Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov muag khoom ntawm vpm peptide tfa hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau kev lag luam wholesale bulk zoo vpm peptide tfa los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Kev piav qhia | VPM peptide TFA yog 16-amino acid dithiol protease-cleavable peptide crosslinker nrog cov kab ke GCRDVPMSMRGGDRCG, muab raws li trifluoroacetic acid (TFA) ntsev. Cov peptide muaj ob lub cysteine residues (Cys2 thiab Cys15) uas nws pawg thiol tuaj yeem siv los tsim cov ntawv cog lus disulfide lossis raug thiol conjugation nrog rau lwm cov molecules, yog li tsim cov cleavable crosslinked lug. Cov qauv tsim ntawm VPM peptide suav nrog cov txheej txheem substrate (VPMSMRGG, muab los ntawm gelatinase substrates) pom tau thiab cleavable los ntawm matrix metalloproteinases (MMPs, tshwj xeeb tshaj yog MMP-2 thiab MMP-9). Hauv cov qog nqaij hlav microenvironment, MMP-2/9 feem ntau qhia tau zoo heev, thiab VPM peptide crosslinks tuaj yeem raug tshem tawm tshwj xeeb los ntawm cov proteases, ua rau cov qog-tshuaj tswj cov tshuaj tso tawm. VPM peptide yog dav siv los tsim cov tshuaj stimuli-responsive xa cov tshuab, suav nrog polymeric micelles, liposomes, nanogels, thiab DNA nanostructures. Cov tshuab xa khoom sib txuas nrog VPM peptide tseem nyob ruaj khov hauv cov ntshav ncig, thiab thaum mus txog qhov chaw qog nqaij hlav yog cleaved los ntawm MMPs, tso cov tshuaj encapsulated chemotherapeutic lossis nucleic acid, yog li txhim kho kev kho mob thiab txo cov kab mob toxicity. |
Product Basic Information Table
| Lub npe txheem | Cov npe | CAS Nr. | Core Function Tags | Hom qauv | Molecular Formula | Exact Mass (Da) | Daim ntawv ntsev | Sib Nqus Ntev |
| VPM peptide TFA | VPM peptide; Cov kab mob nkag mus rau kev txhim kho peptide | - | Cell nkag mus li, membrane fusion pab, intracellular tso tawm | Viral - muab tau los ntawm hydrophobic fusion luv peptide | C₂₆H₃₉N₇O₇ | 561.29 (dawb peptide) | Trifluoroacetate (TFA) | 7 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-VPM001 | Dawb hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot rau cia. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau shipping ntawm ambient kub. | ruaj khov rau 7 hnub ntawm 4 degree. TFA ntsev yog soluble hauv dilute acetic acid, DMSO thiab acidic buffers. Hydrophobic peptide yog qhov kub thiab txias; nws yooj yim rau conformational hloov thiab membrane kev ua poob ntawm qhov kub thiab txias. | ruaj khov rau 2 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov Cheeb Tsam Tshawb Fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-VPM001 | VPM viral fusion peptide txhim kho cellular uptake thiab intracellular tso tawm | VPM peptide yog qhov ua haujlwm luv luv peptide tau los ntawm cov kab mob sib xyaw ua ke protein, nplua nuj nyob hauv proline thiab hydrophobic residues. Nws ua cov txheej txheem ntawm cov kab mob sib xyaw ua ke, pab cov cell thiab endosomal membrane fusion, thiab txhim kho cellular uptake thiab intracellular tso efficiency ntawm cov kab mob vectors, liposomes thiab nanomedicines. Nws kuj tseem siv tau rau hauv kev tshawb fawb membrane fusion mechanism, kab mob vector engineering thiab kev xa khoom kom zoo. | Viral vector engineering, membrane fusion mechanism kev tshawb fawb, tshuaj xa tshuab, cell nkag mus, nanomedicine | Cell / endosomal membrane fusion; kab mob fusion mimicry; intracellular tso tawm txhim kho |
Cim npe nrov: vpm peptide tfa, Tuam Tshoj vpm peptide tfa manufacturers, lwm tus neeg, Hoobkas
