Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov tuam txhab ua lag luam thiab cov chaw muag khoom ntawm cas 157675-61-1 eak16-ii (self-assembling peptide) hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 157675-61-1 eak16-ii (self-assembling peptide) los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Kev piav qhia | EAK16-II (CAS: 157675-61-1) is a 16-amino acid self-assembling peptide with the sequence Ac-Ala-Glu-Ala-Glu-Ala-Lys-Ala-Lys-Ala-Glu-Ala-Glu-Ala-Lys-Ala-Lys-NH₂ (Ac-AEAEAKAKAEAEAKAK-NH₂), N-terminally acetylated and C-terminally amidated. EAK16-II is one of the earliest discovered self-assembling peptides, discovered and named by Shuguang Zhang's laboratory in the 1990s from a repeat sequence of the yeast protein zuotin; its name derives from its amino acid composition (E = glutamic acid, A = alanine, K = lysine) and peptide length (16 amino acids), with "II" indicating it as the second member of the EAK16 family. The sequence design of EAK16-II features typical ionic complementary characteristics: negatively charged glutamic acid (Glu, E) and positively charged lysine (Lys, K) are alternately arranged, interspersed with hydrophobic alanine (Ala, A), forming the AEAEAKAK repeat pattern. This alternating arrangement of charged and hydrophobic residues enables EAK16-II to self-assemble into stable β-sheet secondary structures in aqueous solution, and further assemble into nanofibers and hydrogels. Self-assembly mechanism of EAK16-II: (1) in deionized water, EAK16-II dissolves in a random coil form; (2) when exposed to physiological ionic strength (>20 mM NaCl, ib txwm ntsev concentration hauv tib neeg lub cev kua yog 154 mM), ions tiv thaiv electrostatic repulsion ntawm glutamic acid thiab lysine, ua rau muaj kev hloov pauv ntawm cov saw peptide los ntawm random coil mus rau - ntawv; (3) -cov ntawv peptide chains tus kheej- sib sau ua ke rau hauv nanofibers nrog txoj kab uas hla ntawm kwv yees li 10-20 nm los ntawm kev sib txuas ntawm cov tshuaj hydrogen thiab kev sib cuam tshuam hydrophobic; (4) nanofibers ntxiv interweave los tsim ib qho peb- qhov sib txuas network qauv, encapsulating ntau cov dej molecules los ua hydrogel. Cov yam ntxwv tseem ceeb thiab kev siv ntawm EAK16-II: (1) cov ntaub so ntswg engineering scaffolds - EAK16-II hydrogels muaj biocompatibility zoo thiab biodegradability, tuaj yeem ua 3D cell kab lis kev cai scaffolds txhawb kev loj hlob, sib txawv, thiab cov ntaub so ntswg rov tsim dua tshiab ntawm ntau lub hlwb (xws li cov neurons, hepatocytes, thiab lwm yam); (2) Cov neeg nqa tshuaj xa tshuaj - hydrogels tuaj yeem ntim cov tshuaj molecule me me, peptides, proteins, thiab nucleic acids rau kev tso tawm; (3) kho qhov txhab thiab kho cov ntaub so ntswg - hydrogels tuaj yeem ua cov ntaub qhwv lub qhov txhab los txhawb cov ntaub so ntswg kho; (4) 3D kab lis kev cai ntawm tes thiab kab lis kev cai organoid - muab cov hlwb nrog 3D microenvironment ua raws li hauv vivo extracellular matrix; (5) biomaterial nto hloov kho - txhim kho cell adhesion thiab biocompatibility ntawm biomaterial nto. Lub zog txhua yam thiab gelation tus nqi ntawm EAK16-II hydrogels tuaj yeem hloov kho los ntawm peptide concentration, ionic zog, thiab pH. N-terminal acetylation thiab C-terminal amidation tshem tawm cov nqi davhlau ya nyob twg, txhim kho tus kheej kev ua haujlwm thiab kev ruaj ntseg ntawm peptide. |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| UA 16-II | EAK16-II tus kheej- sib dhos peptide; ionic complementary - daim ntawv peptide | Tus kheej- sib dhos hydrogel, cov ntaub so ntswg engineering scaffold, 3D cell kab lis kev cai, biomaterial | Classic ionic complementary 16-mer tsim los ntawm rov ua Ala-Glu-Ala-Lys sequences; tus kheej- sib sau ua ke rau hauv -sheet nanofiber hydrogel ntawm electrostatic complementarity thiab hydrogen bonding ntawm physiological ntsev concentration | C₆₄H₁₁₃N₂₁O₂₅ | 1556.82 | ~1557.9 | Acetate | 16 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-EAK16 | Dawb hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot rau cia. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau shipping ntawm ambient kub. | ruaj khov rau 7 hnub ntawm 4 degree. Soluble nyob rau hauv dilute acetic acid thiab deionized dej. Ionic complementary tus kheej- sib dhos peptide; soluble thiab ruaj khov nyob rau hauv qis - ntsev acidic tej yam kev mob. Tus kheej sai sai- sib sau ua ke rau hauv -cov ntawv hydrogel ntawm physiological ntsev concentration thiab nruab nrab pH. Tsis txhob npaj thiab cia rau hauv siab -cov tshuaj ntsev. | ruaj khov rau 2 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-EAK16 | EAK16-II ionic complementary tus kheej- sib dhos peptide forms -sheet hydrogel scaffold | EAK16-II yog ib qho classic ionic complementary tus kheej- sib dhos peptide tsim los ntawm alternating negatively charged glutamic acid, zoo them lysine thiab hydrophobic alanine. Nws dissolves nyob rau hauv qis - ntsev tej yam kev mob, thiab spontaneously sib sau ua ke rau hauv -sheet nanofibers thiab ces 3D ntxeem tau hydrogel scaffolds ntawm physiological ntsev concentration ntawm electrostatic complementarity, hydrogen bonding thiab hydrophobic kev sib tshuam, txhawb cell adhesion thiab kev loj hlob. | Tissue engineering & regenerative tshuaj, 3D kab lis kev cai ntawm tes, biomaterial hydrogels, tswj cov tshuaj tso tawm cov cab, supramolecular tus kheej- sib dhos | Ionic complementary electrostatic kev sib cuam tshuam; -daim ntawv thib ob qauv; nanofiber tus kheej -sembly txoj kev |
Cim npe nrov: cas 157675-61-1 eak16-ii (self-assembling peptide), Tuam Tshoj cas 157675-61-1 eak16-ii (self-assembling peptide) manufacturers, lwm tus neeg, Hoobkas
