryptophan-Leucine-Leucine-Lysine(sab-chain conjugated Glu{28}} Glu-Ser-Glu-Ser- Glu- Glu-C18 diacid)-Threoninamide | C₂₀₆H₃₂₃N₅₁O₆₆ (dawb peptide) | 4569.23 | 4570.07 | Native dawb amine, nrog Aib unnatural amino acid hloov | Amidation | 29 (tub ntxhais peptide qaum nrog sab - hloov saw hlau) |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv luv -Lub Sijhawm Cia Cia | Kua Stability | Khoom hmoov ruaj khov |
| PEB-NN117701 | hmoov dawb | Khaws ntawm -20℃, nruj me ntsis tiv thaiv los ntawm lub teeb, kaw thiab qhuav, khaws cia hauv aliquots; zam rov qab khov-thaw mus thiab fibrillation | Khoom hmoov ruaj khov rau 2 xyoos ntawm 2-8℃kaw thiab qhuav; cov kev daws teeb meem tau pom zoo kom npaj rau hauv DMSO thiab khaws cia ntawm -80℃hauv aliquots | ruaj khov rau 72 h ntawm 4 degree; ruaj khov rau 6 lub hlis ntawm -80℃hauv aliquots; ruaj khov rau 1 lub hlis ntawm -20℃hauv aliquots. ** Cov dej tsis zoo solubility, me ntsis soluble hauv dej **, DMSO xav tau rau solubilization. Nyuaj mus rau aggregation thiab fibrillation thaum lub sij hawm cia; tsis txhob rov ua kom khov-thaw thiab muaj zog tuav | ruaj khov rau 3 xyoos ntawm -20℃nyob rau hauv qhuav thiab tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-NN117701 | Ntev- ua haujlwm GLP-1/glucagon dual receptor co-agonist nrog kev sib koom ua ke poob phaus thiab txhim kho metabolic, siv rau kev rog rog thiab NASH mechanism tshawb fawb | NN1177 yog ib tug ntev - ua yeeb yam dual agonist ntawm glucagon-zoo li peptide-1 receptor (GLP-1R) thiab glucagon receptor (GCGR). Nws cov pob txha caj qaum yog tsim los ntawm glucagon ib ntus, nrog Aib hloov pauv thiab C-terminal amidation txhawm rau txhim kho kev ruaj ntseg enzymatic, thiab qhov tsis zoo them nyiaj txuas-conjugated C18 fatty diacid ntawm lysine sab saw kom ntev hauv vivo ib nrab -lub neej ntawm albumin binding. Nws ib txhij ua rau ob txoj hauv kev hauv metabolic: GLP-1 txoj hauv kev kho cov piam thaj- nyob ntawm kev tso tawm insulin, kev noj qab haus huv thiab ncua kev ua pa hauv plab; txoj kev glucagon txhawb nqa lub siab lipolysis thiab kev siv hluav taws xob. Cov nyhuv synergistic ua tiav kev poob phaus zoo dua thiab txhim kho glucolipid metabolic. Cov kev tshawb fawb preclinical qhia pom qhov txo qis hauv lub cev qhov hnyav, txo cov rog, thiab ameliorated hepatic steatosis thiab fibrosis hauv cov nas rog rog. Nws ua haujlwm raws li cov cuab yeej tseem ceeb molecule rau kev tshawb fawb txog kev rog, NASH thiab hom 2 mob ntshav qab zib, nrog rau kev txhim kho tshuaj peptide ob lub hom phiaj. | Kev tshawb fawb txog kev rog rog, Tsis yog -kev tshawb fawb txog cawv steatohepatitis, Kev tshawb nrhiav ntshav qab zib hom 2, kev tshawb fawb Glucolipid metabolism, Dual- lub hom phiaj peptide tshuaj txhim kho, Kev tshawb fawb zog metabolism | Glucagon-Zoo li Peptide-1 Receptor (GLP-1R); Glucagon Receptor (GCGR); cAMP/PKA metabolic tswj txoj hauv kev; Hepatic lipolysis txoj kev |
Cim npe nrov: nn1177 (nnc9204-1177), Tuam Tshoj nn1177 (nnc9204-1177) manufacturers, lwm tus neeg, Hoobkas
