Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 622402-94-2 (kff) 3k hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau kev lag luam wholesale bulk zoo cas 622402-94-2 (kff) 3k los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Kev piav qhia | (KFF)3K (CAS: 622402-94-2) yog 10-amino acid cationic amphipathic cell-peptide uas muaj peb lub KFF (lysine-phenylalanine-}phenylalanine ib zaug), 1 mins rov ua dua thiab kab ke KFFKFFKFFK thiab C-terminal amidation. Nws cov qauv muaj 4 lysine residues (tus nqi them +4) thiab 6 phenylalanine residues (muaj zog hydrophobic), muaj peev xwm tsim tau ib qho amphipathic conformation nyob rau hauv membrane ib puag ncig. (KFF) 3K yog cov kab mob classic penetrating peptide uas cuam tshuam rau sab nrauv ntawm Gram - cov kab mob tsis zoo (los ntawm kev sib cuam tshuam electrostatic nrog lipopolysaccharide LPS thiab hydrophobic insertion), yog li pab txhawb kev nkag ntawm lwm cov tshuaj tua kab mob thiab peptide nucleic acid (PNA) oligomers rau hauv cov kab mob. Cov kev tshawb fawb tau pom tias (KFF) 3K tuaj yeem xa PNAs rau hauv ob qho tib si Gram-negative thiab Gram-positive kab mob, ua tiav cov kab ke tshwj xeeb ntawm cov gene silencing. Tsis tas li ntawd, (KFF) 3K nws tus kheej nthuav tawm cov tshuaj tua kab mob, tua cov kab mob los ntawm daim nyias nyias permeabilization. Taw qhia (KFF) 3K rau hauv hydrocarbon scaffolds (stapled peptide lub tswv yim) tuaj yeem txhim kho nws cov kev ua haujlwm antimicrobial thiab protease stability, ua rau nws yog ib qho tseem ceeb ntawm peptide rau kev txhim kho cov tshuaj tua kab mob tshiab thiab cov kab mob xa mus. |
Product Basic Information Table
| Lub npe txheem | Cov npe | CAS Nr. | Core Function Tags | Hom qauv | Molecular Formula | Exact Mass (Da) | Daim ntawv ntsev | Sib Nqus Ntev |
| (KFF) 3K | Trimeric KFF peptide; tri-Lys-Phe-Phe antimicrobial peptide | 622402-94-2 | Dav -spectrum antimicrobial, membrane cuam tshuam, microbiota kev cai, kev kho mob | Cationic amphiphilic linear antimicrobial peptide | C₆₆H₉₅N₁₃O₇ | 1201.74 | Acetate | 10 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-KFF003 | Dawb hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot rau cia. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau shipping ntawm ambient kub. | ruaj khov rau 7 hnub ntawm 4 degree. Soluble nyob rau hauv dilute acetic acid, acidic buffers thiab dej. Amphiphilic antimicrobial peptide ua rau nws tus kheej - sib dhos ntawm nruab nrab pH; zoo solubility thiab kev ua si nyob rau hauv acidic tej yam kev mob. | ruaj khov rau 2 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-KFF003 | (KFF) 3K trimeric antimicrobial peptide exerts broad -spectrum kev ua los ntawm kev cuam tshuam membrane | (KFF) 3K yog ib qho cationic amphiphilic antimicrobial peptide uas muaj peb qhov rov ua dua Lys-Phe-Phe units ntxiv rau lub davhlau ya nyob twg lysine. Kev them nyiaj zoo lysine tsom cov kab mob tsis zoo ntawm cov kab mob electrostatic cuam tshuam, thiab hydrophobic phenylalanine inserts thiab cuam tshuam cov qauv ntawm daim nyias nyias, ua rau cytoplasmic leakage thiab kev loj hlob sai inhibition ntawm Gram-zoo thiab Gram-cov kab mob tsis zoo. Nws kuj modulates inflammatory teb thiab txhawb lub qhov txhab kho, muaj feem xyuam rau cov khoom siv tshuaj tua kab mob, kev tu tawv nqaij thiab kev tshawb fawb kho qhov txhab. | Antimicrobial peptide kev tshawb fawb, daim tawv nqaij microbiota hloov kho, kho qhov txhab, kev tshawb fawb txog kev mob, cov ntaub ntawv biomedical | Cov kab mob membrane permeability; electrostatic targeting membrane cuam tshuam; innate tiv thaiv kab mob |
Cim npe nrov: CAS 622402-94-2 (kff) 3k, Tuam Tshoj cas 622402-94-2 (kff) 3k manufacturers, lwm tus, Hoobkas
