Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov chaw muag khoom ntawm cyclic psap peptide hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cyclic psap peptide los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Kev piav qhia | Cyclic PSAP peptide yog 5-amino-acid side-chain-cyclized peptide nrog cov kab ke Cyclo(Asp-Trp-Leu-}Pro-Lys) (Cyclo(DWLPK) nyob rau sab twg), acid (Asp) tsim ib qho amide daim ntawv cog lus nrog rau sab -chain amino pawg ntawm lysine (Lys), tswj cov peptide nyob rau hauv ib tug cyclic conformation. PSAP (Prostate-Specific Acid Phosphatase) yog ib qho enzyme uas tau nthuav tawm hauv cov ntaub so ntswg prostate, ua lub luag haujlwm hauv kev txhim kho thiab kev loj hlob ntawm prostate cancer. Cyclic PSAP peptide (DWLPK) yog cyclic peptide nrog tus neeg sawv cev kho{16}}zoo li cov khoom; Cov kev tshawb fawb tau pom tias nws muaj peev xwm inhibit qog metastasis thiab txo cov qog loj hlob hauv vivo. Kev ua raws li cyclic yog qhov tseem ceeb rau kev lom zem ntawm cov peptide no: (1) txhim kho metabolic stability - cyclic conformation txwv txoj kev ywj pheej conformational ntawm peptide saw, txo qhov muaj feem ntawm kev lees paub thiab degradation los ntawm proteases, thiab txhim kho hauv vivo stability; (2) txhim kho receptor binding affinity - lub cyclic conformation kho cov peptide saw nyob rau hauv lub zoo conformation rau receptor binding, txo conformational entropy poob thaum binding, yog li nce binding affinity; (3) txhim kho bioavailability - cyclic peptides feem ntau muaj cov membrane permeability zoo dua thiab qhov ncauj bioavailability dua li linear peptides. Cov qauv tsim ntawm Cyclic PSAP peptide nthuav tawm cov yam ntxwv ntawm amphipathic: tryptophan (Trp) thiab leucine (Leu) muab hydrophobicity, aspartic acid (Asp) thiab lysine (Lys) muab nqi, thiab proline (Pro) qhia txog kev hloov pauv. Cov qauv amphipathic no tuaj yeem ua rau cov peptide cuam tshuam nrog cov cell membranes lossis cov receptors tshwj xeeb. Cov yam ntxwv tseem ceeb thiab kev siv ntawm Cyclic PSAP peptide: (1) qog nqaij hlav metastasis inhibition - cov kev tshawb fawb tau pom tias peptide no muaj kev ua haujlwm hauv inhibiting qog cell invasion thiab metastasis; (2) nyob rau hauv vivo qog kev loj hlob suppression - qhia tau hais tias muaj peev xwm mus suppress qog loj hlob nyob rau hauv cov tsiaj qauv; (3) tus neeg saib xyuas kho mob-zoo li cov khoom - muaj cov tshuaj-zoo li cov tshuaj pharmacokinetic thiab tuaj yeem ua cov khoom siv lead ua rau kev txhim kho tus neeg sawv cev kho mob; (4) protein-protein interaction inhibitor - tuaj yeem ua rau muaj kev cuam tshuam los ntawm kev cuam tshuam nrog cov protein tshwj xeeb-protein kev cuam tshuam; (5) tus kheej- sib dhos peptide - amphipathic cyclic peptides tuaj yeem muaj tus kheej- sib sau ua ke thiab tuaj yeem siv rau hauv kev tsim cov khoom siv nanomaterials thiab tshuaj xa khoom; (6) Cov cuab yeej tshawb fawb mob qog noj ntshav prostate - ua ib qho cuab yeej peptide los kawm txog lub luag haujlwm ntawm PSAP hauv kev mob qog noj ntshav prostate. Sab-chain cyclization (Asp-Lys amide daim ntawv cog lus) txawv ntawm lub taub hau- mus rau -tail cyclization, khaws cov N- thiab C-termini thaum tuav lub cyclic conformation los ntawm sab-chain linkage. |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| Cyclic PSAP peptide | Cyclic PSAP peptide; PSAP{0}} tsom rau cyclic peptide | Prostate cancer targeting, PSAP targeting, qog imaging, tsom xa tshuaj | Lub taub hau-rau-tail cyclized PSAP- tshwj xeeb heptapeptide ntawm amide daim ntawv cog lus; cyclization tseem ceeb txhim kho kev sib raug zoo ntawm kev sib raug zoo thiab tshwj xeeb rau prostatic acid phosphatase (PSAP), kev kho kom haum xeeb kev paub thiab kev siv tshuaj ntxiv hauv cov qog nqaij hlav qog nqaij hlav prostate. | C₂₈H₄₁N₉O₈ | 631.31 | ~631.7 | Acetate | 7 (cyclic heptapeptide) |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEB-CPSAP | Dawb hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot rau cia. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau shipping ntawm ambient kub. | ruaj khov rau 7 hnub ntawm 4 degree. Soluble hauv dej, dilute acetic acid thiab PBS. Cyclic qauv ho txhim kho protease kuj thiab broad pH stability; cyclic peptide daim ntawv cog lus ua rau hydrolysis nyob rau hauv huab cua muaj zog acid / puag. | ruaj khov rau 2 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-CPSAP | Cyclic PSAP-targeting peptide khi prostatic acid phosphatase nrog siab affinity | Cyclic PSAP peptide yog lub hom phiaj tshwj xeeb ligand rau prostatic acid phosphatase (PSAP). Lub taub hau -mus rau-tail amide cyclization txwv cov peptide rau hauv kev pom kev sib raug zoo, nrog rau PSAP kev sib txuas ntau dua thiab qhov tshwj xeeb tshaj li cov kab peptides. Nws kho cov phiaj xwm ua kom muaj txiaj ntsig zoo ntawm cov kws kho mob, cov tshuaj fluorescent imaging agents thiab nanocarriers hauv PSAP- overexpressing prostate cancer hlwb. | Prostate cancer tsom txoj kev kho, qog molecular imaging, tsom kev tsim tshuaj, kev tshawb fawb biomarker, nanocarrier targeting modification | Prostatic acid phosphatase (PSAP); receptor-mediated endocytosis; qog- phiaj xwm ntxiv |
Cim npe nrov: Tuam Tshoj cyclic psap peptide manufacturers, lwm tus neeg, Hoobkas
