Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov muag khoom ntawm mps -g i3 (membrane-permeable sequence - g protein alpha i3 subunit fusion peptide) hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo mps-g i3 (membrane-permeable sequence - g protein alpha i3 subunit fusion peptide) los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Kev piav qhia | MPS-G i3 yog 29-amino acid chimeric peptide tsim los ntawm Membrane-Permeable Sequence (MPS) fused nrog ib ntu peptide tau los ntawm G protein alpha inhibitory subunit 3 (G i3), nrog rau qhov sib lawv liag ntawm AAVALLPAV Cov peptide muaj ob txoj haujlwm ua haujlwm: (1) N-terminal MPS ib ntus (AAVALLPAVLLALLAK, 17 aa), lub cell hydrophobic heev -peptide nkag tau los ntawm daim nyias nyias -permeable sequence design of Kaposi's{1}assiated virus sarcomed Feem ntau ntawm hydrophobic residues xws li alanine, leucine, thiab valine, tsuas yog ib qho lysine residue ntawm C-terminus, muaj peev xwm nkag mus rau cov cell membranes tau zoo los ntawm kev sib cuam tshuam hydrophobic nrog cov cell membrane lipid bilayer thiab kev sib haum xeeb intracellular xa khoom; (2) C-terminal G i3- muab tau los ntawm peptide ntu (KNNLKECGLY, 12 aa), muab los ntawm ib cheeb tsam ua haujlwm tshwj xeeb ntawm G i3 subunit, uas yog inhibitory alpha subunit ntawm heterotrimeric G proteins, ua si lub luag haujlwm tseem ceeb hauv Gcoup (GP 2) receptors teeb liab (2) koom nrog inhibiting adenylate cyclase, tswj ion channel kev ua haujlwm, thiab tswj cov cell proliferation, sib txawv, thiab lwm yam txheej txheem. MPS-G i3 fusion peptide siv lub xov tooj ntawm tes- nkag mus rau hauv lub peev xwm ntawm MPS kom xa cov G i3 ua haujlwm peptide ntu rau hauv cov hlwb rau kev kawm txog lub luag haujlwm ntawm G i3 hauv GPCR teeb liab hloov, G protein subunit muaj nuj nqi, cellular signaling pathway regulation, thiab mechanisms of G protein-related disease. Cov peptide no tuaj yeem ua cov cuab yeej hloov pauv protein rau kev tshawb fawb txog kev hloov pauv hauv lub cev thiab muaj peev xwm kho tau. C-terminal cysteine residue tuaj yeem siv rau kev ua haujlwm ntxiv lossis kev sib txuas. |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Daim ntawv ntsev | Ntev (aa) |
| MPS-G i3 | Membrane-permeable sequence G i3 fusion peptide; G protein signaling inhibitor peptide | Cell nkag mus, G protein signaling inhibition, GPCR txoj kev tshawb fawb, membrane protein cuam tshuam | Fusion ntawm membrane-permeable sequence (MPS) thiab G protein i3 (G i3) ua haujlwm peptide; MPS kho kom zoo ntawm cov cell nkag mus, thiab G i3 peptide tshwj xeeb thaiv GDP / GTP pauv ntawm G i | C₁₁₀H₁₈₆N₃₄O₂₆ | 2480.4 | ~2482.1 | Acetate | 21 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia | Luv - Lub Sij Hawm Cia | Kev daws teeb meem | Khoom hmoov ruaj khov |
| PEP-MPS-GI | Dawb hmoov | Khaws ntawm -20 degree, kaw, qhuav thiab tiv thaiv los ntawm lub teeb. Aliquot rau cia. | ruaj khov rau 1 lub hlis ntawm 2-8℃nyob rau hauv kaw qhuav; ruaj khov rau shipping ntawm ambient kub. | ruaj khov rau 7 hnub ntawm 4 degree. Soluble nyob rau hauv dilute acetic acid, acidic buffers thiab DMSO. Zoo stability ntawm amphiphilic fusion peptide nyob rau hauv acidic tej yam kev mob; Nws yooj yim rau hydrophobic aggregation ntawm nruab nrab pH. | ruaj khov rau 2 xyoos ntawm -20 degree, qhuav thiab tiv thaiv los ntawm lub teeb. |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov Cheeb Tsam Tshawb Fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEP-MPS-GI | MPS-G i3 fusion peptide sib txuas cov cell nkag mus & G protein signaling inhibition | MPS-G i3 yog ib qho kev ua haujlwm fusion peptide. MPS cov txheej txheem kho kom haum xeeb kom muaj txiaj ntsig zoo ntawm cov cell membrane nkag mus, thiab G i3 ua haujlwm peptide tshwj xeeb khi rau GDP-binding hnab tshos ntawm G i protein, thaiv GDP-GTP pauv thiab inhibiting downstream G i signaling. Nws yog siv rau GPCR signaling pathway research, G protein functional validation and membrane protein interaction studies. | GPCR signaling research, G protein function study, cell- nkag mus rau tus me nyuam, membrane protein sib cuam tshuam, signaling pathway inhibitors | G i protein GDP-binding site; GPCR downstream signaling txoj kev; MPS-kev hloov pauv hloov pauv hloov pauv |
Cim npe nrov: mps-g i3 (membrane-permeable sequence - g protein alpha i3 subunit fusion peptide), Tuam Tshoj mps-g i3 (membrane-permeable sequence -} g protein alpha i3 subunit fusion peptide), manufacturers,
