Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm sar441255 tfa hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau kev lag luam wholesale bulk zoo sar441255 tfa los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | SAR441255 TFA |
| Kev piav qhia | SAR441255 TFA yog ib qho muaj zog unimolecular peptide GLP-1/GIP/glucagon receptor triagonist. Nws ua rau tib neeg GLP-1R, GCGR thiab GIPR nrog lub zog siab thiab kev ua haujlwm sib luag, ua rau qis qis cAMP tsub zuj zuj, thiab ua kom muaj kev sib koom ua ke ntawm kev txo cov piam thaj, txo qhov hnyav thiab txo cov lipid. Hloov kho nrog unnatural amino acids thiab fatty acid sab chains, nws tau ho ncua ntev hauv vivo ib nrab-lub neej. Hauv cov qauv tsiaj, nws ua rau lub cev hnyav zuj zus ntxiv, txhim kho glycemic tswj thiab txo lub siab raug mob, thiab tau txais txiaj ntsig zoo hauv kev noj qab haus huv. Nws yog cov cuab yeej tseem ceeb peptide rau kev tshawb fawb txog cov kab mob metabolic xws li hom 2 mob ntshav qab zib, rog rog thiab NAFLD, nrog rau kev txhim kho tshuaj peptide. |
| Peptide Purity (HPLC, %) | 95% / 98% / 99% |
| Dawb peptide molecular mis | C₂₂₅H₃₅₅.₅N₅₇O₆₃ |
| Dawb peptide molecular hnyav (Da) | 4866.56, siab dua rau TFA ntsev daim ntawv |
| Hom qauv | Linear hloov peptide, nrog unnatural amino acids thiab palmitic acid sab saw hloov, trifluoroacetate ntsev |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| SAR441255 TFA | SAR441255 trifluoroacetate; GLP-1/GIP/GCGR triagonist | Balanced GLP-1/GIP/GCGR triple receptor agonist, txo cov piam thaj, poob phaus, tswj lipid, tswj kev ua haujlwm ntev ntawm metabolic | Ntev- ua yeeb yam hloov pauv peptide tau los ntawm Exendin-4 qaum, muaj 3 Aib thiab D-Ala unnatural amino acids, palmitic acid sab saw txuas rau Lys14 ntawm di- -glutamic acid, C-terminal amidation. Tseem ceeb txhim khu -helix stability thiab peptidase kuj. | Dawb puag: C₂₂₅H₃₅₅N₅₇O₆₃; Daim ntawv ntsev: C₂₂₅H₃₅₅N₅₇O₆₃·xC₂HF₃O₂ | 4863.60 (dawb puag) | 4866.56 (dawb puag) | Trifluoroacetate (TFA) | 39 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-SAR001 | Dawb rau tawm -dawb hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb, hauv qab cua nitrogen. Aliquot kom tsis txhob rov khov dua -thaw cycles. -80℃pom zoo rau kev cia mus ntev. | ruaj khov rau 2 xyoos ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau luv luv -lub sij hawm shipping ntawm ambient kub, haum rau chav tsev kub logistics. | Ruaj khov rau 7 hnub ntawm 4℃hauv kev daws teeb meem. Solubility: ~ 100 mg / mL hauv DMSO (yuav tsum tau sonication); me ntsis soluble hauv dej ntshiab (0.1-1 mg / mL). Npaj aqueous ua hauj lwm tov los ntawm serial dilution los ntawm DMSO Tshuag. Aliquot sterilely tom qab reconstitution. ruaj khov rau 6 lub hlis ntawm -80℃thiab 1 lub hlis ntawm -20℃hauv kev daws. Rov qab khov-thaw ua rau peptide aggregation thiab degradation. | ruaj khov rau 3 xyoos ntawm -20℃thiab 2 xyoos ntawm 4 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-SAR001 | Balanced GLP-1/GIP/GCGR triagonist nrog ntev- ua kua qabzib- txo qis, qhov hnyav- poob thiab tswj cov lipids | SAR441255 TFA yog lub zog tsis muaj zog peptide triagonist ntawm GLP-1, GIP thiab glucagon receptors. Nws ua rau tib neeg GLP-1R, GCGR thiab GIPR nrog lub zog siab thiab kev ua haujlwm sib luag, ua rau qis qis cAMP sib xyaw, thiab ua kom muaj txiaj ntsig zoo hauv metabolic nrog rau kev txo qis qabzib, poob phaus thiab tswj lipid. Hloov kho nrog unnatural amino acids thiab palmitic acid sab saw, nws tau txhim kho -helix stability, txhim kho peptidase kuj thiab ntev nyob rau hauv vivo ib nrab -lub neej. Nws induces koob tshuaj-raws li lub cev qhov hnyav txo, txhim kho glycemic tswj thiab txo cov hepatic steatosis nyob rau hauv cov ntshav qab zib rog uas tsis yog-tib neeg primate qauv, thiab yog zoo tolerated nyob rau hauv noj qab haus huv kev kawm. Nws ua haujlwm raws li cov cuab yeej tseem ceeb peptide rau kev tshawb nrhiav kab mob metabolic thiab kev txhim kho tshuaj peptide. | Kev tshawb nrhiav ntshav qab zib hom 2, kev tshawb fawb txog kev rog rog, kev tshawb fawb NAFLD / NASH, kev tshawb fawb metabolic syndrome, kev txhim kho tshuaj peptide | Glucagon-zoo li peptide 1 receptor (GLP-1R); Glucose-dependent insulinotropic polypeptide receptor (GIPR); Glucagon receptor (GCGR); cAMP signaling txoj kev |
Cim npe nrov: sar441255 tfa, Tuam Tshoj sar441255 tfa manufacturers, lwm tus, Hoobkas
