Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov chaw muag khoom ntawm cyclic nona-l-arginine tfa hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cyclic nona-l-arginine tfa los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Kev piav qhia | Cyclic nona-L-arginine TFA yog ib tug cyclic cell- nkag peptide tsim los ntawm lub taub hau- mus rau -tail peptide bond cyclization ntawm 9 L-arginine residues, muab raws li ib tug trifluoroacetic acid (TFA) ntsev. Linear nona-arginine (R9) yog ib qho ntawm tes classic- nkag mus rau peptide, tab sis nws cov qauv linear raug cuam tshuam rau proteolytic degradation thiab muaj kev txwv ntawm cellular uptake efficiency. Cyclization yog ib lub tswv yim zoo los txhim kho peptide stability thiab conformation: cyclic nona -arginine muaj ib tug ntau compact spatial conformation, tso cai rau cov guanidinium pawg ntawm arginine sab chains kom ntau uniformly faib nyob rau hauv qhov chaw, pab txhawb multivalent kev koom tes khi rau anionic membrane Cheebtsam; ib txhij, cov qauv cyclic tshem tawm dawb N- thiab C-termini, ua kom muaj zog tiv thaiv aminopeptidases thiab carboxypeptidases thiab txuas ntxiv hauv vivo ib nrab- lub neej. Cov kev tshawb fawb tau pom tias cyclic nona-arginine nthuav tawm cov cellular translocation sai dua thiab ntau dua intracellular tsub zuj zuj ntau dua li nws cov linear counterpart, zoo xa cov proteins, nucleic acids, nanoparticles, thiab cov tshuaj molecule me me rau hauv hlwb. Cyclic nona-arginine muaj kev siv dav hauv kev tshawb fawb neuroscience (neuroprotection), gene therapy, kev xa tshuaj, thiab kev tshuaj xyuas ntawm tes. |
Product Basic Information Table
| Lub npe txheem | Cov npe | CAS Nr. | Core Function Tags | Hom qauv | Molecular Formula | Exact Mass (Da) | Daim ntawv ntsev | Sib Nqus Ntev |
| Cyclic nona-L-arginine TFA | Cyclic nona-arginine TFA; R9 CPP | - | Kev nkag mus ntawm tes, enzyme- tiv taus ntev ncig, nucleic acid xa | Lub taub hau - mus rau -tail cyclized cationic cyclic peptide | C₅₄H₁₀₈N₃₆O₉ | 1428.87 (dawb peptide) | Trifluoroacetate (TFA) | 9 (cyclic nonapeptide) |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-CNR009 | Dawb hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot rau cia. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau shipping ntawm ambient kub. | ruaj khov rau 7 hnub ntawm 4 degree. TFA ntsev yog dawb do soluble nyob rau hauv dej, dilute acetic acid thiab acidic buffers. Cyclic qauv ho txhim kho protease kuj nrog kev ruaj ntseg zoo dua li pH ntau dua li linear peptides. | ruaj khov rau 2 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-CNR009 | Cyclic nona-arginine TFA nrog cyclization- txhim khu kev ruaj ntseg rau kev xa xov ntawm tes | Cyclic nona-arginine yog cyclic cationic cell- nkag mus rau peptide tsim los ntawm lub taub hau- mus rau -tail cyclization ntawm cuaj arginines. Piv nrog cov linear nona-arginine, lub cyclic conformation ho txhim kho protease kuj thiab serum stability, prolonging nyob rau hauv vivo ncig lub sij hawm. Lub zog zoo them nqi zoo khi thiab nkag mus rau hauv cell membranes, condenses thiab xa plasmid DNA thiab siRNA rau hauv cov hlwb uas muaj kev hloov pauv tau zoo thiab tsis tshua muaj cytotoxicity, haum rau kev kho noob thiab hauv vivo kev tshawb fawb. | Gene transfection & gene therapy, hauv vivo kev xa tshuaj, CPP thev naus laus zis, enzyme- tiv taus hloov pauv peptide, kev txhim kho tshuaj nucleic acid | Phospholipid bilayer; cyclization-ua kom muaj zog tiv thaiv kab mob; nucleic acid condensation & transmembrane xa |
Cim npe nrov: cyclic nona-l-arginine tfa, Tuam Tshoj cyclic nona-l-arginine tfa manufacturers, lwm tus neeg, Hoobkas
